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Drugs reference index «Anzemet»

Anzemet

Generic Name: dolasetron (Oral route, Intravenous route)

doe-LAS-e-tron

Commonly used brand name(s):

In the U.S.

  • Anzemet

Available Dosage Forms:

  • Solution
  • Tablet

Therapeutic Class: Antiemetic

Pharmacologic Class: Serotonin Receptor Antagonist, 5-HT3

Uses For Anzemet

Dolasetron is used to prevent and treat the nausea and vomiting that may occur after treatment with anticancer medicines (chemotherapy) or after surgery.

This medicine is available only with your doctor's prescription.

Before Using Anzemet

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

This medicine has been tested in a limited number of children between 2 and 17 years of age with cancer. In effective doses, this medicine has not been shown to cause different side effects or problems than it does in adults.

Geriatric

This medicine has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Apomorphine
  • Bepridil
  • Cisapride
  • Levomethadyl
  • Mesoridazine
  • Pimozide
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Ajmaline
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amoxapine
  • Aprindine
  • Arsenic Trioxide
  • Astemizole
  • Azimilide
  • Bretylium
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Clarithromycin
  • Desipramine
  • Dibenzepin
  • Disopyramide
  • Dofetilide
  • Doxepin
  • Droperidol
  • Enflurane
  • Erythromycin
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Foscarnet
  • Gemifloxacin
  • Halofantrine
  • Haloperidol
  • Halothane
  • Hydroquinidine
  • Ibutilide
  • Imipramine
  • Isoflurane
  • Isradipine
  • Lidoflazine
  • Lorcainide
  • Mefloquine
  • Nortriptyline
  • Octreotide
  • Pentamidine
  • Pirmenol
  • Prajmaline
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Risperidone
  • Sematilide
  • Sertindole
  • Sotalol
  • Spiramycin
  • Sulfamethoxazole
  • Sultopride
  • Tedisamil
  • Telithromycin
  • Terfenadine
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Zolmitriptan
  • Zotepine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of dolasetron. Make sure you tell your doctor if you have any other medical problems.

Proper Use of Anzemet

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For prevention of nausea and vomiting after anticancer medicine:
      • Adults—100 milligrams (mg) given within one hour before the anticancer medicine is given.
      • Children 2 to 16 years of age—1.8 mg per kilogram (kg) (0.82 mg per pound) of body weight given within one hour before the anticancer medicine is given. The dose generally is not greater than 100 mg.
      • Children up to 2 years of age—Use and dose must be determined by your doctor.
    • For prevention of nausea and vomiting after surgery:
      • Adults—100 mg given within two hours before surgery.
      • Children 2 to 16 years of age—1.2 mg per kg (0.55 mg per pound) of body weight given within two hours before surgery. The dose generally is not greater than 100 mg.
      • Children up to 2 years of age—Use and dose must be determined by your doctor.
  • For injection dosage form:
    • For prevention of nausea and vomiting after anticancer medicine:
      • Adults—100 milligrams (mg) given into a vein approximately 30 minutes before the anticancer medicine is given.
      • Children 2 to 16 years of age—1.8 mg per kilogram (kg) (0.82 mg per pound) of body weight given into a vein approximately 30 minutes before the anticancer medicine is given. The dose generally is not greater than 100 mg.
      • Children up to 2 years of age—Use and dose must be determined by your doctor.
    • For prevention of nausea and vomiting after surgery:
      • Adults—12.5 mg given into a vein approximately 15 minutes before anesthesia (medicine to put you to sleep during surgery) is ended.
      • Children 2 to 16 years of age—0.35 mg per kg (0.16 mg per pound) of body weight given into a vein approximately 15 minutes before anesthesia (medicine to put you to sleep during surgery) is ended. The dose generally is not greater than 12.5 mg.
      • Children up to 2 years of age—Use and dose must be determined by your doctor.
    • For treatment of nausea and vomiting after surgery:
      • Adults—12.5 mg given into a vein as soon as nausea and vomiting start.
      • Children 2 to 16 years of age—0.35 mg per kg (0.16 mg per pound) of body weight given into a vein as soon as nausea and vomiting start. The dose generally is not greater than 12.5 mg.
      • Children up to 2 years of age—Use and dose must be determined by your doctor.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Anzemet Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common
  • High or low blood pressure
Rare
  • Blood in the urine
  • chest pain
  • decrease in amount of urine
  • fast heartbeat
  • pain
  • painful urination or trouble in urinating
  • severe stomach pain with nausea or vomiting
  • skin rash, hives, and/or itching
  • slow or irregular heartbeat
  • swelling of face
  • swelling of feet or lower legs
  • troubled breathing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Diarrhea
  • headache
Less common
  • Abdominal or stomach pain
  • dizziness or lightheadedness
  • fever or chills
  • unusual tiredness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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  • Anzemet Prescribing Information (FDA)
  • Anzemet Detailed Consumer Information (PDR)
  • Anzemet MedFacts Consumer Leaflet (Wolters Kluwer)
  • Anzemet Consumer Overview

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