Generic Name: pyridoxine (vitamin B6) (peer ih DOCK seen)Brand names: Nestrex, Vitelle Nestrex, Vitamin B6
Pyridoxine is vitamin B6. Vitamins are naturally occurring substances necessary for many processes in the body. Pyridoxine is important for the breakdown of protein, fats, and carbohydrates (sugars) in the foods we eat.
Pyridoxine is used to prevent and to treat deficiencies of pyridoxine that may be caused by an inadequate diet, medications, or genetic problems with metabolism.
Pyridoxine may also be used for purposes other than those listed in this medication guide.
Before taking pyridoxine, talk to your doctor, pharmacist, or health care professional if you have any other medical conditions, allergies, or if you take other medicines or other herbal/health supplements.Pyridoxine is in the FDA pregnancy category A. This means that pyridoxine is considered to be safe for use during pregnancy. Pyridoxine requirements increase during pregnancy. Talk to your doctor before taking pyridoxine if you are pregnant. Pyridoxine passes into breast milk. Pyridoxine requirements may increase during pregnancy. Doses larger than the recommended daily allowance should be used cautiously under the supervision of a doctor. Talk to your doctor before taking pyridoxine if you are breast-feeding.
Take pyridoxine exactly as directed by your doctor or as directed on the package. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.Take each dose with a full glass of water. Do not take more pyridoxine than is prescribed for you or than is directed on the package. Store pyridoxine at room temperature away from moisture and heat.
See also: Pyridoxine dosage in more detail
Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose.
Symptoms of a pyridoxine overdose may include poor coordination; staggering; numbness; decreased sensation to touch, temperature, and vibration; and tiredness for up to six months.
There are no restrictions on food, beverages, or activities while you are taking pyridoxine unless otherwise directed by your doctor.
Other side effects may also occur. Talk to your doctor if you experience
decreased sensation to touch, temperature, and vibration;
awkwardness of the hands;
numbness around the mouth; and
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Drug Induced Vitamin/Mineral Deficiency:
Drug Induced Neuritis: Cycloserine: 100 to 300 mg/day orally in divided doses.Isoniazid or penicillamine: 100 to 200 mg/day orally for 3 weeks or 25 to 100 mg/day for prophylaxis.Oral contraceptives: 25 to 30 mg/day orally.Acute Intoxication:Hydralazine: 25 mg/kg. One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.Isoniazid: 1 to 4 grams IV as a first dose, then 1 g IM every 30 minutes until the total required dose has been administered (given with other anticonvulsants as needed). The total dose administered should equal the amount of isoniazid ingested. Mushroom ingestion (genus Gyromitra): 25 mg/kg IV infused over 15 to 30 minutes. Repeat as needed to a maximum total daily dose of 15 to 20 g.
Usual Adult Dose for Dietary Supplement:
Pyridoxine Deficiency:2.5 to 10 mg daily until clinical signs of deficiency are corrected.
Usual Adult Dose for Anemia:
Sideroblastic, hereditary: 200 to 600 mg orally daily. If adequate response obtained, dose may be decreased to 30 to 50 mg orally daily.If therapeutic response is not obtained after 1 to 2 months of pyridoxine therapy, a different therapy should be considered.
Usual Adult Dose for Nausea/Vomiting:
Of Pregnancy:25 mg orally every 8 hours.
Usual Pediatric Dose for Drug Induced Vitamin/Mineral Deficiency:
Drug Induced Neuritis (cycloserine, isoniazid, hydralazine, penicillamine) :Treatment: 10 to 50 mg/day.Prophylaxis: 1 to 2 mg/kg/dayAcute Intoxication:Hydralazine: 25 mg/kg: One-third of the dose should be administered IM and the remainder administered as an IV infusion over 3 hours.Isoniazid: 1 to 4 grams IV administered as a first dose, then 1 g every 30 minutes until the total required dose has been administered. The total dose administered should equal the amount of isoniazid ingested.Mushroom ingestion (genus Gyromitra): 25 mg/kg IV. Repeat as needed up to a maximum total dose of 15 to 20 g.
Usual Pediatric Dose for Dietary Supplement:
Pyridoxine Deficiency:5 to 25 mg/day orally for 3 weeks followed by 1.5 to 2.5 mg/day from a multivitamin product.
Usual Pediatric Dose for Seizures:
Pyridoxine-dependent seizures:10 to 100 mg PO, IM, or IV initially, followed by 2 to 100 mg orally daily.
Before taking pyridoxine, tell your doctor if you are taking any of the following medications:
levodopa (Dopar, Larodopa, Sinemet, Atamet);
phenobarbital (Luminal, Solfoton); or
You may not be able to take pyridoxine, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
Drugs other than those listed here may also interact with pyridoxine. Talk to your doctor and pharmacist before taking or using any other prescription or over-the-counter medicines or herbal/health supplements.