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Drugs reference index «Quinupristin/Dalfopristin»


Generic Name: Quinupristin/Dalfopristin (kwin-ue-PRIS-tin/DAL-foe-PRIS-tin)Brand Name: Synercid

Quinupristin/Dalfopristin is used for:

Treating serious or life-threatening infections caused by certain bacteria. It may also be used for other conditions as determined by your doctor.

Quinupristin/Dalfopristin is a streptogramin antibiotic. It works by blocking the production of proteins needed by the bacteria to survive.

Do NOT use Quinupristin/Dalfopristin if:

  • you are allergic to any ingredient in Quinupristin/Dalfopristin or to streptogramins (eg, pristinamycin)

Contact your doctor or health care provider right away if this applies to you.

Before using Quinupristin/Dalfopristin :

Some medical conditions may interact with Quinupristin/Dalfopristin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of liver or kidney problems, stomach or bowel problems (eg, colitis, severe diarrhea caused by antibiotic use), HIV infection, or a heart condition

Some MEDICINES MAY INTERACT with Quinupristin/Dalfopristin . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Cyclosporine, midazolam, or nifedipine because the risk of side effects or toxic effects may be increased by Quinupristin/Dalfopristin
  • Many medicines (eg, used for allergies; angina, irregular heartbeat, or high blood pressure; anxiety or sleep; asthma; cancer; high cholesterol; HIV infection; infection; medicine to decrease the immune system; seizures; stomach problems) have possible side effects or toxic effects that may be increased by Quinupristin/Dalfopristin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Quinupristin/Dalfopristin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Quinupristin/Dalfopristin :

Use Quinupristin/Dalfopristin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Quinupristin/Dalfopristin is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Quinupristin/Dalfopristin at home, a health care provider will teach you how to use it. Be sure you understand how to use Quinupristin/Dalfopristin . Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Quinupristin/Dalfopristin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • To clear up your infection completely, use Quinupristin/Dalfopristin for the full course of treatment. Keep using it even if you feel better in a few days.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Quinupristin/Dalfopristin , contact your doctor right away.

Ask your health care provider any questions you may have about how to use Quinupristin/Dalfopristin .

Important safety information:

  • Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
  • If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
  • Quinupristin/Dalfopristin only works against bacteria; it does not treat viral infections (eg, the common cold).
  • Be sure to use Quinupristin/Dalfopristin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Long-term or repeated use of Quinupristin/Dalfopristin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
  • Quinupristin/Dalfopristin should not be used in CHILDREN younger than 16 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Quinupristin/Dalfopristin while you are pregnant. It is not known if Quinupristin/Dalfopristin is found in breast milk. If you are or will be breast-feeding while you use Quinupristin/Dalfopristin , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Quinupristin/Dalfopristin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Joint pain; muscle pain; nausea; pain, swelling, itching, or burning at the injection site; secondary infection.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; chest pain; confusion; dizziness; fast heartbeat; fatigue; loss of appetite; personality changes; seizures; severe muscle or joint pain; severe or persistent diarrhea; shakiness; stomach pain or cramps; sudden onset of a cold sweat; unexplained weight loss; vision changes; vomiting; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include loss of coordination; tremors; trouble breathing; vomiting.

Proper storage of Quinupristin/Dalfopristin :

Quinupristin/Dalfopristin is usually handled and stored by a health care provider. If you are using Quinupristin/Dalfopristin at home, store Quinupristin/Dalfopristin as directed by your pharmacist or health care provider. Keep Quinupristin/Dalfopristin out of the reach of children and away from pets.

General information:

  • If you have any questions about Quinupristin/Dalfopristin , please talk with your doctor, pharmacist, or other health care provider.
  • Quinupristin/Dalfopristin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Quinupristin/Dalfopristin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

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