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Drugs reference index «Quiphile»

Quiphile

Generic Name: quinine (Oral route)

KWYE-nine

Commonly used brand name(s):

In the U.S.

  • Qualaquin
  • Quinamm
  • Quiphile

Available Dosage Forms:

  • Tablet, Extended Release
  • Tablet
  • Capsule

Therapeutic Class: Musculoskeletal Agent

Chemical Class: Cinchona Alkaloid

Uses For Quiphile

Quinine is used to treat malaria. This medicine usually is given with one or more other medicines for malaria.

Quinine may also be used for other problems as determined by your doctor. Do not confuse quinine with quinidine, a different medicine that is used for heart problems.

Quinine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, quinine is used in certain patients with the following medical conditions:

  • Babesiosis (infection caused by parasites)

Before Using Quiphile

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

This medicine has been used to treat malaria in children and, in effective doses, has not been shown to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of quinine in the elderly with use in other age groups.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Astemizole
  • Aurothioglucose
  • Dronedarone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Asenapine
  • Digoxin
  • Droperidol
  • Iloperidone
  • Lapatinib
  • Lumefantrine
  • Mefloquine
  • Methadone
  • Pancuronium
  • Ranolazine
  • Sunitinib

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cyclosporine
  • Rifapentine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blackwater fever, history of, or
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency or
  • Purpura, or history of (purplish or brownish-red discoloration of skin)—Patients with a history of blackwater fever, G6PD deficiency, or purpura may have an increased risk of side effects affecting the blood
  • Heart disease—Quinine can cause side effects affecting the heart, usually at higher doses
  • Hypoglycemia—Quinine may cause low blood sugar
  • Myasthenia gravis—Quinine may increase muscle weakness in patients with myasthenia gravis

Proper Use of quinine

This section provides information on the proper use of a number of products that contain quinine. It may not be specific to Quiphile. Please read with care.

Take this medicine only as directed. Do not take more of it, do not take it more often, and do not take it for a longer time than recommended on the label, unless otherwise directed by your doctor. To do so may increase the chance of side effects.

Take this medicine with or after meals to lessen possible stomach upset, unless otherwise directed by your doctor. If you are to take this medicine at bedtime, take it with a snack or with a glass of water, milk, or other beverage.

For patients taking quinine for malaria:

  • To help clear up your infection completely, keep taking this medicine for the full time of treatment, even if you begin to feel better after a few days. If you stop taking this medicine too soon, your symptoms may return. Do not miss any doses.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For treatment of malaria:
    • Adults and teenagers: 600 to 650 mg every eight hours for at least three days. This medicine must be taken with other medicine to treat malaria.
    • Children: Dose must be determined by the doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Quiphile

Quinine may cause blurred vision or a change in color vision. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not able to see well. If these reactions are especially bothersome, check with your doctor.

Quiphile Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Abdominal or stomach cramps or pain
  • diarrhea
  • nausea
  • vomiting
Less common
  • Anxiety
  • behavior change, similar to drunkenness
  • black, tarry stools
  • blood in urine or stools
  • blurred vision
  • cold sweats
  • confusion
  • convulsions (seizures) or coma
  • cool pale skin
  • cough or hoarseness
  • difficulty in concentrating
  • drowsiness
  • excessive hunger
  • fast heartbeat
  • fever or chills
  • headache
  • lower back or side pain
  • nervousness
  • nightmares
  • painful or difficult urination
  • pinpoint red spots on skin
  • restless sleep
  • shakiness
  • slurred speech
  • sore throat
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Rare
  • Difficulty in breathing and/or swallowing
  • disturbed color perception
  • double vision
  • hives
  • increased sweating
  • muscle aches
  • night blindness
  • reddening of the skin, especially around ears
  • ringing or buzzing in ears
  • swelling of eyes, face, or inside of nose
Signs and symptoms of overdose
  • Blindness
  • chest pain
  • dizziness
  • double vision
  • fainting
  • lightheadedness
  • rapid or irregular heartbeat
  • sleepiness

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

  • Blurred vision or change in vision

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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