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Drugs reference index «repaglinide»

repaglinide


repaglinide

Generic Name: repaglinide (oral) (re PAG li nide)Brand Names: Prandin

What is repaglinide?

Repaglinide is an oral diabetes medicine that helps control blood sugar levels. This medication lowers blood sugar by causing the pancreas to produce insulin.

Repaglinide is used together with diet and exercise to treat type 2 (non-insulin dependent) diabetes. Other diabetes medicines are sometimes used in combination with repaglinide if needed.

Repaglinide may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about repaglinide?

Do not use this medication if you are allergic to repaglinide, if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). You should not use repaglinide together with gemfibrozil (Lopid) or NPH insulin (such as isophane insulin).

Take care not to let your blood sugar get too low, causing hypoglycemia. You may have hypoglycemia if you skip a meal, exercise too long, drink alcohol, or are under stress.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them. Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. Severe hypoglycemia may cause loss of consciousness, seizures, or death. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection. If your blood sugar gets too high (hyperglycemia), you may feel very thirsty or hungry. You may also urinate more than usual. Call your doctor right away if you have any symptoms of hyperglycemia.

Repaglinide is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

It is important to take repaglinide regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

What should I discuss with my doctor before taking repaglinide?

Do not use this medication if you are allergic to repaglinide, if you have type 1 diabetes, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). You should not use repaglinide together with gemfibrozil (Lopid) or NPH insulin (such as isophane insulin).

Before taking repaglinide, tell your doctor if you are allergic to any medications, or if you have liver disease. You may need a dose adjustment or special tests to safely take this medication.

FDA pregnancy category C. It is not known whether repaglinide is harmful to an unborn baby. Before using this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether repaglinide passes into breast milk or if it could be harmful to a nursing baby. Do not take repaglinide without telling your doctor if you are breast-feeding a baby.

How should I take repaglinide?

Take repaglinide exactly as it was prescribed for you. Do not take the medication in larger or smaller amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription.

Your dose needs may change if you are ill, if you have a fever or infection, or if you have surgery or a medical emergency. Do not change your dose of repaglinide without first talking to your doctor. Take this medicine with a full glass of water.

Repaglinide is usually taken 2 to 4 times daily, within 30 minutes before eating a meal. Follow your doctor's instructions. If you skip a meal, do not take your dose of repaglinide. Wait until your next meal.

Take care not to let your blood sugar get too low, causing hypoglycemia. You may have hypoglycemia if you skip a meal, exercise too long, drink alcohol, or are under stress.

Know the signs of low blood sugar (hypoglycemia) and how to recognize them. Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. Severe hypoglycemia may cause loss of consciousness, seizures, or death. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.

Your blood sugar will need to be checked on a regular basis. You may also need other blood tests at your doctor's office. Do not miss any appointments.

Repaglinide is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

It is important to take repaglinide regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Store repaglinide at room temperature away from moisture and heat.

See also: Repaglinide dosage in more detail

What happens if I miss a dose?

Take the missed dose as soon as you remember, but only if you are getting ready to eat a meal. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include hunger, nausea, anxiety, cold sweats, weakness, drowsiness, loss of consciousness, and coma.

What should I avoid while taking repaglinide?

Avoid drinking alcohol while taking repaglinide. Alcohol can lower your blood sugar.

Repaglinide side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
  • seizure (convulsions);

  • severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;

  • pale or yellowed skin, dark colored urine, fever, confusion or weakness; or

  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash.

Less serious side effects may include:

  • runny or stuffy nose, sneezing, cough, cold or flu symptoms;

  • diarrhea, nausea;

  • back pain, headache;

  • dizziness;

  • blurred vision;

  • joint pain; or

  • temporary hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Repaglinide Dosing Information

Usual Adult Dose for Diabetes Mellitus Type II:

Patients who have not previously taken an oral hypoglycemic or patients who have an HbA1c less than 8%: 0.5 mg orally with meals.Patients previously treated with an oral hypoglycemic or patients who have an HbA1c greater than or equal to 8%: 1 to 2 mg orally with meals.All doses should be taken within 15 minutes of the meal or as much as 30 minutes before the meal. If a meal is skipped, the repaglinide dose should also be skipped. Likewise, if a meal is added during the day, so should a dose of repaglinide.

What other drugs will affect repaglinide?

Tell your doctor about all other medications you use, especially:
  • cyclosporine (Gengraf, Neoral, Sandimmune);

  • St. John's wort;

  • an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek);

  • an antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Nizoral);

  • a barbiturate such as phenobarbital (Solfoton);

  • heart or blood pressure medication such as diltiazem (Cartia, Cardizem), nicardipine (Cardene), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others;

  • HIV/AIDS medicine such as delavirdine (Rescriptor), efavirenz (Sustiva), fosamprenavir (Lexiva), indinavir (Crixivan), ritonavir (Norvir), and others;

  • rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), or rifapentine (Priftin); or

  • seizure medication such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), primidone (Mysoline), and others.

You may be more likely to have hyperglycemia (high blood sugar) if you are taking repaglinide with other drugs that raise blood sugar:

  • isoniazid;

  • diuretics (water pills);

  • steroids (prednisone and others);

  • phenothiazines (Compazine and others);

  • thyroid medicine (Synthroid and others);

  • birth control pills and other hormones;

  • seizure medicines (Dilantin and others); and

  • diet pills or medicines to treat asthma, colds or allergies.

You may be more likely to have hypoglycemia (low blood sugar) if you are taking repaglinide with other drugs that lower blood sugar, such as:

  • probenecid (Benemid);

  • a blood thinner (warfarin, Coumadin);

  • some nonsteroidal anti-inflammatory drugs (NSAIDs);

  • aspirin or other salicylates (including Pepto-Bismol);

  • sulfa drugs (Bactrim, Gantanol, Gantrisin, Septra, SMX-TMP, and others);

  • a monoamine oxidase inhibitor (MAOI); or

  • beta-blockers (Tenormin and others).

This list is not complete and there may be other drugs that can interact with repaglinide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about repaglinide.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 6.01. Revision Date: 10/09/2009 2:38:42 PM.
  • repaglinide Advanced Consumer (Micromedex) - Includes Dosage Information
  • Repaglinide Professional Patient Advice (Wolters Kluwer)
  • Repaglinide MedFacts Consumer Leaflet (Wolters Kluwer)
  • Repaglinide Detailed Consumer Information (PDR)
  • Prandin Prescribing Information (FDA)
  • Prandin Consumer Overview

See Also...

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