Generic Name: methotrexate (oral) (meth oh TREX ate)Brand Names: Rheumatrex Dose Pack, Trexall
Methotrexate interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.
Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. Methotrexate is also used to treat severe psoriasis and rheumatoid arthritis.
Methotrexate is usually given after other medications have been tried without successful treatment of symptoms.
Methotrexate may also be used for other purposes not listed in this medication guide.
To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled appointments.
There are many other medicines that can interact with methotrexate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.
alcoholism or cirrhosis of the liver;
a blood cell disorder such as anemia (lack of red blood cells) or leukopenia (lack of white blood cells);
a bone marrow disorder; or
if you are breast-feeding a baby.
Methotrexate is sometimes used to treat cancer even when patients do have one of the conditions listed above. Your doctor will decide if this treatment is right for you.
If you have any of these other conditions, you may need a dose adjustment or special tests to safely take methotrexate:
lung disease or pneumonia;
any type of infection; or
if you are receiving radiation treatments.
Use birth control to prevent pregnancy while you are using methotrexate, whether you are a man or a woman. Methotrexate use by either parent may cause birth defects.
Before you start taking methotrexate, your doctor may want you to have a pregnancy test to make sure you are not pregnant.If you are a man, use a condom to keep from causing a pregnancy while you are using methotrexate. Continue using condoms for at least 90 days after your treatment ends. If you are a woman, use an effective form of birth control while you are taking methotrexate, and for at least one cycle of ovulation after your treatment ends. Do not give this medicine to a child without the advice of a doctor.
Older adults may be more likely to have side effects from this medication.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.You must use the correct dose of methotrexate for your condition. Methotrexate is usually taken once or twice per week and not every day. Follow the directions on your prescription label. Some people have died after taking methotrexate every day by accident. Ask your doctor if you have any questions about your dose of methotrexate or how often to take it.
This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
It is important to use methotrexate regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested, and you may need an occasional liver biopsy. Do not miss any scheduled appointments.Store methotrexate at room temperature away from moisture and heat.
Call your doctor if you miss a dose of methotrexate.
Overdose symptoms may include pale skin, easy bruising or bleeding, unusual weakness, mouth sores, nausea, vomiting, black or bloody stools, coughing up blood or vomit that looks like coffee grounds, and urinating less than usual or not at all.
dry cough, shortness of breath;
diarrhea, vomiting, white patches or sores inside your mouth or on your lips;
blood in your urine or stools;
urinating less than usual or not at all;
fever, chills, body aches, flu symptoms;
sore throat and headache with a severe blistering, peeling, and red skin rash;
pale skin, easy bruising or bleeding, weakness; or
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
nausea, vomiting, upset stomach;
dizziness, tired feeling;
bleeding of your gums; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking methotrexate, tell your doctor if you are using any of the following drugs:
hydroxychloroquine (Plaquenil, Quineprox);
retinol, tretinoin (Retin-A), isotretinoin (Accutane);
steroids (prednisone and others);
sulfa drugs such as Azulfidine, Bactrim, or Septra;
tetracycline (Brodspec, Panmycin, Sumycin, Tetracap);
theophylline (Elixophyllin, Slo-Bid, Theobid, Theo-Dur);
gold treatments such as auranofin (Ridura);
oral diabetes medications such as acetohexamide (Dymelor), chlorpropamide (Diabinese), glipizide (Glucotrol), glimepiride (Amaryl), or tolbutamide (Orinase);
a penicillin antibiotic such as ampicillin (Principen), amoxicillin (Amoxil, Trimox), dicloxacillin (Dynapen), nafcillin (Unipen), oxacillin (Bactocill), penicillamine (Cuprimine, Depen), or Bee-Pen, Pen-Vee K, Veetids;
salicylates such as aspirin, Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others; or
NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), naproxen (Aleve, Naprosyn), meloxicam (Mobic), piroxicam (Feldene), and others.
This list is not complete and there may be other drugs that can interact with methotrexate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.