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Drugs reference index «Rifadin»

Rifadin


Rifadin

Generic Name: rifampin (Oral route, Intravenous route)

rif-AM-pin

Commonly used brand name(s):

In the U.S.

  • Rifadin
  • Rifadin IV
  • Rimactane

Available Dosage Forms:

  • Capsule
  • Tablet
  • Powder for Solution
  • Syrup

Therapeutic Class: Antitubercular

Chemical Class: Rifamycin

Uses For Rifadin

Rifampin is used to treat certain bacterial infections.

Rifampin is used with other medicines to treat tuberculosis (TB). Rifampin is also taken by itself by patients who may carry meningitis bacteria in their nose and throat (without feeling sick) and may spread these bacteria to others. This medicine may also be used for other problems as determined by your doctor. However, rifampin will not work for colds, flu, or other virus infections.

To help clear up your tuberculosis (TB) completely, you must keep taking this medicine for the full time of treatment, even if you begin to feel better. This is very important. It is also important that you do not miss any doses.

Rifampin is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, rifampin is used in certain patients with the following medical conditions:

  • Atypical mycobacterial infections, such as Mycobacterium avium complex (MAC)
  • Leprosy (Hansen's disease)
  • Prevention of Haemophilus influenzae infection
  • Treatment of serious staphylococcal (bacterial) infections

Before Using Rifadin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

This medicine has been tested in children and, in effective doses, has not been shown to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of rifampin in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Atazanavir
  • Darunavir
  • Fosamprenavir
  • Lopinavir
  • Ranolazine
  • Saquinavir
  • Tipranavir
  • Voriconazole

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amiodarone
  • Amprenavir
  • Atovaquone
  • Cyclosporine
  • Dasatinib
  • Delavirdine
  • Dronedarone
  • Efavirenz
  • Erlotinib
  • Ethionamide
  • Etravirine
  • Imatinib
  • Indinavir
  • Irinotecan
  • Isoniazid
  • Itraconazole
  • Ixabepilone
  • Lapatinib
  • Lorcainide
  • Maraviroc
  • Mycophenolate Mofetil
  • Nelfinavir
  • Nevirapine
  • Nilotinib
  • Pazopanib
  • Praziquantel
  • Pyrazinamide
  • Quetiapine
  • Ritonavir
  • Romidepsin
  • Sunitinib
  • Tacrolimus
  • Telithromycin
  • Temsirolimus
  • Tolvaptan

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acetyldigoxin
  • Anisindione
  • Aprepitant
  • Atorvastatin
  • Betamethasone
  • Bexarotene
  • Bosentan
  • Buspirone
  • Carbamazepine
  • Carvedilol
  • Caspofungin
  • Chloramphenicol
  • Chlorpropamide
  • Citalopram
  • Clofibrate
  • Clozapine
  • Cortisone
  • Deferasirox
  • Dexamethasone
  • Dicumarol
  • Digoxin
  • Diltiazem
  • Disopyramide
  • Doxycycline
  • Eltrombopag
  • Enalaprilat
  • Enalapril Maleate
  • Ethinyl Estradiol
  • Etonogestrel
  • Everolimus
  • Fentanyl
  • Fesoterodine
  • Fluconazole
  • Fludrocortisone
  • Fosaprepitant
  • Fosphenytoin
  • Gefitinib
  • Gliclazide
  • Glyburide
  • Haloperidol
  • Isradipine
  • Ketoconazole
  • Lamotrigine
  • Leflunomide
  • Levomethadyl
  • Levonorgestrel
  • Levothyroxine
  • Linezolid
  • Losartan
  • Medroxyprogesterone
  • Mefloquine
  • Mestranol
  • Methadone
  • Methylprednisolone
  • Metoprolol
  • Morphine
  • Morphine Sulfate Liposome
  • Moxifloxacin
  • Nifedipine
  • Nisoldipine
  • Norelgestromin
  • Norethindrone
  • Norgestrel
  • Oxycodone
  • Phenprocoumon
  • Phenytoin
  • Pioglitazone
  • Pirmenol
  • Pitavastatin
  • Prednisolone
  • Prednisone
  • Propafenone
  • Raltegravir
  • Repaglinide
  • Rofecoxib
  • Rosiglitazone
  • Sertraline
  • Simvastatin
  • Sirolimus
  • Tadalafil
  • Tamoxifen
  • Theophylline
  • Tocainide
  • Triazolam
  • Trimetrexate
  • Valproic Acid
  • Warfarin
  • Zaleplon
  • Zidovudine
  • Zolpidem

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse (or history of) or
  • Liver disease—There may be an increased chance of side effects affecting the liver in patients with a history of alcohol abuse or liver disease

Proper Use of rifampin

This section provides information on the proper use of a number of products that contain rifampin. It may not be specific to Rifadin. Please read with care.

Rifampin is best taken with a full glass (8 ounces) of water on an empty stomach (either 1 hour before or 2 hours after a meal). However, if this medicine upsets your stomach, your doctor may want you to take it with food.

For patients unable to swallow capsules:

  • Contents of the capsules may be mixed with applesauce or jelly. Be sure to take all the food to get the full dose of medicine.
  • Your pharmacist can prepare an oral liquid form of this medicine if needed. The liquid form may be kept at room temperature or in the refrigerator. Follow the directions on the label. Shake the bottle well before using. Do not use after the expiration date on the label. The medicine may not work properly after that date. In addition, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

To help clear up your tuberculosis (TB) infection completely, it is very important that you keep taking this medicine for the full time of treatment, even if you begin to feel better after a few weeks. You may have to take it every day for as long as 1 to 2 years or more. It is important that you do not miss any doses.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (capsules) and injection dosage form:
    • For the treatment of tuberculosis (TB):
      • Adults and older children—600 milligrams (mg) once a day. Your doctor may instruct you to take 600 mg two times a week or three times a week. Rifampin must be taken with other medicines to treat tuberculosis.
      • Infants and children—Dose is based on body weight and will be determined by your doctor. Rifampin is usually taken once a day. Your doctor may instruct you to take rifampin two times a week or three times a week. Rifampin must be taken with other medicines to treat tuberculosis.
    • For the treatment of patients in contact with the meningitis bacteria:
      • Adults and older children—600 mg once a day for four days.
      • Infants and children—Dose is based on body weight and will be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If this medicine is taken on an irregular schedule, side effects may occur more often and may be more serious than usual. If you have any questions about this, check with your health care professional.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Rifadin

It is very important that your doctor check your progress at regular visits.

If your symptoms do not improve within 2 to 3 weeks, or if they become worse, check with your doctor.

Oral contraceptives (birth control pills) containing estrogen may not work properly if you take them while you are taking rifampin. Unplanned pregnancies may occur. You should use a different means of birth control while you are taking rifampin. If you have any questions about this, check with your health care professional.

Liver problems may be more likely to occur if you drink alcoholic beverages regularly while you are taking this medicine. Also, the regular use of alcohol may keep this medicine from working properly. Therefore, you should not drink alcoholic beverages while you are taking this medicine .

If this medicine causes you to feel very tired or very weak or causes a loss of appetite, nausea, or vomiting, stop taking it and check with your doctor immediately. These may be early warning signs of more serious problems that could develop later.

Rifampin will cause the urine, stool, saliva, sputum, sweat, and tears to turn reddish-orange to reddish-brown. This is to be expected while you are taking this medicine. This effect may cause soft contact lenses to become permanently discolored. Standard cleaning solutions may not take out all the discoloration. Therefore, it is best not to wear soft contact lenses while taking this medicine. This condition will return to normal once you stop taking this medicine. Hard contact lenses are not discolored by rifampin. If you have any questions about this, check with your doctor.

Rifampin can lower the number of white blood cells in your blood temporarily, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. These problems may result in a greater chance of getting certain infections, slow healing, and bleeding of the gums. Be careful when using a regular toothbrush, dental floss, or a toothpick. Dental work should be delayed until your blood counts have returned to normal. Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment.

Before you have any medical tests, tell the doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Rifadin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common
  • Chills
  • difficult breathing
  • dizziness
  • fever
  • headache
  • itching
  • muscle and bone pain
  • shivering
  • skin rash and redness
Rare
  • Bloody or cloudy urine
  • greatly decreased frequency of urination or amount of urine
  • loss of appetite
  • nausea or vomiting
  • sore throat
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin
Signs and symptoms of overdose
  • Itching over the whole body
  • mental changes
  • reddish-orange color of skin, mouth, and eyeballs
  • swelling around the eyes or the whole face

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Diarrhea
  • stomach cramps
Less common
  • Sores on mouth or tongue

This medicine commonly causes reddish-orange to reddish-brown discoloration of urine, stool, saliva, sputum, sweat, and tears. This side effect does not usually need medical attention.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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  • Rifadin Prescribing Information (FDA)
  • Rifadin MedFacts Consumer Leaflet (Wolters Kluwer)
  • Rifadin Concise Consumer Information (Cerner Multum)
  • Rifampin Professional Patient Advice (Wolters Kluwer)
  • Rifampin Injection Prescribing Information (FDA)
  • Rifadin IV MedFacts Consumer Leaflet (Wolters Kluwer)

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