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Drugs reference index «Rifampin»


Generic Name: Rifampin (rif-am-pin)Brand Name: Rifadin IV

Rifampin is used for:

The treatment of all forms of tuberculosis and the treatment of some people who have meningitis without symptoms. It may also be used for other conditions as determined by your doctor.

Rifampin is an antituberculosis agent. It works by killing or stopping the growth of tuberculosis bacteria.

Do NOT use Rifampin if:

  • you are allergic to any ingredient in Rifampin or to any rifamycin (eg, rifabutin)
  • you have porphyria
  • you are taking HIV protease inhibitors (eg, ritonavir) or voriconazole

Contact your doctor or health care provider right away if any of these apply to you.

Before using Rifampin :

Some medical conditions may interact with Rifampin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are alcohol dependent or have alcohol withdrawal syndrome
  • if you have jaundice, cirrhosis, other liver disease, or inflammation or obstruction of the bile ducts
  • if you have had abnormal liver function tests
  • if you have the blood disease porphyria or intestinal problems (eg, pseudomembranous colitis)

Some MEDICINES MAY INTERACT with Rifampin . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Many prescription and nonprescription medicines (eg, used for infections, inflammation, aches and pains, high blood pressure, high cholesterol, seizures), multivitamin products, herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort), HIV protease inhibitors (eg, ritonavir), isoniazid, itraconazole, and voriconazole may interact with Rifampin , increasing the risk of side effects.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Rifampin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Rifampin :

Use Rifampin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Rifampin is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Rifampin at home, a health care provider will teach you how to use it. Be sure you understand how to use Rifampin . Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Rifampin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • To clear up your infection completely, use Rifampin for the full course of treatment. Keep using it even if you feel better in a few days.
  • Rifampin works best if it is taken at the same time each day.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Rifampin , take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Rifampin .

Important safety information:

  • Rifampin may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Rifampin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Rifampin only works against bacteria; it does not treat viral infections (eg, the common cold).
  • Be sure to use Rifampin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Rifampin may produce a reddish coloration of your urine, sweat, saliva, and tears. Rifampin may also permanently stain soft contact lenses.
  • Rifampin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Rifampin .
  • Hormonal birth control (eg, birth control pills) may not work as well while you are using Rifampin . To prevent pregnancy, use an extra form of birth control (eg, condoms).
  • Lab tests, such as complete blood counts and liver function tests, may be performed while you use Rifampin . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Rifampin with caution in the ELDERLY; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Rifampin while you are pregnant. Rifampin is found in breast milk. Do not breast-feed while taking Rifampin .

Possible side effects of Rifampin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cramps; diarrhea; dizziness; drowsiness; gas; headache; heartburn; menstrual changes; stomach pain or bloating.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; decreased urination; fever, chills, or persistent sore throat; general feeling of discomfort; joint pain or swelling; loss of appetite; mental or mood changes; nausea or vomiting; pain, swelling, or redness at the injection site; red, swollen, or blistered skin; severe stomach pain; unusual bruising or bleeding; vision changes; wheezing; yellowing of eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include abdominal pain; increasing lethargy; itching; nausea; severe headache; swelling of the face; vomiting. Unconsciousness may occur in severe liver disease. Liver enlargement and yellowing of eyes and skin may develop rapidly. Lowered blood pressure, heart abnormalities, and seizures may develop.

Proper storage of Rifampin :

Rifampin is usually handled and stored by a health care provider. If you are using Rifampin at home, store Rifampin as directed by your pharmacist or health care provider. Keep Rifampin out of the reach of children and away from pets.

General information:

  • If you have any questions about Rifampin , please talk with your doctor, pharmacist, or other health care provider.
  • Rifampin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • If using Rifampin for an extended period of time, obtain refills before your supply runs out.

This information is a summary only. It does not contain all information about Rifampin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Rifampin Injection Prescribing Information (FDA)
  • Rifampin Professional Patient Advice (Wolters Kluwer)
  • rifampin Oral, Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information
  • rifampin Concise Consumer Information (Cerner Multum)
  • Rifadin Prescribing Information (FDA)

See Also...

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