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Drugs reference index «Rifapentine»



Generic Name: Rifapentine (RIF-ah-pen-teen)Brand Name: Priftin

Rifapentine is used for:

Treating tuberculosis (TB). It is used along with other medicines.

Rifapentine is a rifamycin antibiotic. It works by killing or stopping growth of TB organisms.

Do NOT use Rifapentine if:

  • you are allergic to any ingredient in Rifapentine or to rifamycins (eg, rifampin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Rifapentine :

Some medical conditions may interact with Rifapentine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver disease, abnormal liver function tests, the blood disease porphyria, or pseudomembranous colitis

Some MEDICINES MAY INTERACT with Rifapentine . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • HIV protease inhibitors (eg, indinavir) because the risk of side effects, including heart, blood, or nerve problems, may be increased
  • Many prescription and nonprescription medicines (eg, used for infections, HIV, heart problems, irregular heartbeat, asthma, inflammation, pain, high blood pressure, diabetes, birth control, blood thinning, high cholesterol, thyroid replacement, seizures, and other conditions) may interact with Rifapentine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Rifapentine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Rifapentine :

Use Rifapentine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Rifapentine may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Take Rifapentine at least 1 hour before or 2 hours after antacids.
  • If you are giving Rifapentine to a child or you have malnourishment, alcoholism, or diabetes, ask your doctor about taking Rifapentine with vitamin B6.
  • To clear up your infection completely, continue taking Rifapentine for the full course of treatment, even if you feel better. Do not miss any doses.
  • It may take several months for Rifapentine to work. Do not stop using Rifapentine without checking with your doctor.
  • If you miss a dose of Rifapentine , take it as soon as possible. If it is less than 72 hours until your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Rifapentine .

Important safety information:

  • Rifapentine may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Rifapentine . Using Rifapentine alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Rifapentine may color the urine, stools, sweat, saliva, or tears orange or red. Rifapentine may permanently stain contact lenses.
  • Rifapentine is effective only against bacteria. It is not effective for treating viral infections (eg, the common cold).
  • It is important to use Rifapentine for the full course of treatment. Failure to do so may decrease the effectiveness of Rifapentine and increase the risk that the bacteria will no longer be sensitive to Rifapentine and will not be able to be treated by this or certain other antibiotics in the future.
  • Long-term or repeated use of Rifapentine may cause a second infection. Your doctor may want to change your medicine to treat the second infection. Contact your doctor if signs of a second infection occur.
  • If severe diarrhea, stomach pain/cramps, or bloody stools occur, contact your doctor immediately. This could be a symptom of a serious side effect requiring immediate medical attention. Do not treat diarrhea without consulting your doctor.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Rifapentine .
  • LAB TESTS, including liver function, complete blood cell counts, platelet counts, and bilirubin levels, may be required to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Rifapentine is not recommended for use in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed.
  • Rifapentine may decrease the effectiveness of your hormonal birth control (eg, birth control pills). To prevent pregnancy, be sure to use an additional form of birth control (eg, condoms) while using Rifapentine .
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Rifapentine during pregnancy. It is unknown if this drug is excreted in breast milk. Do not breast-feed while taking Rifapentine .

Possible side effects of Rifapentine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Acne; discoloration of body fluids; dizziness; headache; pain; stomach pain; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); appetite loss; dark urine; diarrhea; fever; general body discomfort; joint pain or swelling; nausea; pale stools; sore throat; unusual fatigue; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include headache; heartburn; increased urinary frequency.

Proper storage of Rifapentine :

Store Rifapentine below 77 degrees F (25 degrees C) in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep Rifapentine out of the reach of children and away from pets.

General information:

  • If you have any questions about Rifapentine , please talk with your doctor, pharmacist, or other health care provider.
  • Rifapentine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Rifapentine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Rifapentine Professional Patient Advice (Wolters Kluwer)
  • rifapentine Concise Consumer Information (Cerner Multum)
  • rifapentine Advanced Consumer (Micromedex) - Includes Dosage Information
  • Priftin Prescribing Information (FDA)

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