Romiplostim Generic Name:
Romiplostim (roe-mi-PLOE-stim)Brand Name:
Romiplostim is used for:
Treating low platelets (thrombocytopenia) in certain patients with chronic immune thrombocytopenia purpura (ITP).
Romiplostim is a thrombopoietin (TPO) mimetic protein. It works by helping the bone marrow to increase the number of clot-forming cells (platelets) in the blood. This helps the blood to clot more normally and reduce your risk for excessive or severe bleeding.
Do NOT use Romiplostim if:
- you are allergic to any ingredient in Romiplostim
Contact your doctor or health care provider right away if any of these apply to you.
Before using Romiplostim :
Some medical conditions may interact with Romiplostim . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have had your spleen removed (splenectomy)
- if you have blood clotting problems, bleeding problems, or a history of heart attack, stroke, or blood clots in your veins (eg, pulmonary embolism)
- if you have kidney problems, liver problems, bone marrow problems, a precancerous condition of the blood (eg, myelodysplastic syndrome [MDS]) or blood cancer (eg, leukemia)
- if you are also taking an anticoagulant or antiplatelet medicine
Some MEDICINES MAY INTERACT with Romiplostim . However, no specific interactions with Romiplostim are known at this time.
Ask your health care provider if Romiplostim may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Romiplostim :
Use Romiplostim as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Romiplostim comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again before each time you use Romiplostim .
- Romiplostim is given as an injection at your doctor's office, hospital, or clinic. You should receive Romiplostim only under direct medical supervision by a doctor experienced in the use of Romiplostim .
- If you miss a dose of Romiplostim , contact your doctor right away.
Ask your health care provider any questions you may have about how to use Romiplostim .
Important safety information:
- Romiplostim may worsen precancerous conditions of the blood (eg, MDS) and may increase the risk of developing blood cancer. Tell your doctor if you have any of these conditions before you use Romiplostim .
- Romiplostim may increase the risk of high platelet counts and blood clots. Your doctor will perform tests to check for these conditions. Discuss any questions or concerns with your doctor.
- You may be at greater risk for low platelet counts and bleeding after you stop Romiplostim , especially if you also take anticoagulants or antiplatelet medicines. Check with your doctor right away if you notice any unusual bleeding or bruising.
- Lab tests, including complete blood cell counts and bone marrow tests, may be performed while you use Romiplostim and for at least 2 weeks after you stop using it. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- Use Romiplostim with caution in the ELDERLY; they may be more sensitive to its effects.
- Romiplostim should be used with extreme caution in CHILDREN; safety and effectiveness in these children have not been confirmed.
- PREGNANCY AND BREAST-FEEDING: It is not known if Romiplostim can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Romiplostim while you are pregnant. It is not known if Romiplostim is found in breast milk. Do not breast-feed while taking Romiplostim .
Possible side effects of Romiplostim :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Dizziness; headache; indigestion; joint pain; muscle tenderness or weakness; shoulder pain; stomach pain or upset; trouble sleeping.Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blurred vision; chest pain; leg or arm pain; numbness or tingling of the hands and feet; one-sided weakness; severe or persistent dizziness or headache; unusual bruising or bleeding; unusual weakness or tiredness; vomit that looks like coffee grounds.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.Proper storage of Romiplostim :
Romiplostim is handled and stored by a health care provider.
- If you have any questions about Romiplostim , please talk with your doctor, pharmacist, or other health care provider.
- Romiplostim is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Romiplostim . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
- Romiplostim Professional Patient Advice (Wolters Kluwer)
- romiplostim Subcutaneous Advanced Consumer (Micromedex) - Includes Dosage Information
- Nplate Prescribing Information (FDA)
- Nplate Consumer Overview