Generic Name: rilonacept (ril ON a sept)Brand Names: Arcalyst
Rilonacept is used to treat some of the symptoms of rare genetic conditions such as Familial Cold Auto-inflammatory Syndrome (FCAS) or Muckle-Wells Syndrome (MWS).
FCAS and MWS are inflammatory disorders in which the body develops certain symptoms without a known cause (such as virus, bacteria, or illness). These symptoms include fever, chills, fatigue, and joint pain. More serious symptoms may involve the bones and joints, the central nervous system (deafness, vision loss, mental impairment), or major organs such as the kidneys.Rilonacept may treat or prevent the symptoms of Familial Cold Auto-inflammatory Syndrome (FCAS) or Muckle-Wells Syndrome (MWS). However, this medication is not a cure for these inherited conditions.
Rilonacept may also be used for other purposes not listed in this medication guide.
You should not use this medication if you are allergic to rilonacept, or if you have any type of infection. Before using rilonacept, tell your doctor if you have a history of tuberculosis.Do not receive a "live" vaccine while you are being treated with rilonacept. The live vaccine may not work as well during this time, and may not fully protect you from disease. Avoid coming into contact with anyone who has recently received a live vaccine. There is a chance that the virus could be passed on to you. Make sure you are current on all vaccines before you start treatment with rilonacept. To be sure this medication is not causing harmful effects, your blood may need to be tested on a regular basis. Do not miss any follow-up visits to your doctor for blood or urine tests.
Contact your doctor at once if you develop signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, or unusual weakness.
Do not use this medication more often than once per week unless your doctor has told you to.
If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before using rilonacept, tell your doctor if you have a history of tuberculosis.FDA pregnancy category C. Rilonacept may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether rilonacept passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not use this medication in a child younger than 12 years old unless your doctor has told you to.
Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.
Rilonacept is given as an injection under the skin of your stomach, thigh, or upper arm. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to inject your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.
Rilonacept is usually given to adults in two injections at a time, each on a different place on your body. The two injections are then given once per week.
Children may be given one or two injections at a time once per week. Follow your doctor's instructions.Do not use this medication more often than once per week unless your doctor has told you to.
You will need to mix rilonacept with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medication. After mixing rilonacept with a diluent, you must use it within 3 hours.
Each vial (bottle) of rilonacept is for a single use only. Throw the vial away after one use, even if there is still medication left in it.
Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.To be sure this medication is not causing harmful effects, your blood may need to be tested on a regular basis. Do not miss any follow-up visits to your doctor for blood or urine tests.
Contact your doctor at once if you develop signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, or unusual weakness.Store the unmixed powder medicine in the refrigerator and protected from light. Do not freeze. Keep each vial in the original container until you are ready to mix your medicine.
Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.
Symptoms of a rilonacept overdose are not known.
new signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding, or unusual weakness;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
fever and chills with headache, neck stiffness, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions); or
pain or burning when you urinate.
Less serious side effects may include:
sneezing, runny or stuffy nose, sore throat, cough;
nausea, stomach pain, diarrhea; or
pain, swelling, redness, itching, bleeding, or other irritation where the medicine was injected;
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all other medications you use, especially:
a blood thinner such as warfarin (Coumadin);
cyclosporine (Gengraf, Neoral, Sandimmune);
digoxin (digitalis, Lanoxin, Lanoxicaps);
theophylline (Elixophyllin, Theo-24, Uniphyl);
seizure medication such as carbamazepine (Carbatrol, Tegretol), divalproex (Depakote), phenytoin (Dilantin), or valproic acid (Depakene); or
a heart rhythm medication such as disopyramide (Norpace), procainamide (Procan, Pronestyl), or quinidine (Quinidex, Quin-Release Quin-G).
This list is not complete and there may be other drugs that can interact with rilonacept. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.