Generic Name: salsalate (SAL sa late)Brand names: Disalcid, Salsitab, ...show all 8 brand names.Salflex, Argesic-SA, Amigesic, Marthritic, Mono-Gesic, Anaflex
Salsalate is a non-steroidal anti-inflammatory drug (NSAID) in a group of drugs called salicylates (sa-LIS-il-ates). This medicine works by reducing substances in the body that cause pain, fever, and inflammation.
Salsalate is used to reduce pain, swelling, and joint stiffness caused by arthritis.
Salsalate may also be used for other purposes not listed in this medication guide.
Before taking salsalate, tell your doctor if you have asthma, heart disease, high blood pressure, stomach or intestinal bleeding, diabetes, anemia, a bleeding disorder, liver or kidney disease, nasal polyps, a genetic enzyme deficiency, or if you are dehydrated.
Salsalate may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use salsalate just before or after heart bypass surgery (coronary artery bypass graft, or CABG).Get emergency medical help if you have chest pain, severe dizziness, shortness of breath, slurred speech, or problems with vision or balance.
This medicine may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking salsalate, especially in older adults.Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. This medication should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Salicylates can cause a serious and sometimes fatal condition called Reye's syndrome in children.
Salicylates may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use salsalate just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Salicylates may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning while you are taking salsalate, especially in older adults.You should not use this medication if you are allergic to aspirin or to an NSAID (non-steroidal anti-inflammatory drug).
If you have any of these other conditions, you may need a dose adjustment or special tests to safely take this medication:
heart disease, high blood pressure, congestive heart failure;
a history of stroke or heart attack;
a stomach ulcer or intestinal bleeding;
a bleeding or blood clotting disorder;
swelling or fluid retention;
anemia (a lack of red blood cells);
an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);
nasal polyps; or
if you are dehydrated.
Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.
Salsalate may be taken up to 3 times per day. Follow your doctor's instructions.Take the medicine with a full glass of water. Take salsalate with food, milk, or an antacid if it upsets your stomach. To prevent stomach upset, do not lie down for at least 30 minutes after taking salsalate. It may take up to 2 weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not start to improve after 2 weeks of treatment.
This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using salsalate.If you need to have any type of surgery, tell the surgeon ahead of time that you are using salsalate. You may need to stop using the medicine for a short time. Store salsalate at room temperature away from moisture and heat.
See also: Salsalate dosage in more detail
Since salsalate is often used as needed, you may not be on a dosing schedule. If you are using the medication regularly, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.
Overdose symptoms may include ringing in your ears, severe dizziness or drowsiness, sweating, fast breathing, severe vomiting or diarrhea, confusion, or seizure (convulsions).
If you are also taking low-dose aspirin because your doctor has prescribed it to prevent heart attack or stroke, do not stop taking it or change your dose without your doctor's advice. Aspirin should be used for cardiovascular conditions only under the supervision of a doctor.Avoid alcohol or use it in moderation while taking salsalate. If you drink more than three alcoholic beverages a day, the risk of stomach bleeding may increase. Avoid smoking while you are taking this medication. Smoking can also increase your risk of stomach bleeding.
chest pain, severe dizziness, shortness of breath, slurred speech, problems with vision or balance;
sudden numbness or weakness, especially on one side of the body;
feeling like you might pass out;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
hearing problems, ringing in your ears;
swelling in your hands or feet, rapid weight gain;
fast or pounding heartbeats;
easy bruising or bleeding, fever, chills, sore throat, flu symptoms;
urinating more or less than usual;
severe stomach pain, ongoing nausea or vomiting;
dark urine, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
upset stomach, heartburn; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Osteoarthritis:
1000 mg orally 3 times a day or 1500 mg orally twice a day.
Usual Adult Dose for Rheumatoid Arthritis:
1000 mg orally 3 times a day or 1500 mg orally twice a day.
Many drugs can interact with salsalate. Below is just a partial list. Tell your doctor if you are using:
cyclosporine (Gengraf, Neoral, Sandimmune);
lithium (Eskalith, LithoBid);
methotrexate (Rheumatrex, Trexall);
an antidepressant such as fluoxetine (Prozac) or sertraline (Zoloft);
a blood thinner such as warfarin (Coumadin);
diabetes medication you take by mouth;
a diuretic (water pill);
gout medication such as probenecid (Benemid);
heart or blood pressure medication such as atenolol (Tenormin), captopril (Capoten), lisinopril (Prinivil, Zestril), losartan (Cozaar, Hyzaar), metoprolol (Lopressor, Toprol), and others;
medication used to prevent blood clots, such as cilostazol (Pletal) or clopidogrel (Plavix);
medicine to treat or prevent osteoporosis, such as alendronate (Fosamax), ibandronate (Boniva), risedronate (Actonel), and others;
sodium bicarbonate, potassium citrate (K-Lyte, Urocit-K), sodium citrate and citric acid (Bicitra, Oracit), or sodium citrate and potassium (Citrolith, Polycitra);
seizure medication such as phenytoin (Dilantin), phenobarbital (Solfoton), valproic acid (Depakene); or
steroid medicine (prednisone and others).