Generic Name: mesoridazine (meh zoe RIH da zeen)Brand Names: Serentil
Mesoridazine is in a class of drugs called phenothiazines. It works by changing the actions of chemicals in your brain.
Mesoridazine is used to treat schizophrenia.
Mesoridazine may also be used for purposes other than those listed in this medication guide.What is the most important information I should know about Serentil (mesoridazine)?In rare cases, mesoridazine has caused serious irregular heartbeats, sometimes resulting in death. Do not take mesoridazine if you have any of the following conditions or a history of these conditions: heart disease; an irregular heartbeat or a history of irregular heartbeats; a history of prolonged QT intervals; a family history of congenital long QT syndrome; hypokalemia (low levels of potassium in your blood); slow heartbeats that require treatment; or other heartbeat disturbances. These conditions may increase the risk of irregular heartbeats, heart attack, and death while taking mesoridazine. Do not take mesoridazine with other drugs that can affect heartbeat rhythms such as quinidine (Cardioquin, Quinaglute, Quinidex, others), procainamide (Procan, Procanbid, Pronestyl), disopyramide (Norpace), and others. Taken with any of these drugs, mesoridazine (Serentil) may cause irregular heartbeats that could lead to death. This is not a complete list of drugs that may interact with mesoridazine and cause heart problems. Talk to your doctor or pharmacist before taking any other prescription or over-the-counter medications. Call your doctor immediately if you have uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs; fever; muscle rigidity; sweating; irregular pulse; or fast or irregular heartbeats. Use caution when driving, operating machinery, or performing other hazardous activities. Mesoridazine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.
Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.Mesoridazine may interact with other drugs that cause drowsiness, including alcohol, antidepressants, antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if mesoridazine is taken with alcohol or any of these medications. Talk to your doctor before taking mesoridazine in combination with alcohol or any other prescription or over-the-counter medicines. Do not mix the liquid form of this medication with coffee, cola, or tea.
Before taking this medication, tell your doctor if you have
a bone marrow disease,
an enlarged prostate or difficulty urinating,
You may not be able to take mesoridazine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.It is not known whether mesoridazine will harm an unborn baby. Do not take mesoridazine without first talking to your doctor if you are pregnant. It is not known whether mesoridazine passes into breast milk. Do not take mesoridazine without first talking to your doctor if you are breast-feeding a baby. If you are over 60 years of age, you may be more likely to experience side effects from mesoridazine. You may require a lower dose of this medication.
Take mesoridazine exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.Take each dose with a full glass (8 ounces) of water. Mesoridazine can be taken with or without food or milk.
Mix the concentrate with 2 to 4 ounces of water, noncola soda, juice, milk, or semisolid food such as applesauce or pudding.Do not mix the liquid with coffee, tea, or cola.
Do not let the liquid touch your skin or clothes.Do not stop taking mesoridazine without first talking to your doctor. It may be several weeks before you begin to feel better, and you may require continuous treatment for quite some time.
Throw away any discolored liquid.Store mesoridazine at room temperature away from moisture and heat. Store the liquid in a light-resistant container.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication.
Symptoms of a mesoridazine overdose include uncontrollable movements, agitation, seizures, severe dizziness or fainting, coma, very deep sleep, irregular heartbeats, and high or low body temperature.
Dizziness may be more likely to occur when you rise from a sitting or lying position. Rise slowly to prevent dizziness and a possible fall.Mesoridazine may interact with other drugs that cause drowsiness, including alcohol, antidepressants, antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if mesoridazine is taken with alcohol or any of these medications. Talk to your doctor before taking mesoridazine in combination with alcohol or any other prescription or over-the-counter medicines. Avoid prolonged exposure to sunlight. Mesoridazine may increase the sensitivity of your skin to sunlight. Use a sunscreen and wear protective clothing when sun exposure is unavoidable.
an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
uncontrollable movements of the mouth, tongue, cheeks, jaw, arms, or legs;
muscle spasms of the face or neck;
fast or irregular heartbeats.
severe restlessness or tremor;
dizziness or fainting; or
Other, less serious side effects may be more likely to occur. Continue to take mesoridazine and talk to your doctor if you experience:
dry mouth or stuffy nose;
mild restlessness, drowsiness, or tremor;
difficult urination or dark urine;
decreased sex drive;
increased appetite; or
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
Drugs other than those listed here may also interact with mesoridazine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.
Mesoridazine is available with a prescription under the brand name Serentil. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.
Serentil 10 mg--round, red, film-coated tablets
Serentil 25 mg--round, red, film-coated tablets
Serentil 50 mg--round, red, film-coated tablets
Serentil 100 mg--round, red, film-coated tablets
Serentil Concentrate--25mg/mL in a dropper bottle