Generic Name: fondaparinux (fon DAP a rin ux)Brand Names: Arixtra
Fondaparinux prevents the formation of blood clots.
Fondaparinux is used to prevent blood clots. It is often used in people who have undergone certain types of surgery.
Fondaparinux may also be used for other purposes not listed in this medication guide.What is the most important information I should know about Arixtra (fondaparinux)?You should not use fondaparinux if you weigh less than 110 pounds (50 kilograms), or if you have severe kidney disease, active bleeding, a low level of platelets in your blood, or an infection of the lining of your heart (also called bacterial endocarditis).
Before using fondaparinux, tell your doctor about all your medical conditions, especially kidney disease, hemophilia, a bleeding stomach ulcer, eye problems caused by diabetes, high blood pressure, a history of stroke, and any recent surgeries.
This medication comes with patient instructions for safe and effective use. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes. Ask your doctor or pharmacist if you have any questions.Fondaparinux should not be injected into a muscle or a vein. If you undergo a spinal tap or any type of spinal anesthesia (such as an epidural), tell the doctor ahead of time that you are using fondaparinux. You may need to stop using the medicine for a short time before having such procedures. Call your doctor at once if you have a serious side effect such as easy bruising, bleeding that will not stop, urinating less than usual or not at all, black or bloody stools, coughing up blood, sudden numbness or weakness, confusion, or problems with speech, vision, or balance.What should I discuss with my healthcare provider before using Arixtra (fondaparinux)?You should not use fondaparinux if you weigh less than 110 pounds (50 kilograms), or if you have:
a low level of platelets in your blood; or
an infection of the lining of your heart (also called bacterial endocarditis).
If you have any of these other conditions, you may need a dose adjustment or special tests to safely use fondaparinux:
a bleeding or blood clotting disorder such as hemophilia;
a stomach ulcer or history of stomach bleeding;
eye problems caused by diabetes;
severe or uncontrolled high blood pressure;
a history of stroke;
if you have recently had brain or eye surgery; or
if you are allergic to latex rubber.
Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.
This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
Fondaparinux is given as an injection under the skin. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to inject your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.Fondaparinux should not be injected into a muscle or a vein.
Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.Do not use the medication if it has changed colors or has any particles in it. Call your doctor for a new prescription.
To be sure fondaparinux is helping your condition, your blood will need to be tested on a regular basis. Your kidney function may also need to be checked. Do not miss any scheduled appointments.If you undergo a spinal tap or any type of spinal anesthesia (such as an epidural), tell the doctor ahead of time that you are using fondaparinux. You may need to stop using the medicine for a short time before having such procedures. Store fondaparinux at room temperature away from moisture and heat.
Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.
Overdose can cause easy bruising or increased bleeding.
Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using fondaparinux.
pale skin, easy bruising, nosebleeds, bleeding gums, or any bleeding that will not stop;
drowsiness, confusion, mood changes, increased thirst, loss of appetite;
swelling, weight gain, feeling short of breath;
urinating less than usual or not at all;
weakness or fainting;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
sudden numbness, weakness, headache, confusion, or problems with speech, vision, or balance; or
low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling).
Less serious side effects may include:
nausea, vomiting, constipation;
sleep problems (insomnia);
mild skin rash;
minor bleeding, rash, or itching where the medicine was injected.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all other medications you use, especially:
aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others; or
other medication used to prevent blood clots, such as alteplase (Activase), clopidogrel (Plavix), dipyridamole (Persantine), ticlopidine (Ticlid), and urokinase (Abbokinase).
This list is not complete and there may be other drugs that can interact with fondaparinux. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.