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Drugs reference index «Arixtra»



Generic Name: Fondaparinux (fon-DAP-a-rin-ux)Brand Name: Arixtra

Tell your doctor you are using Arixtra before having any procedures involving spinal anesthesia (puncture). Using Arixtra before these types of procedures may cause major bruising or bleeding (epidural or spinal hematoma) inside your body or spinal cord, leading to possibly permanent paralysis.

Arixtra is used for:

Preventing the formation of harmful blood clots, especially after hip, knee, or abdominal surgery. Arixtra is also used with warfarin to treat blood clots in the leg or lungs. It may also be used for other conditions as determined by your doctor.

Arixtra is an anticoagulant. It works by inhibiting one of the steps necessary for the formation of blood clots, which helps prevent clots from developing or worsening.

Do NOT use Arixtra if:

  • you are allergic to any ingredient in Arixtra
  • you have severe kidney problems, a heart infection (eg, bacterial endocarditis), or severe bleeding problems, or you are actively bleeding
  • you weigh less than 110 pounds (50 kg) and are using Arixtra to treat a blood clot in the lungs or legs
  • you weigh less than 110 pounds (50 kg) and will be having hip or knee replacement surgery or abdominal surgery, or you have had a hip fracture

Contact your doctor or health care provider right away if any of these apply to you.

Before using Arixtra :

Some medical conditions may interact with Arixtra . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances (eg, latex)
  • if you have a history of blood or bleeding problems (eg, low platelets), bleeding in the brain or stroke, or ulcers, or if you have recently had brain, eye, or spine surgery
  • if you have uncontrolled high blood pressure, kidney problems, or eye problems caused by diabetes (eg, diabetic retinopathy), or if you weigh less than 110 pounds (50 kg)

Some MEDICINES MAY INTERACT with Arixtra . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Activated protein C (eg, drotecogin alfa), anticoagulants (eg, warfarin), direct factor Xa inhibitors (eg, rivaroxaban), direct thrombin inhibitors (eg, dabigatran), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen), platelet inhibitors (eg, clopidogrel), or salicylates (eg, aspirin) because they may increase the risk of bleeding

This may not be a complete list of all interactions that may occur. Ask your health care provider if Arixtra may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Arixtra :

Use Arixtra as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Arixtra is usually given as an injection at your doctors office, hospital, or clinic. If you will be using Arixtra at home, a health care provider will teach you how to use it. Be sure you understand how to use Arixtra . Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Arixtra if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Use the proper technique taught to you by your doctor. Inject deep under the skin, NOT into muscle.
  • Use a different injection site each day to prevent problems at the injection site (eg, hematomas).
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Arixtra , contact your doctor right away.

Ask your health care provider any questions you may have about how to use Arixtra .

Important safety information:

  • Arixtra may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Tell your doctor or dentist that you take Arixtra before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including complete blood cell counts, kidney function tests, and stool blood tests, may be performed while you use Arixtra . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Arixtra with caution in the ELDERLY; they may be more sensitive to its effects, especially bleeding.
  • Arixtra should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Arixtra while you are pregnant. It is not known if Arixtra is found in breast milk. If you are or will be breast-feeding while you use Arixtra , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Arixtra :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bleeding, irritation, rash, or itching at the injection site; chills; constipation; diarrhea; headache; minor bleeding; nausea; sleeplessness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; confusion; fever; one-sided weakness; persistent headache; slurred speech; swelling of the ankles, feet, or hands; unusual dizziness, tiredness, or weakness; unusual or severe bleeding or bruising; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include excessive bleeding and bruising.

Proper storage of Arixtra :

Store Arixtra at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Arixtra out of the reach of children and away from pets.

General information:

  • If you have any questions about Arixtra , please talk with your doctor, pharmacist, or other health care provider.
  • Arixtra is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Arixtra . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Arixtra Prescribing Information (FDA)
  • Arixtra Concise Consumer Information (Cerner Multum)
  • Arixtra Advanced Consumer (Micromedex) - Includes Dosage Information

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