Pronunciation: (SILL-ver SULL-fah-DIE-ah-zeen)Class: Burn preparation
Trade Names:Silvadene- Cream 10 mg/g in a water-miscible base
Trade Names:SSD- Cream 10 mg/g in a water-miscible base
Trade Names:SSD AF- Cream 10 mg/g in a water-miscible base
Trade Names:Thermazene- Cream 10 mg/g in a water-miscible baseFlamazine
Inhibits bacteria by acting on cell membrane and cell wall.
Indications and Usage
Adjunct for prevention and treatment of wound sepsis in patients with second- and third-degree burns.
Pregnancy in women approaching term; premature infants; infants during first 2 mo of life; hypersensitivity to any component of product.
Dosage and AdministrationAdults
Topical Clean and debride wound and apply cream under sterile conditions. Cover burn areas with cream at all times, applying 1 to 2 times daily to a thickness of about 1/ 16 inch. Reapply cream whenever necessary to any areas from which it has been removed by patient activity. Reapply immediately after hydrotherapy and continue until satisfactory healing has occurred or until burn site is ready for grafting.
Store cream at controlled room temperature (59° to 86°F).
None well documented.
Laboratory Test Interactions
None well documented.
Skin necrosis; erythema multiforme; skin discoloration; burning sensation; rashes; allergic reactions (including Stevens-Johnson syndrome, exfoliative dermatitis).
Interstitial nephritis; toxic nephrosis.
Hepatitis; hepatocellular necrosis.
Transient leukopenia characterized by decreased neutrophil count; blood dyscrasias (including agranulocytosis, aplastic anemia, thrombocytopenia, and hemolytic anemia).
Category B .
Safety and efficacy not established.
Potential cross-sensitivity with other sulfonamides may occur.
May occur in and below eschar.
Hepatic/Renal function impairment
Elimination of drug may become decreased, resulting in accumulation.
- Advise patient or caregiver that cream is used to prevent infections in burn wounds in hospitalized and nonhospitalized patients.
- Teach patient or caregiver using cream at home proper technique for applying cream: Wash hands. Using sterile gloves, apply sufficient cream ( 1/ 16 inch thickness) to cover affected areas. Wash hands after applying cream.
- Advise patient or caregiver to apply cream twice daily as directed by health care provider.
- Advise patient or caregiver to keep burned areas covered with cream at all times and to reapply cream whenever necessary to any area from which it has been removed by patient activity, bathing, or hydrotherapy.
- Caution patient or caregiver not to bandage, cover, or wrap treated skin areas, or use other skin products over treated areas, unless advised by health care provider.
- Caution patient to avoid contact with eyes. Advise patient that if medication does come into contact with the eyes to wash them with large amounts of cool water and to contact health care provider if eye irritation occurs.
- Advise patient to report application-site reactions (eg, rash, burning, stinging, itching).
Copyright © 2009 Wolters Kluwer Health.
- Silvadene Prescribing Information (FDA)
- Silvadene MedFacts Consumer Leaflet (Wolters Kluwer)
- Silvadene Concise Consumer Information (Cerner Multum)
- Silvadene Topical Advanced Consumer (Micromedex) - Includes Dosage Information
- Thermazene Prescribing Information (FDA)