Generic name: simvastatin and niacinBrand names: Simcor
Simcor is a combination of simvastatin and niacin and is indicated in the treatment of hypercholesterolemia (increased cholesterol) in patients at increased risk of atherosclerotic vascular disease (eg, Coronary artery disease).
Simcor should not be substituted for immediate-release niacin. If you are switching from immediate-release niacin to Simcor, dosage should start at 500/20 mg. Doses of Simcor greater than 2000/40 mg are not recommended. Simcor may cause skeletal muscle effects, liver enzyme abnormalities, and glucose level abnormalities.
Do not take Simcor if you have active liver disease, have a peptic ulcer, have arterial bleed, are pregnant or may become pregnant or are breastfeeding, or have a known hypersensitivity to any component of this product.
Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Simcor. Also, talk to your doctor about your complete medical history.
The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.
Adults: The maximum recommended dose is 2000/40 mg.
Simcor tablets should be taken at bedtime, after a low-fat snack. Do not crush or chew the tablet. It should be swallowed whole.
Do not take Simcor on an empty stomach. Do not crush or chew the tablet. Avoid ingestion of alcohol, hot beverages, and spicy food when taking Simcor to minimize flushing.
If Simcor is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Simcor with the following: Itraconazole, ketoconazole and other antifungal azoles, macrolide antibiotics (erythromycin, clarithromycin, telithromycin), HIV protease inhibitors, nefazodone (antidepressant), cyclosporine, danazol, gemfibrozil, verapamil, amiodarone, other fibrates.
Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Simcor.
Simcor is to be avoided if you are pregnant or breastfeeding.
Store at room temperature.