Generic Name: aspirin and dipyridamole (AS pi rin and dye peer ID a mole)Brand Names: Aggrenox
Aspirin is in a group of drugs called salicylates (sa-LIS-il-ates). It works by reducing substances in the body that cause pain, fever, and inflammation.
Dipyridamole keeps platelets in your blood from sticking together to form clots.
The combination of aspirin and dipyridamole is used to reduce the risk of stroke in people who have had blood clots or a "mini-stroke" (also called a transient ischemic attack or TIA).
Aspirin and dipyridamole may also be used for other purposes not listed in this medication guide.What is the most important information I should know about aspirin and dipyridamole?Do not use this medication without telling your doctor if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment. Do not use any other over-the-counter pain medication without first asking your doctor or pharmacist. Aspirin, salicylates, and NSAIDs (non-steroidal anti-inflammatory drugs) are contained in many medicines available over the counter. If you take certain products together you may accidentally take too much of a certain type of drug. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, naproxen, ketoprofen, magnesium and/or choline salicylate. Aspirin should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Aspirin can cause a serious and sometimes fatal condition called Reye's syndrome in children.
Stop using this medication and call your doctor at once if you have any symptoms of bleeding in your stomach or intestines. Symptoms include weakness or fainting, black, bloody, or tarry stools, and coughing up blood or vomit that looks like coffee grounds.Avoid drinking alcohol while you are taking aspirin and dipyridamole. Alcohol may increase your risk of stomach bleeding. If you drink more than three alcoholic beverages per day, do not take aspirin and dipyridamole without your doctor's advice.What should I discuss with my healthcare provider before taking aspirin and dipyridamole?Aspirin should not be given to a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Aspirin can cause a serious and sometimes fatal condition called Reye's syndrome in children. Do not use this medication if you are allergic to aspirin or dipyridamole (Persantine), or if you have:
nasal polyps; or
a history of allergy to an NSAID (non-steroidal anti-inflammatory drug) such as Advil, Motrin, Aleve, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others.
Before taking aspirin and dipyridamole, tell your doctor if you are allergic to any drugs, or if you have:
a history of stomach ulcers or bleeding;
a bleeding disorder such as hemophilia;
heart disease, congestive heart failure, or recent heart attack;
low blood pressure.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use aspirin and dipyridamole without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. Aspirin and dipyridamole can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.Take each dose with a full glass (8 ounces) of water.
You may take aspirin and dipyridamole with or without food.Do not crush, chew, break, or open an extended-release capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time.
Taking the combination of aspirin and dipyridamole (Aggrenox) is not equivalent to taking each of the medications separately. Take only the medication your doctor has prescribed.
If you need to have any type of surgery, tell the surgeon ahead of time that you are taking aspirin. You may need to stop using the medicine for a short time.Store aspirin and dipyridamole at room temperature away from moisture and heat.
See also: Aspirin and dipyridamole dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.
weakness or fainting;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
severe nausea, vomiting, or stomach pain;
fever lasting longer than 3 days;
swelling, or pain lasting longer than 10 days; or
hearing problems, ringing in your ears.
Less serious side effects may include:
upset stomach, mild heartburn, nausea, vomiting, diarrhea;
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Ischemic Stroke -- Prophylaxis:
1 capsule (25 mg aspirin/200 mg extended-release dipyridamole) orally, twice a day; 1 in the morning and 1 in the evening.
Before taking aspirin and dipyridamole, tell your doctor if you are using any of the following drugs:
methotrexate (Rheumatrex, Trexall);
diabetes medications that you take by mouth;
gout medications such as probenecid (Benemid) or sulfinpyrazone (Anturane);
an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), quinapril (Accupril), ramipril (Altace), and others;
Alzheimer medications such as donepezil (Aricept), galantamine (Reminyl), or rivastigmine (Exelon);
a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), esmolol (Brevibloc), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), sotalol (Betapace), timolol (Blocadren), and others;
a diuretic (water pill) such as amiloride (Midamor, Moduretic), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Hyzaar, Lopressor, Vasoretic, Zestoretic), spironolactone (Aldactazide, Aldactone), triamterene (Dyrenium, Maxzide, Dyazide), and others;
seizure medication such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), or phenobarbital (Luminal, Solfoton); or
aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), indomethacin (Indocin), ketoprofen (Orudis), meloxicam (Mobic), nabumetone (Relafen), piroxicam (Feldene), and others.
This list is not complete and there may be other drugs that can interact with aspirin and dipyridamole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.