Generic Name: conivaptan (koe NYE vap tan)Brand Names: Vaprisol
Conivaptan reduces the level of a hormone that regulates the balance of water and salt (sodium) in the body. High levels of this hormone can cause an imbalance that results in low sodium levels and fluid retention.
Conivaptan is used to treat hyponatremia (low sodium levels). Conivaptan improves urine flow without causing the body to lose too much sodium as you urinate.
Conivaptan may also be used for purposes other than those listed in this medication guide.
Before receiving conivaptan, tell your doctor if you have congestive heart failure, kidney disease, or liver disease.Do not receive conivaptan if you are also using any of these medications: ketoconazole (Nizoral), itraconazole (Sporanox), clarithromycin (Biaxin), ritonavir (Norvir), or indinavir (Crixivan).
Conivaptan is usually given only in a hospital. The medicine is given through an IV line and treatment is continued around-the-clock for up to 4 days.
Because conivaptan can irritate the skin or vein when the medicine enters the body, your IV needle will be moved to a different vein every 24 hours.While receiving conivaptan, tell your doctor at once if you have pain, redness, or swelling where the IV needle is placed.
ritonavir (Norvir); or
Before you receive this conivaptan, tell your doctor if you are allergic to any drugs, or if you have:
congestive heart failure;
liver disease; or
If you have any of the conditions listed above, you may not be able to receive conivaptan or you may need a dosage adjustment or special tests during treatment.Conivaptan is in the FDA pregnancy category C. This means that it is not known if it will be harmful to an unborn baby. Do not receive this medication without telling your doctor if you are pregnant. Tell your doctor if you become pregnant during treatment. It is not known if conivaptan passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.
Conivaptan is given as an injection (infusion) into a vein. Your doctor, nurse, or pharmacist will give you the medicine through an IV line and a needle placed into one of your large veins (such as in your upper chest).
Conivaptan is infused around-the-clock for up to 4 days. This medication is usually given only in a hospital.
Because conivaptan can irritate the skin or vein when the medicine enters the body, your IV needle will be moved to a different vein every 24 hours.
It is unlikely that you will miss a dose of this medication since it is usually given while you are in a hospital.
Symptoms of an overdose may include light-headedness, fainting, or extreme thirst.
Avoid drinking more fluids than your doctor recommends while you are receiving treatment with conivaptan.
Tell your doctor or nurse if you have any of these other serious side effects:
pain, redness, or swelling where the IV needle is placed;
confusion, extreme thirst;
feeling light-headed, fainting;
swelling, rapid weight gain; or
pain or burning when you urinate.
Less serious side effects may be more likely to occur. Talk with your doctor or nurse if you have any of these side effects:
headache, sleep problems (insomnia);
painful white patches in your mouth or throat; or
mild thirst and increased urination.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
There may be other drugs that can affect conivaptan. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.