Generic Name: auranofin (aw RAN oh fin)Brand Names: Ridaura
Auranofin is a form of gold that reduces some of the effects of the inflammatory process in the body.
Auranofin is used to treat rheumatoid arthritis.
Auranofin is usually given when other medications have been tried without successful treatment of symptoms.Auranofin will not reverse any cartilage or joint damage that has already occurred in your body.
Auranofin may also be used for other purposes not listed in this medication guide.
Before taking auranofin, tell your doctor if you have a weak immune system, bone marrow disorder, kidney or liver disease, or inflammatory bowel disease.
Auranofin can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis.Keep using auranofin as directed. Talk with your doctor if your symptoms do not improve after 3 or 4 months of treatment. Stop taking auranofin and call your doctor at once if you have a skin rash or itching, mouth sores, severe diarrhea, easy bruising or bleeding, blood in your urine or stools, coughing up blood, or unusual weakness, or any signs of infection (fever, chills, flu symptoms).
an allergic skin reaction;
stomach or intestinal problems;
a breathing disorder;
a bone marrow disorder; or
a severe blood cell disorder.
If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:
a bone marrow disorder or weak immune system;
inflammatory bowel disease.
Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results from this medication.Take this medicine with a full glass of water.
Auranofin can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Do not miss any scheduled appointments.
Contact your doctor at once if you develop signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, or unusual weakness.It may take up to 6 months of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 3 or 4 months of treatment. Store auranofin at room temperature away from moisture, heat, and light.
See also: Auranofin dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
Symptoms of an auranofin overdose are not known.
Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.Avoid exposure to sunlight, sunlamps, or tanning beds. Auranofin can make your skin more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use sunscreen (SPF 15 or higher) when you are outdoors.
itching or skin rash;
white patches or sores inside your mouth or on your lips;
pain or swelling in your gums or tongue, metallic taste in your mouth;
severe or ongoing diarrhea;
severe nausea, vomiting, stomach cramps;
pale skin, easy bruising or bleeding;
blood in your urine;
weakness or fainting;
black, bloody, or tarry stools; or
coughing up blood or vomit that looks like coffee grounds.
Less serious side effects may include:
mild stomach pain or upset;
gas, bloating; or
loss of appetite.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Rheumatoid Arthritis:
Initial: 3 mg orally once a day for 2 weeks. The goal of therapy is to gradually taper up to a dose of 6 mg orally each day with limited diarrhea.Maintenance: 6 mg orally each day administered either as a single dose or as 3 mg orally twice a day to decrease the incidence of gastrointestinal side effects. A therapeutic response to auranofin may not be clinically apparent for 3 to 6 months after initiation of therapy. If, after this time, the response is considered inadequate the dosage may be increased to a maximum of 3 mg orally 3 times a day. If the response remains inadequate after 2 to 3 months at 9 mg/day, an alternative therapy should be considered.
Usual Pediatric Dose for Rheumatoid Arthritis:
>1 to 12 years:Initial: 0.1 mg/kg/day in 1 to 2 equally divided doses.>1 to 12 years: Maintenance: 0.15 mg/kg/day in 1 to 2 equally divided doses, with a maximum dose of 0.2 mg/kg/day administered in a single dose or equally divided doses 12 hours apart.
Tell your doctor about all other medications you use, especially:
penicillamine (Cuprimine, Depen);
high doses of steroid medication (prednisone and others); or
drugs that weaken your immune system, such as cyclophosphamide (Cytoxan, Neosar), azathioprine, methotrexate (Rheumatrex, Trexall), and others.
This list is not complete and there may be other drugs that can interact with auranofin. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.