Generic Name: voriconazole (vor i KON a zole)Brand Names: VFEND
Voriconazole is an antifungal medication.
Voriconazole is used to treat infections caused by yeast or other types of fungus.
Voriconazole may also be used for other purposes not listed in this medication guide.
There are many other medicines that can cause serious or life-threatening drug interactions with voriconazole. Tell your doctor about all the prescription and over-the-counter medications you use.
Before taking voriconazole, tell your doctor if you have heart rhythm problems, an electrolyte imbalance, liver or kidney disease, or a history of allergy to other antifungal medications such as fluconazole (Diflucan), ketoconazole (Nizoral), or itraconazole (Sporanox).Use voriconazole for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated.
Voriconazole can cause problems with your vision. If you use this medicine for more than 28 days, you may need to have your eyes checked.
quinidine (Cardioquin, Quinora, Quinidex, Quinaglute, Quin-Release, Quin-G);
rifabutin (Mycobutin) or rifampin (Rifadin, Rimactane, Rifater);
an ergot medicine such as ergotamine (Ergomar, Cafergot, Ercaf, Wigraine, others) or dihydroergotamine (D.H.E., Migranal); or
(these drugs are no longer available in the U.S.) terfenadine (Seldane) or astemizole (Hismanal).
The drugs listed above can cause dangerous serious or life-threatening drug interactions with voriconazole. Tell your doctor about all other medicines you are using.
If you have any of these other conditions, you may need a dose adjustment or special tests to safely use voriconazole:
heart rhythm problems;
a metabolic disorder such as high or low levels of calcium, potassium, or magnesium;
a history of allergy to other antifungal medications such as fluconazole (Diflucan), ketoconazole (Nizoral), or itraconazole (Sporanox).
Voriconazole tablets contain lactose. Before taking a voriconazole tablet, tell your doctor if you have a hereditary form of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption.FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use voriconazole without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using voriconazole. It is not known if voriconazole passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.Take voriconazole at least one hour before or after eating a meal. Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Do not mix the oral suspension with any other medicine or liquid. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated.
To be sure voriconazole is helping your condition, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Visit your doctor regularly.
Voriconazole can cause problems with your vision. If you use this medicine for more than 28 days, you may need to have your eyes checked.Store voriconazole tablets at room temperature away from moisture and heat. Store the oral liquid at room temperature for up to 14 days. Throw away any unused liquid after 14 days.
See also: VFEND dosage in more detail
Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.
Overdose symptoms may include vision problems, excessive mouth watering, enlarged pupils, weakness, loss of balance, shortness of breath, or seizure (convulsions).
sudden behavior changes, problems with thinking or speech;
stomach pain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes);
urinating less than usual or not at all;
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
uneven heart rate, chest pain, general ill feeling.
Less serious side effects may include:
vision problems such as blurred vision, eyes being more sensitive to light;
mild nausea, vomiting, or diarrhea;
swelling in your hands, ankles, or feet.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Many drugs can interact with voriconazole. Below is just a partial list. Tell your doctor if you are using:
cyclosporine (Sandimmune, Neoral);
stomach acid reducers such as esomeprazole (Nexium), omeprazole (Prilosec), lansoprazole (Prevacid), or pantoprazole (Protonix);
tranquilizers or sedatives such as alprazolam (Xanax), diazepam (Valium), midazolam (Versed), triazolam (Halcion), and others;
cholesterol-lowering medicines such as atorvastatin (Lipitor), lovastatin (Mevacor), pravastatin (Pravachol), or simvastatin (Zocor);
vinblastine (Velban), vincristine (Oncovin), or vinorelbine (Navelbine);
a calcium channel blocker such as verapamil (Isoptin, Verelan, Calan, Covera), amlodipine (Norvasc), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), or nisoldipine (Sular); or
an oral diabetes medicine such as glipizide (Glucotrol), glyburide (DiaBeta, Micronase), tolbutamide (Orinase), tolazamide (Tolinase), or chlorpropamide (Diabinese).
This list is not complete and there may be other drugs that can interact with voriconazole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.