Avastin Solution may cause severe stomach or bowel problems (eg, abscess, fistula, perforation). These effects are not common, but are serious and sometimes may be fatal. Contact your doctor immediately if you develop unusual stomach pain along with constipation, fever, nausea, or vomiting.
Avastin Solution may cause serious and sometimes fatal wound healing problems. Tell your doctor immediately if you notice any wounds that do not heal. Tell your doctor if you have had surgery within the past 28 days. If possible, Avastin Solution should be stopped at least 28 days before surgery and until the surgical wound heals.
Avastin Solution may cause severe and sometimes fatal bleeding. This may occur in the lungs, stomach or intestines, or brain. Nosebleed or vaginal bleeding may also occur. Patients who have current severe bleeding or a recent history of coughing up blood should not use Avastin Solution. Contact your doctor right away if you experience unusual bleeding or bruising.
Treating certain types of advanced lung cancer. It is also used to treat certain types of brain, breast, kidney, colon, or rectal cancer. It is used with other cancer medicines.
Avastin Solution is a monoclonal antibody. It works by decreasing the formation and growth of new blood vessels in the tumor by blocking the action of a protein called vascular endothelial growth factor (VEGF). This helps to slow the growth and spread of cancer.
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Avastin Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
Some MEDICINES MAY INTERACT with Avastin Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:
This may not be a complete list of all interactions that may occur. Ask your health care provider if Avastin Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
Use Avastin Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Ask your health care provider any questions you may have about how to use Avastin Solution.
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Changes in taste; constipation; diarrhea; dizziness; dry mouth; dry skin; hair loss; headache; increased thirst; indigestion; loss of appetite; minor nosebleeds; mouth pain or sores; muscle pain; nausea; pain, swelling, or redness at the injection site; sluggishness; stuffy or runny nose; tiredness; voice changes; vomiting; weakness; weight loss.Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in the urine; calf pain or tenderness; chest pain; confusion; cough; coughing or choking while eating; coughing up or vomiting blood; dark urine; difficult or painful urination; fainting; fever, chills, or persistent sore throat; frequent or urgent urination; loss of coordination; numbness of the arms or legs; one-sided weakness; peeling of skin; seizure; severe or persistent headache; severe or persistent nosebleed; severe or persistent stomach pain, constipation, nausea, or vomiting; severe or persistent weakness; shortness of breath; skin discoloration, irritation, or lesions; speech changes; sudden, severe dizziness; swelling, discoloration, or pain in the legs; swelling of the hands, ankles, or feet; trouble swallowing; unusual bruising or bleeding; unusual or severe sweating; unusual weight gain; vaginal pain, bleeding, or discharge; vision loss, blurred vision, or other vision changes; wheezing; wounds that do not heal.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include severe headache.Proper storage of Avastin Solution:
Avastin Solution is usually handled and stored by a health care provider. If you are using Avastin Solution at home, store Avastin Solution as directed by your pharmacist or health care provider.
This information is a summary only. It does not contain all information about Avastin Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.