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Drugs reference index «Zofran ODT»

Zofran ODT

Generic Name: ondansetron (Oral route, Injection route, Intravenous route)

on-DAN-se-tron

Commonly used brand name(s):

In the U.S.

  • Zofran
  • Zofran ODT

Available Dosage Forms:

  • Tablet, Disintegrating
  • Solution
  • Tablet

Therapeutic Class: Antiemetic

Pharmacologic Class: Serotonin Receptor Antagonist, 5-HT3

Uses For Zofran ODT

Ondansetron is used to prevent the nausea and vomiting that may occur after therapy with anticancer medicines (chemotherapy) or radiation, or after surgery.

Ondansetron is available only with your doctor's prescription.

Before Using Zofran ODT

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

This medicine has been tested in a limited number of children with cancer 6 months of age or older and after surgery in children 1 month to 12 years of age. In effective doses, the medicine has not been shown to cause different side effects or problems than it does in adults.

Geriatric

This medicine has been tested in a limited number of cancer patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Apomorphine
  • Mesoridazine
  • Pimozide
  • Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Amiodarone
  • Arsenic Trioxide
  • Azimilide
  • Bretylium
  • Dofetilide
  • Droperidol
  • Enflurane
  • Halothane
  • Ibutilide
  • Isoflurane
  • Isradipine
  • Sematilide
  • Sotalol
  • Tedisamil
  • Telithromycin

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cyclophosphamide

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Abdominal surgery—Use of ondansetron may cover up stomach problems
  • Allergy to selective 5-HT3 receptor antagonists (alosetron [e.g., Lotronex], dolasetron [e.g., Anzemet], granisetron [e.g., Kytril], palonosetron [e.g., Aloxi])— If you are allergic to one of these, you may be allergic to ondansetron because they are in the same group of medicines.
  • Liver disease—Patients with liver disease may have an increased chance of side effects
  • Phenylketonuria (PKU)—The oral disintegrating tablets may contain aspartame, which can make your condition worse.

Proper Use of ondansetron

This section provides information on the proper use of a number of products that contain ondansetron. It may not be specific to Zofran ODT. Please read with care.

If you vomit within 30 minutes after taking this medicine, take the same amount of medicine again. If vomiting continues, check with your doctor.

For patients using the oral disintegrating tablet form of this medicine:

  • Make sure your hands are dry.
  • Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet.
  • Immediately place the tablet on top of the tongue.
  • The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquid to swallow the tablet.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (solution, oral disintegrating tablets, and tablets):
    • For prevention of moderate nausea and vomiting after anticancer medicine:
      • Adults and children 12 years of age and older—At first, the dose is 8 milligrams (mg) taken thirty minutes before the anticancer medicine is given. The 8-mg dose is taken again eight hours after the first dose. Then, the dose is 8 mg every twelve hours for one to two days.
      • Children 4 to 11 years of age—At first, the dose is 4 mg taken thirty minutes before the anticancer medicine is given. The 4-mg dose is taken again four and eight hours after the first dose. Then, the dose is 4 mg every eight hours for one to two days.
      • Children up to 4 years of age—Dose must be determined by your doctor.
    • For prevention of more severe nausea and vomiting after anticancer medicine:
      • Adults and children 12 years of age and older—One 24-milligram (mg) tablet taken thirty minutes before the anticancer medicine is given.
      • Children up to 12 years of age—Use and dose must be determined by your doctor.
    • For prevention of nausea and vomiting after surgery:
      • Adults—Dose is usually 16 mg one hour before anesthesia (medicine to put you to sleep before surgery).
      • Children—Dose must be determined by your doctor.
    • For prevention of nausea and vomiting after radiation treatment:
      • Adults—At first, the dose is 8 mg taken one to two hours before radiation treatment. Then, the dose is 8 mg every eight hours.
      • Children—Dose must be determined by your doctor.
  • For injection dosage form:
    • For prevention of nausea and vomiting after anticancer medicine:
      • Adults—Dose is usually 32 mg injected into a vein, over a period of fifteen minutes, beginning thirty minutes before the anticancer medicine is given. Or, if the dose is based on body weight, it is usually 150 micrograms (mcg) per kilogram (kg) (68 mcg per pound) of body weight. This dose is injected into a vein over a period of fifteen minutes, beginning thirty minutes before the anticancer medicine is given. It is injected again four and eight hours after the first dose.
      • Children 6 months to 18 years of age—Dose is based on body weight and must be determined by your doctor. It is usually 150 mcg per kg (68 mcg per pound) of body weight, injected into a vein over a period of fifteen minutes, beginning thirty minutes before the anticancer medicine is given. The dose is given again four and eight hours after the first dose.
      • Children up to 6 months of age—Dose must be determined by your doctor.
    • For prevention of nausea and vomiting after surgery:
      • Adults—Dose is usually 4 mg injected into a vein over a period of thirty seconds to five minutes. It is given just before anesthesia (medicine to put you to sleep before surgery) or right after surgery if nausea and vomiting begin.
      • Children 1 month to 12 years of age—Dose is based on body weight and must be determined by your doctor. It is usually 100 mcg per kg (45.5 mcg per pound) of body weight for children weighing 40 kg or less (88 pounds or less), or 4 mg for children weighing over 40 kg (over 88 pounds). The dose is injected into a vein over a period of thirty seconds to five minutes. It is given just before anesthesia or after surgery if nausea and vomiting begin.
      • Children up to 1 month of age—Dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you miss a dose of this medicine, and you feel nauseated or you vomit, take the missed dose as soon as possible.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Zofran ODT Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare
  • Chest pain or discomfort
  • pain, redness, or burning at place of injection
  • shortness of breath
  • skin rash, hives, redness, and/or itching
  • tightness in chest
  • troubled breathing
  • wheezing
Incidence not known
  • Blurred vision
  • cold, clammy skin
  • confusion
  • coughing
  • decreased or irregular heartbeat
  • difficulty in breathing or swallowing
  • dizziness or fainting
  • dizziness, faintness, or lightheadedness when getting up from a lying position
  • fast, pounding, slow, or irregular heartbeat or pulse
  • fast, weak pulse
  • fixed position of eye
  • heart stops
  • hives or welts
  • hoarseness
  • inability to move eyes
  • increased blinking or spasms of eyelid
  • lab results that show problems with liver
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs
  • lightheadedness
  • no breathing
  • no pulse or blood pressure
  • noisy breathing
  • pain in neck, back, or jaw
  • palpitations
  • shortness of breath
  • slow or irregular breathing
  • sticking out of tongue
  • sweating
  • swelling of face, throat, or tongue
  • trouble in breathing, speaking, or swallowing
  • unconscious
  • uncontrolled twisting movements of neck, trunk, arms, or legs
  • unusual facial expressions
  • weakness
  • weakness of arms and legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Constipation
  • diarrhea
  • fever
  • headache
Less common
  • Abdominal pain or stomach cramps
  • burning, tingling, or prickling sensations
  • dizziness or lightheadedness
  • drowsiness
  • dryness of mouth
  • feeling cold
  • itching
  • unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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  • Zofran ODT Prescribing Information (FDA)
  • Zofran ODT Orally Disintegrating Tablets MedFacts Consumer Leaflet (Wolters Kluwer)
  • Zofran ODT Detailed Consumer Information (PDR)
  • Ondansetron MedFacts Consumer Leaflet (Wolters Kluwer)
  • Ondansetron Prescribing Information (FDA)
  • Zofran Consumer Overview
  • Zofran Prescribing Information (FDA)

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