Generic Name: goserelin (GOE se REL in)Brand Names: Zoladex
Goserelin is a man-made form of a hormone that regulates many processes in the body. Goserelin overstimulates the body's own production of certain hormones, which causes that production to shut down temporarily.
Goserelin is used in men to treat symptoms of prostate cancer, and in women to treat breast cancer or endometriosis. Goserelin is also used in women to prepare the lining of the uterus for endometrial ablation (a surgery to correct abnormal uterine bleeding).
If you are receiving goserelin to treat prostate cancer, use any other medications your doctor has prescribed to best treat your condition. Goserelin treats only the symptoms of prostate cancer but does not treat the cancer itself.
Goserelin may also be used for other purposes not listed in this medication guide.
Before you receive goserelin, tell your doctor if you have osteoporosis, diabetes, urination problems, a condition affecting your spine, or if you have abnormal bleeding that your doctor has not checked.Goserelin can decrease bone mineral density, which may increase your risk of developing osteoporosis. This risk may be greater if you smoke, drink alcohol frequently, have a family history of osteoporosis, or use certain drugs such as seizure medications or steroids. Talk to your doctor about your individual risk of bone loss. Call your doctor at once if you have a serious side effect such as severe numbness or tingling in your legs or feet, muscle weakness, problems with balance or coordination, loss of bladder or bowel control, urinating more or less than usual, pain or burning when you urinate, feeling like you might pass out, pale skin, easy bruising, trouble breathing, chest pain or heavy feeling, or changes in heart rate.
If you are using goserelin to treat prostate cancer, use any other medications your doctor has prescribed to best treat your condition. Goserelin treats only the symptoms of prostate cancer but does not treat the cancer itself.
If you have any of these other conditions, you may need a dose adjustment or special tests to safely use goserelin:
osteoporosis or low bone density;
painful or difficult urination;
a condition affecting your spine; or
if you have abnormal bleeding that your doctor has not checked.
Goserelin is given in a tiny implant that is inserted through a needle injected under the skin of your upper stomach. You will receive this injection in a clinic or doctor's office.
You are not likely to be able to feel the implant through your skin, and it should not cause pain or discomfort. The implant will dissolve in your body over time.
A new goserelin implant is usually injected every 28 days, but the timing of your dose may be different if you are also receiving chemotherapy. Follow your doctor's instructions. It is very important to receive your goserelin injections on time each month.If you are a premenopausal woman, you should stop having menstrual periods during treatment with goserelin. Call your doctor if you still have regular periods. Missing a dose can cause breakthrough bleeding.
While your homone levels are adjusting to goserelin, you may notice increased symptoms or new symptoms of your condition. This should be only temporary during the first few weeks of treatment. Tell your doctor if your symptoms do not improve after several weeks of using goserelin.
Your blood sugar may need to be checked while using goserelin, even if you are not diabetic. You may also need other blood tests at your doctor's office. Do not miss any appointments.
This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using goserelin.
It is important not to miss a dose of goserelin. Contact your doctor immediately if you miss a dose of this medication.
Since the goserelin implant contains a specific amount of the medication, you are not likely to receive an overdose.
back pain, severe numbness or tingling in your legs or feet;
muscle weakness, problems with balance or coordination;
loss of bladder or bowel control;
urinating less than usual or not at all;
pain or burning when you urinate;
feeling like you might pass out;
pale skin, easy bruising;
chest pain or heavy feeling, changes in heart rate; or
nausea, loss of appetite, increased thirst, muscle weakness, confusion, and feeling tired or restless.
Less serious side effects may include:
hot flashes, sweating, headache, dizziness;
mood changes, vaginal dryness, increased or decreased interest in sex;
impotence, fewer erections than normal;
breast swelling or tenderness;
nausea, vomiting, diarrhea, constipation;
loss of appetite, nausea, or diarrhea;
sleep problems (insomnia); or
acne, mild skin rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
There may be other drugs that can interact with goserelin. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.