Generic Name: aztreonam (AZ tree oh nam)Brand Names: Azactam
Aztreonam is an antibiotic that fights severe or life-threatening infection caused by bacteria.
Aztreonam is used to treat severe infections of the urinary tract, lower respiratory tract, skin, stomach, female reproductive organs, and other body systems.
Aztreonam may also be used for purposes other than those listed in this medication guide.
Before using aztreonam, tell your doctor if you are allergic to cephalosporins such as Ceclor, Ceftin, Duricef, Keflex, and others, or if you have liver or kidney disease, or a history of any type of allergy.Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Aztreonam will not treat a viral infection such as the common cold or flu.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.What should I discuss with my health care provider before using Azactam (aztreonam)?You should not use this medication if you are allergic to aztreonam or to a penicillin antibiotic, such as:
amoxicillin (Amoxil, Amoxicot, Biomox, Dispermox, Trimox);
ampicillin (Omnipen, Principen);
dicloxacillin (Dycill, Dynapen);
oxacillin (Bactocill); or
penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids, and others).
Also tell your doctor if you are allergic to any other drugs, especially:
cephalosporins such as cefaclor (Ceclor), Ceftin (cefuroxime), cefadroxil (Duricef), cephalexin (Keflex), and others; or
similar antibiotics such as ertapenem (Invanz), imipenem (Primaxin), or meropenem (Merrem).
Before using aztreonam, tell your doctor if you have:
kidney disease; or
a history of any type of allergy.
If you have any of these conditions, you may not be able to use aztreonam, or you may need a dosage adjustment or special tests during treatment.FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Aztreonam can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.
Aztreonam is given as an injection into a muscle or through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. Aztreonam is usually given in a clinic or hospital setting. The medicine may need to be given for several hours or several weeks, depending on how severe your infection is.
You may be shown how to inject your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of needles, IV tubing, and other items used in giving the medicine.
Aztreonam is usually given as long as needed until your infection has cleared or you have been symptom-free for at least 48 hours.Use aztreonam for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Aztreonam will not treat a viral infection such as the common cold or flu. Do not give this medication to another person, even if they have the same symptoms you do. Aztreonam is supplied as a frozen solution in a plastic container. If you use this medicine at home, store the frozen medicine in a freezer. If possible, keep the freezer set at 4 degrees below 0 Fahrenheit or colder.
Thaw the medicine either in a refrigerator or at room temperature. Do not heat the medicine to thaw it more quickly. Aztreonam that is thawed in the refrigerator should be used within 2 weeks.If you have thawed the medicine at room temperature, you must use it within 48 hours. Once aztreonam has been thawed, it should be clear and appear colorless or slightly yellow. Do not use the medicine if it has changed color or has particles in it, or if the medicine container leaks. Call your doctor or pharmacist for a new prescription.
Use the medication as soon as you remember the missed dose. If it is almost time for your next dose, skip the missed dose and use the medicine at your next regularly scheduled time. Do not use extra medicine to make up the missed dose.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.
diarrhea that is watery or bloody;
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
confusion, seizure (convulsions);
feeling light-headed, fainting;
pale skin, easy bruising or bleeding, unusual weakness;
fever, chills, body aches, flu symptoms; or
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may be more likely to occur, such as:
mild stomach discomfort;
warmth, redness, or tingly feeling under your skin;
numbness, tingling, or burning pain;
mild skin rash or itching;
vaginal itching or discharge; or
pain, swelling, or irritation where the IV needle is placed.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
The following drugs can interact with aztreonam. Tell your doctor if you are using any of these:
neomycin (Mycifradin, Neo-Fradin, Neo-Tab);
tobramycin (Nebcin, Tobi).
This list is not complete and there may be other drugs that can affect aztreonam. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.