Generic Name: benzocaine and trimethobenzamide (rectal) (BENZ o kain and try meth o BENZ uh myd)Brand names: Tigan Adult, Tigan Pediatric, Navogan, Tebamide, Triban, Tebamide Pediatric
Benzocaine and trimethobenzamide affects the areas of the brain that stimulate nausea and vomiting.
Benzocaine and trimethobenzamide is used to treat nausea and vomiting.
Benzocaine and trimethobenzamide may also be used for purposes other than those listed in this medication guide.What is the most important information I should know about benzocaine and trimethobenzamide?Use caution when driving, operating machinery, or performing other hazardous activities. Benzocaine and trimethobenzamide may cause dizziness, drowsiness, or blurred vision. If you experience dizziness, drowsiness, or blurred vision, avoid these activities. Avoid drinking alcohol, which may increase drowsiness and dizziness while you are taking benzocaine and trimethobenzamide.What should I discuss with my healthcare provider before using benzocaine and trimethobenzamide?
Before using this medication, tell your doctor if you have:
an enlarged prostate;
heart disease or a heart rhythm disorder.
If you have any of these conditions, you may not be able to use benzocaine and trimethobenzamide, or you may need a dosage adjustment or special tests during treatment.It is not known whether benzocaine and trimethobenzamide will be harmful to an unborn baby. Do not take benzocaine and trimethobenzamide without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether benzocaine and trimethobenzamide passes into breast milk. Do not take benzocaine and trimethobenzamide without first talking to your doctor if you are breast-feeding a baby. Do not give this medicine to a child, especially if the child has a fever or has recently had chicken pox.
Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts or for longer than recommended by your doctor.The suppositories are for rectal use. Do not take them by mouth.
Unwrap the suppository when you are ready to insert it. You may wet the tip of the suppository with cold water. Lie down on your side and use your finger to insert the suppository into your rectum. Hold in the suppository and remain lying down for a few minutes while the medicine dissolves.To make the rectal suppository easier to insert, you may chill it in the refrigerator for 30 minutes before use.
Benzocaine and trimethobenzamide is normally used three or four times a day. You may also be using the medicine only as needed. Follow your doctor's instructions.
Do not take more of this medication than is prescribed for you.Store benzocaine and trimethobenzamide suppositories at room temperature away from moisture and heat.
Since benzocaine and trimethobenzamide is used as needed, you may not be on a dosing schedule. If you are using the medication regularly, use the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.
Symptoms of a benzocaine and trimethobenzamide overdose may include drowsiness, uncontrollable movements, muscle spasms, blurred vision, seizures or convulsions, difficulty breathing, and death.
jaundice (yellowing of the skin or eyes);
seizure (convulsions); or
easy bruising or bleeding, unusual weakness;
tremor (uncontrolled shaking); or
muscle cramps, severe muscle spasms.
Other less serious side effects are more likely to occur. Continue using benzocaine and trimethobenzamide and talk with your doctor if you have any of these less serious side effects:
drowsiness or dizziness;
feeling depressed or disoriented; or
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
Usual Adult Dose for Nausea/Vomiting:
200 mg rectally 3 to 4 times a day as needed.
Usual Pediatric Dose for Nausea/Vomiting:
1 to 12 years: 15 to 20 mg/kg/day (400 to 500 mg/m2/day) rectally administered in equally divided doses 3 to 4 times a day as needed.Alternatively:1 to 12 years: < 13.6 kg (30 lbs): 100 mg rectally 3 to 4 times a day as needed.13.6 to 41 kg (30 to 90 lbs): 100 to 200 mg rectally 3 to 4 times a day as needed.
Benzocaine and trimethobenzamide may increase the side effects of other drugs that make you sleepy (such as alcohol, cold medicine, pain medication, muscle relaxants, and medicine for seizures, depression or anxiety). Before using benzocaine and trimethobenzamide, tell your doctor if you are using any of these medicines.
There may be other drugs that can affect benzocaine and trimethobenzamide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
Benzocaine and trimethobenzamide is available with a prescription generically and under the brand name Tigan. Ask your pharmacist any questions you have about this medication, especially if it is new to you.