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Drugs reference index «Benzoyl Peroxide»

Benzoyl Peroxide

Pronunciation: (BEN-zoyl per-OX-ide)Class: Antibiotic agent

Trade Names:Benzac- Liquid 5%- Liquid 10%- Gel 2.5%- Gel 5%- Gel 10%

Trade Names:Benzagel- Gel 10%

Trade Names:Benzoyl Peroxide- Liquid 2.5%- Lotion 5%

Trade Names:Brevoxyl-4- Gel 4%

Trade Names:Brevoxyl-4 Acne Wash Kit- Liquid 4%

Trade Names:Brevoxyl-8- Gel 8%

Trade Names:Brevoxyl-8 Acne Wash Kit- Liquid 8%

Trade Names:Clearasil- Cream 10%

Trade Names:Clinac- Gel 7%

Trade Names:Desquam- Bar 10%- Gel 10%

Trade Names:NeoBenz Micro- Cream 3.5%- Cream 5.5%- Cream 8.5%- Wash 7%

Trade Names:Neutrogena- Cleanser/Mask 3.5%

Trade Names:Oxy- Liquid 10%

Trade Names:PanOxyl- Bar 5%- Bar 10%- Gel 2.5%- Gel 5%- Gel 10%

Trade Names:RE Benzoyl Peroxide- Cream 3.5%- Cream 5.5%- Cream 8.5%

Trade Names:SE BPO- Wash 7%

Trade Names:Triaz- Liquid 3%- Liquid 6%- Liquid 9%- Gel 3%- Gel 6%- Gel 9%

Trade Names:Triaz Cleanser- Lotion 3%- Lotion 6%- Lotion 10%

Benoxyl 5% (Canada)Benoxyl 10% (Canada)Benoxyl 20% (Canada)Clindoxyl (Canada)Panoxyl Antibacterial Acne Creamy Wash (Canada)Panoxyl Aquagel 2.5% and 5% (Canada)Panoxyl 5% (Canada)Panoxyl 5% Wash (Canada)Panoxyl 10% (Canada)Panoxyl 15% (Canada)Panoxyl 20% (Canada)Solugel 4 (Canada)Solugel 8 (Canada)

Pharmacology

Release of active or free-radical oxygen capable of oxidizing bacterial proteins is suspected.

Pharmacokinetics

Absorption

Absorbed by the skin, where it is metabolized to benzoic acid and excreted as benzoate in the urine.

Indications and Usage

Treatment of mild to moderate acne vulgaris and as an adjunct to antibiotics, retinoic acid, and sulfur or salicylic acid-containing products in treating more severe cases of acne.

Contraindications

Standard considerations.

Dosage and Administration

Adults and Children 12 yr of age and older

Topical Cleansers Wash every day or twice daily. Wet skin areas to be treated prior to administration, rinse thoroughly, and pat dry. Control amount of drying or peeling by modifying dose frequency or concentration. Adjust frequency of use to obtain the desired clinical response. Other dose forms After cleaning skin, smooth small amount over affected area every day or twice daily. Reduce dose frequency or concentration if bothersome dryness or peeling occurs. If excessive stinging or burning occurs after any single application, remove with mild soap and water, resuming use the next day.

General Advice

  • For topical use only. Not for ophthalmic, oral, or intravaginal use.
  • Avoid contact with eyes, eyelids, lips, and mucus membranes.
  • Assess the skin and identify areas where medication is to be applied and areas that should be avoided (severely irritated or sunburned skin).
  • Visible improvement will normally occur by wk 3 with max lesion reduction approximately by wk 8 to 12.

Storage/Stability

Store between 59° to 77°F.

Drug Interactions

Tretinoin

Concurrent use may cause severe skin irritation.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Dermatologic

Excessive drying, manifested by marked peeling, erythema, possible edema, and allergic contact sensitization/dermatitis.

Precautions

Monitor

Assess and document skin condition before initial application and periodically throughout treatment. Monitor for side effects, including redness, scaling, dryness, or persistent itching or burning. Inform health care provider if noted and significant. If bothersome dryness or peeling occurs, consider reducing the frequency of application and/or the concentration of the medication.

Pregnancy

Category C .

Lactation

Undetermined.

Children

Safety and efficacy not established in children under 12 yr of age.

Bleaching

Benzoyl peroxide is an oxidizing agent and may bleach hair and colored fabric.

Cross-sensitization

Cross-sensitization may occur with benzoic acid derivatives (eg, cinnamon, certain topical anesthetics).

External use only

Avoid contact with eyes, eyelids, lips, mucous membranes, and highly inflamed or damaged skin. Rinse with water if accidental contact occurs.

Irritation

If severe irritation develops, consult health care provider, discontinue use, and institute appropriate therapy. After reaction clears, treatment may often be resumed with less frequent application.

Sun exposure

Avoid unnecessary exposure to sun and use a sunscreen when using this product.

Overdosage

Symptoms

Excessive scaling, erythema, edema.

Patient Information

  • Advise patient that medication is applied topically to skin lesions every day or twice daily.
  • Teach patient with acne proper technique for applying cream, gel, or lotion: wash hands; thoroughly wash and pat dry area(s) to be treated then apply a thin film of cream, gel, or lotion to cover skin areas with acne lesions. Wash hands after applying medication.
  • Caution patient to avoid contact of medication with hair or colored fabrics because bleaching may occur.
  • Instruct patient to avoid concurrent use of topical alcoholic cleansers, tinctures, astringents, abrasives, and peeling agents unless advised by health care provider.
  • Caution patient not to cover treated areas with bandages or dressings.
  • Warn patient that applying medication more often than prescribed or in excessive quantities will not produce more rapid improvement or better results but will result in greater side effects such as redness, scaling, and discomfort.
  • Advise patient if an application is missed, not to try to make it up but to return to normal application schedule as soon as possible.
  • Warn patient to avoid contact with the eyes, eyelids, lips, and mucous membranes.
  • Advise patient if cream or gel comes in contact with the eyes to wash eyes with large amounts of cool water and to contact health care provider if eye irritation persists.
  • Advise patient that local stinging, burning, tingling, dryness, and redness are the most common side effects and to notify health care provider if they become bothersome.
  • Advise patient if severe skin reactions occur to stop using the medication and contact health care provider.
  • Warn patient to avoid unnecessary exposure to sun and sun lamps while using this medication. Advise patient to use sunscreens and protective clothing over treated areas when exposure cannot be avoided.
  • Advise patient to talk to health care provider before using any other topical agents (eg, medicated soaps, astringents, cosmetics, or other acne products) on treated skin.
  • Advise patient that follow-up visits to examine the skin lesions may be necessary and to keep appointments.

Copyright © 2009 Wolters Kluwer Health.

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