benztropine (Injection route)

Commonly used brand name(s):

In the U.S.

• Cogentin

Available Dosage Forms:

• Solution

Therapeutic Class: Antiparkinsonian

Pharmacologic Class: Anticholinergic

Uses For benztropine

Benztropine injection is used with other medicines to treat Parkinson's disease. By improving muscle control and reducing stiffness, benztropine allows more normal movements of the body as the disease symptoms are reduced. It is also used to control severe reactions to certain medicines that are used to treat nervous, mental, and emotional conditions (e.g., phenothiazine medicine such as prochlorperazine, Compazine®, Mellaril®, Phenergan®, Thorazine®, Trilafon®).

benztropine is available only with your doctor's prescription.

Before Using benztropine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For benztropine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to benztropine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Because of benztropine's toxicity, it should be used with caution in children 3 years of age or older. It is not recommended for use in children below 3 years of age.

Geriatric

No information is available on the relationship of age to the effects of benztropine injection in geriatric patients.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using benztropine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Potassium Chloride

Using benztropine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Betel Nut
• Chlorpromazine
• Haloperidol

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of benztropine. Make sure you tell your doctor if you have any other medical problems, especially:

• Enlarged prostate or
• Glaucoma or
• Paralytic ileus (bowel blockage), history of or
• Psychosis (mental disorder) or
• Tachycardia (fast heartbeat) or
• Urinating problems (e.g., painful or difficult urination, urinary retention)—Use with caution. May make these conditions worse.

• Glaucoma, angle-closure or
• Tardive dyskinesia (movement disorder)—Should not be used in patients with these conditions.

Proper Use of benztropine

A nurse or other trained health professional will give you benztropine in a hospital. benztropine may be given as a shot into one of your muscles or given through a needle placed in one of your veins.

Precautions While Using benztropine

It is important that your doctor check your progress at regular visits to allow changes in your dose and to check for any unwanted effects.

Benztropine injection may cause dizziness, trouble in controlling movements, or trouble in thinking or seeing clearly. Make sure you know how you react to benztropine before you drive, use machines, or do other jobs that require you to be alert, well-coordinated, or able to think or see well.

Do not stop taking benztropine without checking first with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping completely.

benztropine may make you sweat less, causing your body temperature to increase. Use extra care to avoid becoming overheated during exercise or hot weather while you are taking benztropine, since overheating may result in heat stroke.

benztropine may cause muscle weakness. If you have concerns about this, check with your doctor.

If you develop any unusual or strange thoughts and behavior while receiving benztropine injection, be sure to discuss it with your doctor. Some changes that have occurred in people receiving benztropine are like those seen in people who drink too much alcohol. Other changes might be confusion, worsening of depression, visual hallucinations (seeing things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability.

benztropine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your medical doctor or dentist before taking any of the above while you are taking benztropine.

benztropine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

• Abdominal or stomach cramps or pain
• aggressive and violent behavior
• being forgetful
• bloating
• burning while urinating
• confusion about identity, place, and time
• constipation
• decrease in frequency of urination
• decrease in urine volume
• diarrhea
• difficult or painful urination
• difficulty in passing urine (dribbling)
• difficulty with speaking
• difficulty with swallowing
• discouragement
• dizziness
• dry mouth
• extremely high fever or body temperature
• fast, pounding, or irregular heartbeat or pulse
• fast, shallow breathing
• fast, weak heartbeat
• feeling sad or empty
• fever
• headache
• hot, dry skin
• irritability
• lack of appetite
• lack of sweating
• listlessness
• loss of interest or pleasure
• mood or mental changes
• muscle cramps
• muscle weakness
• nervousness
• numbness of the fingers
• pale, clammy skin
• seeing things that are not there
• thirst
• tiredness
• trouble concentrating
• trouble with sleeping
• vomiting

Get emergency help immediately if any of the following symptoms of overdose occur:

• Blindness
• blurred vision
• change in consciousness
• cold, clammy skin
• decreased vision
• dizziness
• eye pain
• holding false beliefs that cannot be changed by fact
• lightheadedness
• loss of consciousness
• muscle weakness
• nausea or vomiting
• no breathing
• nosebleeds
• numbness or tingling in the face, arms, or legs
• shakiness and unsteady walk
• sweating
• tearing
• unsteadiness, trembling, or other problems with muscle control or coordination
• unusual excitement, nervousness, or restlessness
• vision problems
• wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Enlarged pupils
• loss of appetite
• skin rash
• weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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