Bepotastine Besilate
Pronunciation: BEP-oh-TAS-teen BES-il-ateClass: Mast cell stabilizer
Trade Names:Bepreve- Solution, ophthalmic 1.5%
Pharmacology
A highly selective histamine H 1 antagonist that inhibits the release of histamine from mast cells.
Pharmacokinetics
Absorption
T max is 1 to 2 h; C max is approximately 7.3 ng/mL.
Distribution
Protein binding is approximately 55%.
Metabolism
Not extensively metabolized.
Elimination
Approximately 75% to 90% excreted unchanged in the urine.
Indications and Usage
Temporary relief of itching caused by allergic conjunctivitis.
Contraindications
Standard considerations.
Dosage and Administration
Adults and Children 2 yr of age and olderOphthalmic 1 drop in affected eye(s) twice daily.
General Advice
- For topical ophthalmic use only.
- Do not instill while wearing contact lenses. Lenses may be reinserted 10 min following administration.
Storage/Stability
Store between 59° and 77°F. Keep bottle tightly closed.
Drug Interactions
Laboratory Test Interactions
None well documented.
Adverse Reactions
CNS
Headache (2% to 5%).
EENT
Eye irritation, nasopharyngitis (2% to 5%).
Miscellaneous
Mild taste (25%).
Precautions
Pregnancy
Category C .
Lactation
Undetermined.
Children
Safety and effectiveness in children younger than 2 yr of age have not been established.
Elderly
No differences in safety or effectiveness have been observed.
Patient Information
- Advise patient that usual dose is 1 drop in affected eye(s) twice daily.
- Teach patient proper technique for instilling eye drops: wash hands; do not allow dropper to touch eye; tilt head back and look up; pull lower eyelid down; instill prescribed number of drops; close eye for 1 to 2 min and apply gentle pressure to bridge of nose; do not rub eye.
- Advise patients who wear contact lenses to remove their lenses before instilling this medicine and to wait at least 10 min after instilling eye drop before inserting their lenses. Also, caution these patients not to wear their lens if eye is red.
- Advise patient to inform health care provider if experiencing side effects, or if eye symptoms do not improve or they worsen.
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