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Drugs reference index «Besifloxacin»



Pronunciation: (BE-si-FLOX-a-sin)Class: Fluoroquinolone

Trade Names:Besivance- Suspension, ophthalmic 0.6%


Inhibits microbial DNA replication, transcription, repair, and recombination.



C max is less than 1.3 ng/mL.


Average elimination half-life is 7 h.

Indications and Usage

Treatment of bacterial conjunctivitis caused by susceptible organisms.


Standard considerations.

Dosage and Administration

Adults and Children 1 y of age and older

Ophthalmic 1 drop in affected eye(s) 3 times daily 4 to 12 h apart for 7 days.

General Advice

  • For topical ophthalmic use only; should not be injected into the eye.
  • Invert bottle and shake once before using.


Store at 59° to 77°F. Protect from light.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Headache (1% to 2%).


Conjunctival redness (2%); blurred vision, eye irritation, eye pain, eye pruritus (1% to 2%).



Monitor patient for signs and symptoms of ocular adverse reactions (eg, burning, irritation, stinging pain) and improvement in conjunctivitis.


Category C .




Safety and efficacy not established in children younger than 1 y of age.


Prolonged use may result in overgrowth of nonsusceptible microorganisms, including bacteria or fungi.

Contact lenses

Patients should not wear contact lenses.

Patient Information

  • Instruct patients not to wear contact lenses if they have signs or symptoms of bacterial conjunctivitis or during use of the product.
  • Advise patient to avoid contaminating the applicator tip with material from the eye, fingers, or other sources.
  • Advise patient to discontinue use immediately and contact their health care provider at the first sign of rash or allergic reaction.
  • Instruct patient to complete the full course of therapy, even if symptoms of infection have resolved.
  • Advise patient to thoroughly wash hands before using besifloxacin.
  • Instruct patient to invert closed bottle (upside down) and shake once before each use; remove cap with bottle still in the inverted position; tilt head back, and with bottle inverted, gently squeeze bottle to instill 1 drop into the affected eye(s).
  • Notify health care provider if conjunctivitis is not improving or is worsening, or if intolerable adverse reactions occur.

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