Betamethasone / Clotrimazole
Pronunciation: (BAY-tuh-METH-uh-zone/kloe-TRIM-uh-zole)Class: Topical corticosteroid
Trade Names:Lotrisone- Cream 0.05% betamethasone (as dipropionate)/1% clotrimazoleLotriderm
Clotrimazole increases cell membrane permeability in susceptible fungi. Betamethasone has anti-inflammatory, antipruritic, and vasoconstrictive actions.
Indications and Usage
Topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum , T. mentagrophytes , Epidermophyton floccosum , Microsporum canis .
Hypersensitivity to other corticosteroids or imidazoles.
Dosage and Administration
Topical 1 application twice daily (2 wk for tinea cruris and tinea corporis; 4 wk for tinea pedis).
- Wear gloves. Apply medication sparingly and rub in lightly. Notify health care provider if signs of hypersensitivity or irritation are noted.
- Avoid contact with eyes, mouth, and nose.
- Do not cover treated area with dressings or use tight-fitting diapers, plastic pants, or underwear over treated area.
Store cream at room temperature.
None well documented.
Laboratory Test Interactions
None well documented.
Maculopapular rash; erythema; stinging; blistering; peeling; pruritus; urticaria; burning; itching; dryness; acne; decreased pigmentation; striae; skin atrophy.
Edema; secondary infection; adrenal suppression with long-term use over large areas of skin.
Monitor treated sites for irritation or signs of secondary infection, and report any adverse reactions to health care provider.
Category C .
Safety and efficacy not established.
Patients who receive large doses over large surface areas may experience HPA axis suppression.
Do not use for eye infections.
- Remind patient that medication is for external application only and to avoid contact with eyes, nose, and mouth.
- Demonstrate application technique, cautioning patient to apply sparingly and to rub in lightly.
- Tell patient to notify health care provider if there is no improvement after 1 wk for tinea cruris or tinea corporis or after 2 wk for tinea pedis.
- Caution patient against using dressings, tight-fitting diapers, or plastic pants over treated area.
- Tell patients with tinea corporis (ringworm) to wash clothes separately from those of other family members.
- Remind patient to wash hands before and after each application of product.
- Advise patient to complete prescribed treatment, even if infection clears, to prevent relapse.
- Instruct patient to report the following symptoms to health care provider: burning, itching, rash, swelling, redness or blistering in treated area.
Copyright © 2009 Wolters Kluwer Health.