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Drugs reference index «Betamethasone/Clotrimazole»


Betamethasone / Clotrimazole

Pronunciation: (BAY-tuh-METH-uh-zone/kloe-TRIM-uh-zole)Class: Topical corticosteroid

Trade Names:Lotrisone- Cream 0.05% betamethasone (as dipropionate)/1% clotrimazole

Lotriderm (Canada)


Clotrimazole increases cell membrane permeability in susceptible fungi. Betamethasone has anti-inflammatory, antipruritic, and vasoconstrictive actions.

Indications and Usage

Topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum , T. mentagrophytes , Epidermophyton floccosum , Microsporum canis .


Hypersensitivity to other corticosteroids or imidazoles.

Dosage and Administration

Topical 1 application twice daily (2 wk for tinea cruris and tinea corporis; 4 wk for tinea pedis).

General Advice

  • Wear gloves. Apply medication sparingly and rub in lightly. Notify health care provider if signs of hypersensitivity or irritation are noted.
  • Avoid contact with eyes, mouth, and nose.
  • Do not cover treated area with dressings or use tight-fitting diapers, plastic pants, or underwear over treated area.


Store cream at room temperature.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions




Maculopapular rash; erythema; stinging; blistering; peeling; pruritus; urticaria; burning; itching; dryness; acne; decreased pigmentation; striae; skin atrophy.


Edema; secondary infection; adrenal suppression with long-term use over large areas of skin.



Monitor treated sites for irritation or signs of secondary infection, and report any adverse reactions to health care provider.


Category C .




Safety and efficacy not established.

Adrenal suppression

Patients who receive large doses over large surface areas may experience HPA axis suppression.

Ophthalmic use

Do not use for eye infections.

Patient Information

  • Remind patient that medication is for external application only and to avoid contact with eyes, nose, and mouth.
  • Demonstrate application technique, cautioning patient to apply sparingly and to rub in lightly.
  • Tell patient to notify health care provider if there is no improvement after 1 wk for tinea cruris or tinea corporis or after 2 wk for tinea pedis.
  • Caution patient against using dressings, tight-fitting diapers, or plastic pants over treated area.
  • Tell patients with tinea corporis (ringworm) to wash clothes separately from those of other family members.
  • Remind patient to wash hands before and after each application of product.
  • Advise patient to complete prescribed treatment, even if infection clears, to prevent relapse.
  • Instruct patient to report the following symptoms to health care provider: burning, itching, rash, swelling, redness or blistering in treated area.

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