Bexarotene capsules are a member of the retinoid class of drugs that is associated with birth defects in humans. Bexarotene capsules also caused birth defects when administered orally to pregnant rats. Bexarotene capsules must not be administered to a pregnant woman .
Bexarotene capsules are a member of the retinoid class of drugs that is associated with birth defects in humans. Bexarotene capsules also caused birth defects when administered orally to pregnant rats, and therefore must not be administered to a pregnant woman .
Commonly used brand name(s):
In the U.S.
Available Dosage Forms:
Therapeutic Class: Antineoplastic, Dermatological
Chemical Class: Retinoid
Bexarotene belongs to the group of medicines known as retinoids (RET-i-noyds). When applied to the skin, it is used to treat a form a cancer called cutaneous T-cell lymphoma (CTCL). It acts by interfering with the growth of cells of the tumor. It may be used after other drugs have been tried, and the tumor is still a problem.
bexarotene is available only with your doctor's prescription.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For bexarotene, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to bexarotene or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Studies of bexarotene have been done only in adult patients, and there is no specific information comparing the use of bexarotene in children with use in other age groups.
bexarotene has been tested in patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults. However, elderly patients may be more sensitive to the effects of bexarotene.
|All Trimesters||X||Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Using bexarotene with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using bexarotene with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of bexarotene. Make sure you tell your doctor if you have any other medical problems, especially:
Apply enough bexarotene to cover the lesion with a generous coating. Use a cotton tipped applicator or your fingertips to apply the medicine to your skin. If you apply bexarotene with your fingertips, make sure you wash your hands immediately afterwards, to prevent any of the medicine from accidentally getting into your eyes or mouth.
Avoid getting the medicine on the surrounding unaffected skin. Do not apply the medicine near mucosal areas (the inside of your mouth, eyes, nose, rectum or vagina).
Do not cover with bandages or dressings, unless directed to do so by your doctor. Allow the bexarotene to dry before covering with clothing.
The dose of bexarotene will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of bexarotene. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
Use bexarotene exactly as directed by your doctor. Do not use more or less of it, and do not use it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Using too much will increase the risk of side effects, while using too little may not improve your condition.
If you miss a dose of bexarotene, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Every Other Day Application:Apply as soon as possible if you remember it on the day it should be used. However, if you do not remember the missed dose until the next day, apply it at that time. Then skip a day and start applying every other day. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
It is very important that your doctor check you at regular visits to make sure that bexarotene is working properly and to check for unwanted effects.
Bexarotene may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking bexarotene:
Along with its needed effects, a medicine may cause some unwanted effects. Some side effects will have signs or symptoms that you can see or feel. Your doctor may watch for others by doing certain tests. Since the medication is applied externally to the skin, in general, these side effect are less common. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:More common
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More Common
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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