Generic Name: biperiden (bye PEAR i den)Brand Names: Akineton HCl
Biperiden reduces the effects of certain naturally occurring chemicals in your body that may become unbalanced as a result of disease (such as Parkinson's disease), drug therapy, or other causes.
Biperiden is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. It is also used to treat and prevent these same muscular conditions when they are caused by drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), and others.
Biperiden may also be used for purposes other than those listed in this medication guide.
Avoid becoming overheated. Biperiden may cause decreased sweating. This could lead to heat stroke in hot weather or with vigorous exercise.
have ever had an allergic reaction to it,
have narrow-angle glaucoma,
have an obstruction in your bowel or a complication of bowel disease known as megacolon; or
have myasthenia gravis.
Before taking this medication, tell your doctor if you have
an enlarged prostate or difficulty urinating,
epilepsy or another seizure disorder,
heart disease or an irregular heartbeat,
depression or any other psychiatric illness, or
You may need a lower dose or special monitoring during treatment if you have any of the conditions listed above.Biperiden is in the FDA pregnancy category C. This means that it is not known whether it will harm an unborn baby. Do not take biperiden without first talking to your doctor if you are pregnant. It is also not known whether biperiden passes into breast milk. Do not take biperiden without first talking to your doctor if you are breast-feeding a baby.
Take biperiden exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse or doctor to explain them to you.Take each dose with a full glass of water. Take biperiden after a meal if it upsets your stomach.
Biperiden may be taken once or several times a day. The maximum amount of biperiden that should be taken in any one day is eight tablets (16 mg). Follow your doctor's instructions.Store biperiden at room temperature away from moisture and heat.
See also: Biperiden dosage in more detail
Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and only take your next regularly scheduled dose. Do not take a double dose of this medication.
Symptoms of a biperiden overdose include large pupils; warm, dry skin; flushed face; fever; dry mouth; fast or irregular heartbeat; anxiety; hallucinations; confusion; agitation; hyperactivity; loss of consciousness; and seizures.
Avoid becoming overheated. Biperiden may cause decreased sweating. This could lead to heat stroke in hot weather or with vigorous exercise. Try to keep as cool as possible and watch for signs of heat stroke such as decreased sweating, nausea, and dizziness.
an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
fast or irregular heartbeat;
anxiety, hallucinations, confusion, agitation, hyperactivity, or loss of consciousness;
a rash; or
Other, less serious side effects may be more likely to occur. Continue to take biperiden and talk to your doctor if you experience
a dry mouth;
large pupils or blurred vision;
difficulty urinating or constipation;
nervousness or anxiety;
upset stomach; or
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Parkinson's Disease:
2 mg orally 3 to 4 times a day; the dose may be titrated up to a maximum of 16 mg per 24 hours
Usual Adult Dose for Extrapyramidal Reaction:
Neuroleptic-induced: 2 mg orally 1 to 3 times a day
Before taking this medication, tell your doctor if you are taking:
a phenothiazine (used to treat mania, schizophrenia, other psychiatric conditions, and nausea and vomiting) such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), thioridazine (Mellaril), promazine (Sparine), trifluoperazine (Stelazine), and others;
an antihistamine such as diphenhydramine (Benadryl, others), chlorpheniramine (Chlor-Trimeton, others), triprolidine (Actifed, others), brompheniramine (Dimetapp, others), clemastine (Tavist) and others (antihistamines are often found in prescription and over-the-counter cold, allergy, and sleep medicines);
quinidine (Quinora, Quinaglute, Quinidex, Cardioquin);
digoxin (Lanoxin, Lanoxicaps); or
Drugs other than those listed here may also interact with biperiden. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.