Trade Names:Tornalate- Aerosol 0.8% (delivers 0.37 mg/actuation)- Solution for inhalation 0.2%
Relaxes bronchial smooth muscle through beta-2 receptor stimulation.
Bitolterol, a prodrug, is hydrolyzed by esterases in tissues and blood to active moiety colterol.
Primarily excreted in the urine as metabolites.
2 to 3 min.
At least 6 h.
Prevention and treatment of reversible bronchospasm associated with asthma or other obstructive pulmonary diseases.
Oral inhalation 2 inhalations at interval of 1 to 3 min, followed by third inhalation if necessary.Prevention of BronchospasmAdults and Children older than 12 yr of age
Oral inhalation 2 inhalations every 8 h, not to exceed 3 inhalations every 6 h or 2 inhalations every 4 h.Solution for Inhalation
Administer during a 10- to 15-min period.Continuous flow nebulization
1.5 to 3.5 mg (0.75 to 1.75 mL volume) 3 to 4 times/day with an interval of at least 4 h between treatments. Max daily dose, 14 mg.Intermittent flow nebulization
0.5 to 1.5 mg (0.25 to 0.75 mL volume) 3 to 4 times/day with an interval of at least 4 h between treatments. Max daily dose, 8 mg.
None well documented.
May cause decreased potassium level.
Palpitations; tachycardia; irregular pulse; hypertension; angina.
Tremor; lightheadedness; dizziness; nervousness; headache; tiredness.
Throat and mouth irritation.
Cough; increased chest discomfort; dyspnea; bronchospasm.
Category C .
Safety and efficacy in children younger than 12 yr of age not established.
Lower doses may be required.
May inhibit uterine contractions and delay preterm labor.
Toxic symptoms may occur.
Drug may cause CNS stimulation; use cautiously in patients with history of seizures or hyperthyroidism.
Dosage adjustment of insulin or oral hypoglycemic agent may be required.
Paradoxical bronchospasm and cardiac arrest have been associated with excessive inhalant use.
Do not use 2 or more beta-adrenergic aerosol bronchodilators simultaneously because of the potential of additive effects. Do not use as a substitute for oral or inhaled corticosteroids.
Exaggerated adverse reactions, such as tremors, tachycardia, seizures, hypokalemia, anginal pain, and hypertension.