Trade Names:BroveX- Oral suspension 12 mg (as tannate) per 5 mL
Trade Names:BroveX CT- Tablets, chewable 12 mg (as tannate)
Trade Names:Lodrane 24- Capsules, extended-release 12 mg (as maleate)
Trade Names:Lodrane XR- Oral suspension 8 mg (as tannate) per 5 mL
Trade Names:LoHist 12- Tablets, extended-release 6 mg (as maleate)
Trade Names:VaZol- Liquid 2 mg (as maleate) per 5 mL
Competitively antagonizes histamine at H 1 receptor sites.
Relief of sneezing, itchy, watery eyes, itchy nose or throat, and runny nose because of hay fever (allergic rhinitis) or other respiratory allergies. VaZol is also indicated for temporary relief of runny nose and sneezing caused by the common cold; treatment of allergic and nonallergic pruritic symptoms; temporary relief of mild, uncomplicated urticaria and angioedema; amelioration of allergic reactions to blood or plasma loss; adjunctive therapy of anaphylactic reactions.
Newborn or premature infants; nursing mothers; narrow-angle glaucoma; urinary retention; peptic ulcer; during an asthmatic attack; lower respiratory conditions, including asthma; MAOI therapy or for 2 wk after stopping MAOI therapy; allergy to any component of product.
PO 1 or 2 tablets every 12 h.Children 6 to 12 yr of age
PO 1 tablet every 12 h.Children younger than 6 yr of age
PO Do not administer except under advice and supervision of health care provider.Brovex SuspensionAdults and children 12 yr of age and older
PO 5 to 10 mL (1 to 2 tsp [max, 4 tsp per 24 h]).Children 6 to under 12 yr of age
PO 5 mL (1 tsp [max, 2 tsp per 24 h]).Brovex CT TabletsAdults and children 12 yr of age and older
PO 1 or 2 tablets (max, 4 tablets per 24 h).Children 6 to 12 yr of age
PO 1/ 2 to 1 tablet (max, 2 tablets per 24 h).Children 2 to 6 yr of age
PO 1/ 2 tablet (max, 1 tablet per 24 h).Lodrane 24 CapsulesAdults and Children 12 yr of age and older
PO 1 or 2 capsules once daily.Children 6 to 12 yr of age
PO 1 capsule once daily.Children younger than 6 yr of age
PO Do not administer except under advice and supervision of health care provider.Lodrane XR SuspensionAdults and children 12 yr of age and older
PO 5 mL (1 tsp) every 12 h (max, 2 doses per 24 h).Children 6 to 12 yr of age
PO 2.5 mL (½ tsp) every 12 h (max, 2 doses per 24 h).Children 2 to 6 yr of age
PO 1.25 mL (¼ tsp) every 12 h (max, 2 doses per 24 h).Children under 2 yr of age
PO as recommended by physician.VaZol LiquidAdults and Children 12 yr of age and older
PO 10 mL (2 tsp) 4 times daily.Children 6 to 12 yr of age
PO 5 mL (1 tsp) 4 times daily.Children 2 to 6 yr of age
PO 2.5 mL (½ tsp) 4 times daily.Children younger than 2 yr of age
PO Titrate dose based on 0.5 mg/kg/day of brompheniramine maleate in equally divided doses 4 times daily.
Store oral suspension at controlled room temperature (68° to 77°F). Store all other dose forms at controlled room temperature (59° to 86°F).
Effects may be enhanced by brompheniramine.MAOIs
Do not use in patients receiving MAOI therapy or within 14 days of stopping such treatment.Tricyclic antidepressants (eg, amitriptyline)
May prolong or intensify the anticholinergic effects of brompheniramine.
May interfere with diagnostic test results for skin tests using allergen extracts.
Hypotension; palpitations; tachycardia; extrasystoles.
Drowsiness; headache; sedation; sleepiness; dizziness; disturbed coordination; fatigue; confusion; restlessness; excitation; nervousness; tremor; irritability; insomnia; euphoria; paresthesia; vertigo; hysteria; neuritis; convulsions.
Urticaria; drug rash.
Blurred vision; diplopia; tinnitus; acute labyrinthitis; nasal stuffiness.
Dry mouth, nose, and throat; epigastric distress; anorexia; nausea; vomiting; diarrhea; constipation.
Urinary frequency; difficult urination; urinary retention; early menses.
Hemolytic anemia; hypoplastic anemia; thrombocytopenia; agranulocytosis.
Thickening of bronchial secretions; tightness of chest and wheezing.
Anaphylactic shock; photosensitivity; excessive perspiration; chills.
Assess allergy symptoms (eg, cough; rhinitis; nasal congestion; sneezing; watery eyes; itching nose, throat, or eyes) before starting therapy and periodically during therapy. Notify health care provider if symptoms are not improving or are getting worse. Ensure therapy is periodically reviewed to determine if therapy needs to be continued without change or if a dose change (eg, increase, decrease, discontinuation) is indicated.
Category C .
More likely to cause dizziness, sedation, and hypotension in the elderly.
Use with caution in patients with hypertension, heart disease, asthma, hyperthyroidism, increased IOP, diabetes mellitus, prostatic hypertrophy, and bronchial asthma. Also, use with caution in patients with stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy, or bladder neck obstruction.
CNS depression and stimulation, dry mouth, fixed and dilated pupils, flushing, GI symptoms. Antihistamines may cause hallucinations, convulsions, or possibly death, especially in children, while being more likely to cause dizziness, sedation, and hypotension in the elderly.
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