Busulfan Generic Name:
Busulfan (byoo-SUL-fan)Brand Name:
Busulfan may cause severe bone marrow depression, which can reduce the body's ability to fight infection or cancer. Lab tests will be required to monitor therapy. Busulfan may also cause a type of severe anemia (aplastic anemia).
Busulfan is used for:
Preparing the body for a hematopoietic stem cell transplant in combination with another medicine (cyclophosphamide) in patients with chronic myelogenous leukemia.
Busulfan is an alkylating agent. It works by slowing down reproduction and growth of certain white blood cells.
Do NOT use Busulfan if:
- you are allergic to any ingredient in Busulfan
- you are also taking metronidazole
Contact your doctor or health care provider right away if any of these apply to you.
Before using Busulfan :
Some medical conditions may interact with Busulfan . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have bone marrow depression, blood problems (eg, porphyria, thalassemia), a head injury, or a history of seizures (eg, epilepsy)
- if you have undergone chemotherapy or radiation or have previously or are currently taking any other medicines for cancer
Some MEDICINES MAY INTERACT with Busulfan . Tell your health care provider if you are taking any other medicines, especially any of the following:
- Metronidazole, acetaminophen, or itraconazole because the risk of toxic side effects of Busulfan may be increased
This may not be a complete list of all interactions that may occur. Ask your health care provider if Busulfan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Busulfan :
Use Busulfan as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Busulfan is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Busulfan at home, a health care provider will teach you how to use it. Be sure you understand how to use Busulfan . Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Busulfan if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Busulfan , contact your doctor right away.
Ask your health care provider any questions you may have about how to use Busulfan .
Important safety information:
- Busulfan may cause dizziness, drowsiness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Busulfan with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- If Busulfan accidentally spills on your skin, wash it off immediately with soap and water.
- If nausea, vomiting, or loss of appetite occurs, do not stop using your medicine. Ask your doctor, nurse, or pharmacist for ways to lessen these effects.
- Busulfan may lower your resistance to infection. Prevent infection by avoiding contact with people with colds or other infections. Do not touch your eyes or the inside of your nose unless you have thoroughly washed your hands first.
- Busulfan may reduce the number of certain blood cells that are needed for clotting. To prevent bleeding, avoid situations where bruising or injury may occur.
- Check with your doctor before having vaccinations while you are using Busulfan .
- Tell your doctor or dentist that you take Busulfan before you receive any medical or dental care, emergency care, or surgery.
- Busulfan increases the risk of a second cancer in future years. If you have questions about this risk, talk with your doctor.
- Busulfan may cause infertility. Talk with your doctor if you have any questions or concerns.
- LAB TESTS, including liver function tests, blood cell counts, and bone marrow tests, may be performed while you use Busulfan . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Busulfan should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Busulfan has been shown to cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Busulfan while you are pregnant. It is not known if Busulfan is found in breast milk. Do not breast-feed while taking Busulfan .
Possible side effects of Busulfan :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Anxiety; asthma; back pain; blood clots; change in menstrual cycle; chest pain; confusion; constipation; cough; diarrhea; dizziness; dry mouth; fast heart beat; flushing; headache; hiccup; high blood pressure; increased blood sugar levels; indigestion; inflammation at the injection site; itching; joint pain; loss of appetite; lung disorder; muscle pain; nausea; nosebleed; pain; rash; rectal disorder; runny nose; sinus inflammation; sleeplessness; swelling; tiredness; weakness.Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or vision changes; congestion; decreased ability to fight infection; depression; fever, chills, or sore throat; hallucinations; irregular heartbeat; loss of consciousness; missed menstrual period; pain and distention of the abdomen; pain, redness, or swelling at the injection site; pale skin; persistent cough; rapid weight gain; rash; seizures; shortness of breath; stomach pain; sudden onset of sweating; unusual bruising or bleeding; unusual tiredness or fatigue; vomiting; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.Proper storage of Busulfan :
Store Busulfan as directed on the prescription label. Store away from heat and light. Do not store in the bathroom. Keep Busulfan , as well as needles and syringes, out of the reach of children and away from pets.
- If you have any questions about Busulfan , please talk with your doctor, pharmacist, or other health care provider.
- Busulfan is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Busulfan . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
- Busulfan Professional Patient Advice (Wolters Kluwer)
- busulfan Concise Consumer Information (Cerner Multum)
- busulfan Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information
- Busulfex Prescribing Information (FDA)
- Myleran Prescribing Information (FDA)