Trade Names:Esgic- Capsules 325 mg acetaminophen/40 mg caffeine/50 mg butalbital- Tablets 325 mg acetaminophen/40 mg caffeine/50 mg butalbital
Trade Names:Esgic-Plus- Tablets 500 mg acetaminophen/40 mg caffeine/50 mg butalbital- Capsules 500 mg acetaminophen/40 mg caffeine/50 mg butalbital
Trade Names:Fioricet- Tablets 325 mg actaminophen/40 mg caffeine/50 mg butalbital
Trade Names:Margesic- Capsules 325 mg acetaminophen/40 mg caffeine/50 mg butalbital
Trade Names:Medigesic- Capsules 325 mg acetaminophen/40 mg caffeine/50 mg butalbital
Trade Names:Repan- Tablets 325 mg acetaminophen/40 mg caffeine/50 mg butalbital
Trade Names:Triad- Capsules 325 mg acetaminophen/40 mg caffeine/50 mg butalbital
Butalbital has generalized depressant effect on CNS and, in very high doses, has peripheral effects. Acetaminophen has analgesic and antipyretic effects; its analgesic effects may be mediated through inhibition of prostaglandin synthetase enzyme complex. Caffeine is thought to produce constriction of cerebral blood vessels.
Relief of symptom complex of tension (or muscle contraction) headache.
Hypersensitivity to acetaminophen, caffeine, or barbiturates; porphyria.
PO 1 to 2 tablets or capsules every 4 h; max, 6 tablets or capsules/day.
Store in airtight, light-resistant container at room temperature.
Effects of these drugs may be decreased.
Carbamazepine, sulfinpyrazoneMay increase risk of hepatotoxicity.
MAOIsMay increase CNS effects.
Other CNS depressants (eg, ethanol, narcotics, general anesthetics, tranquilizers, sedative-hypnotics)Increased drowsiness, dizziness, and other CNS depressive effects may occur.
Tricyclic antidepressantsAntidepressant effect may decrease.
With Chemstrip bG and Dextrostix home blood glucose systems, may cause false decrease in mean glucose values; may give false-positive urinary 5-hydroxyindoleacetic acid test result.
Drowsiness; dizziness; lightheadedness; confusion.
Rash.
Nausea; vomiting; flatulence.
Category C .
Undetermined.
Safety and efficacy in children younger than 12 yr of age not established.
Prolonged use may produce drug tolerance and dependency (psychologic and physical).
Blood dyscrasias, respiratory depression, hepatic damage, drowsiness, confusion, coma, hypotension, tachycardia, hypovolemic shock, nausea, vomiting, insomnia, restlessness, tremor.
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