Trade Names:Fioricet with Codeine- Capsules 30 mg codeine phosphate/325 mg acetaminophen/40 mg caffeine/50 mg butalbital
Butalbital has generalized depressant effect on CNS and, in very high doses, has peripheral effects. Acetaminophen has analgesic and antipyretic effects; its analgesic effects may be mediated through inhibition of prostaglandin synthetase enzyme complex. Caffeine is thought to produce constriction of cerebral blood vessels. Codeine binds to opiate receptors in the CNS, causing inhibition of ascending pain pathways and altering perception of and response to pain.
Relief of symptom complex of tension (or muscle contraction) headache.
Hypersensitivity to acetaminophen, caffeine, opiates, or barbiturates; porphyria.
PO 1 to 2 tablets or capsules every 4 h; max, 6 tablets or capsules/day.
Store in airtight, light-resistant container at room temperature.
Effects of these drugs may be decreased.Carbamazepine, sulfinpyrazone
May increase risk of hepatotoxicity.MAOIs
May increase CNS effects.Other CNS depressants (eg, ethanol, narcotics, general anesthetics, tranquilizers, sedative-hypnotics)
Increased drowsiness, dizziness and other CNS depressive effects may occur.Tricyclic antidepressants
Antidepressant effects may decrease.
With Chemstrip bG and Dextrostix home blood glucose systems, may cause false decrease in mean glucose values; may increase serum amylase; may give false-positive urinary 5-hydroxyindoleacetic acid test results.
Drowsiness; dizziness; lightheadedness; confusion; intoxicated feeling.
Nausea; vomiting; flatulence; constipation.
Shortness of breath.
Category C .
Safety and efficacy in children younger than 12 yr of age not established.
Delivery may be prolonged and newborn may experience respiratory depression or withdrawal.
Prolonged use may produce drug tolerance and dependency (psychologic and physical).
Respiratory depressant effects may be enhanced and CSF pressure may be increased.
Blood dyscrasias, respiratory depression, hepatic damage, drowsiness, confusion, coma, hypotension, hypovolemic shock, nausea, tremor, vomiting, tachycardia, insomnia, restlessness.
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