Generic Name: capreomycin (KAP ree oh MYE sin)Brand Names: Capastat Sulfate
Capreomycin is an antibiotic that fights bacteria in the body.
Capreomycin is used to treat Mycobacterium tuberculosis.
Capreomycin is usually given after other tuberculosis medications have been tried without successful treatment of the infection.
Capreomycin may also be used for other purposes not listed in this medication guide.
Before using capreomycin, tell your doctor if you are allergic to any drugs, or if you have kidney disease or hearing impairment.To be sure this medication is not causing harmful effects, your kidney function will need to be tested on a regular basis. Your hearing may also need to be checked. Do not miss any scheduled appointments.
Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Capreomycin will not treat a viral infection such as the common cold or flu.
Stop using this medicine if you have a serious side effect such as hearing loss, ringing in your ears, spinning sensation, problems with balance, extreme thirst, leg discomfort, muscle weakness, limp feeling, or urinating less than usual or not at all.
Before using capreomycin, tell your doctor if you are allergic to any drugs, or if you have:
kidney disease; or
If you have any of these conditions, you may need a dose adjustment or special tests to safely use capreomycin.FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether capreomycin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Capreomycin is given as an injection through a needle placed into a vein or a muscle. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to use your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of needles, IV tubing, and other items used in giving the medicine.
This medicine must be given slowly when given through an IV infusion, and can take up to 60 minutes to complete.
You will need to mix capreomycin with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medication.
Do not draw your dose into a syringe until you are ready to give yourself an injection. Do not use the medication if it has changed colors or has any particles in it. Call your doctor for a new prescription.
Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.To be sure this medication is not causing harmful effects, your kidney function will need to be tested on a regular basis. Your hearing may also need to be checked. Do not miss any scheduled appointments. If you need to have any type of surgery, tell the surgeon ahead of time that you are using capreomycin. You may need to stop using the medicine for a short time.
Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Capreomycin will not treat a viral infection such as the common cold or flu.Store capreomycin at room temperature away from moisture and heat.
Use the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up the missed dose.
Overdose symptoms may include hearing problems, ringing in your ears, dizziness, or urinating less than usual.
Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using capreomycin.
urinating less than usual or not at all;
changes in your hearing;
spinning sensation, problems with balance;
ringing or roaring sound in your ears; or
low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling).
Less serious side effects may include:
mild skin rash;
fever, chills, body aches, flu symptoms; or
pain, swelling, or a hard lump where the injection was given.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Tuberculosis -- Active:
10 to 15 mg/kg (up to 1 g) IM or IV once every 24 hours or 5 days a week.
Usual Pediatric Dose for Tuberculosis -- Active:
15 to 30 mg/kg (up to 1 g) IM or IV 5 to 7 days per week, in 1 or 2 divided doses.
Capreomycin can be harmful to the kidneys, and these effects are increased when it is used together with other medicines that can harm the kidneys. Before using capreomycin, tell your doctor if you are also using:
any other antibiotic (taken by mouth or injected);
methotrexate (Rheumatrex, Trexall);
pain or arthritis medicines such as aspirin (Anacin, Excedrin), acetaminophen (Tylenol), diclofenac (Cataflam, Voltaren), etodolac (Lodine), ibuprofen (Advil, Motrin), indomethacin (Indocin), naproxen (Aleve, Naprosyn), and others;
medicines used to treat ulcerative colitis, such as mesalamine (Pentasa) or sulfasalazine (Azulfidine);
medicines used to prevent organ transplant rejection, such as sirolimus (Rapamune) or tacrolimus (Prograf);
antiviral medicines such as adefovir (Hepsera), cidofovir (Vistide), or foscarnet (Foscavir); or
cancer medicine such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), plicamycin (Mithracin), streptozocin (Zanosar), or tretinoin (Vesanoid).
You may need dose adjustments or special tests when taking any of these medications together with capreomycin.
This list is not complete and there may be other drugs that can interact with capreomycin. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.