Trade Names:Axona- Powder for oral solution 40 g (20 g of medium-chain triglycerides [MCTs])
Induces hyperketonemia and provides an alternative energy substrate to glucose in the brains of patients with Alzheimer disease.
After oral administration, caprylidene is processed by lipase in the gut, and the resulting medium-chain fatty acids are absorbed into the portal vein.
The ketone body beta-hydroxybutyrate crosses the blood-brain barrier and is then taken up by neurons.
The medium-chain fatty acids rapidly pass directly to the liver, where they undergo obligate oxidation.
No clinical studies have been performed in patients with renal insufficiency.Hepatic Function Impairment
No clinical studies have been performed in patients with hepatic insufficiency.Children
No clinical studies have been performed in children.Gender
No significant findings were associated with patient's response by sex.Race
No significant findings were associated with patient's response by race or ethnicity.
For the clinical dietary management of the metabolic processes associated with mild to moderate Alzheimer disease.
Allergy to milk or soy.
PO 40 g/day (1 packet of caprylidene powder, containing 20 g of MCTs) taken during breakfast.
Store at 59° to 86°F, sealed and protected from light and moisture.
None well documented.
Dizziness (7%); headache (6%); fatigue (4%).
Diarrhea (24%); nausea (20%); abdominal distension, flatulence (17%); dyspepsia (9%); abdominal pain (5%).
Urinary tract infection (5%).
Cough, rhinitis (4%).
Periodically monitor triglycerides in patients who meet the criteria indicative of metabolic syndrome.
No clinical studies have been performed in children.
Contains palm or coconut oil, caseinate (milk-derived protein), whey (milk), and lecithin (soy). Do not administer to patients with known allergies to these components.
Observed in patients with probable metabolic syndrome.
Use with caution in patients with a history of GI inflammatory conditions, such as irritable bowel syndrome, diverticular disease, chronic gastritis, and severe gastroesophageal reflux disease.
Use with caution in patients at risk for ketoacidosis (eg, alcoholism, poorly controlled diabetes).
Mild increases in BUN, uric acid, or creatinine were observed.
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