Trade Names:Capsin- Lotion 0.025%- Lotion 0.075%
Trade Names:Capzasin-P- Cream 0.025%
Trade Names:Icy Hot PM- Patch 0.025%
Trade Names:No Pain-HP- Roll-On 0.075%
Trade Names:Pain Doctor- Cream 0.025%
Trade Names:Pain-X- Gel 0.05%
Trade Names:Qutenza- Patch 8%
Trade Names:R-Gel- Gel 0.025%
Trade Names:Zostrix- Cream 0.025% in emollient base
Trade Names:Zostrix-HP- Cream 0.075% in emollient base
Trade Names:Zostrix Neuropathy- Cream 0.25%Capsaicin HP (Canada)
May deplete and prevent reaccumulation of substance P, principal transmitter of pain impulses, from periphery to CNS.Prescription
Causes an initial enhanced stimulation of the transient receptor potential vanilloid 1 receptor (TRPV1)–expressing cutaneous nociceptors, which is followed by pain relief thought to be mediated by a reduction in TRPV1-expressing nociceptive nerve endings.
Temporary relief of pain from rheumatoid arthritis, osteoarthritis, muscle strains, sprains, bruises, and backache; relief of neuralgias (eg, pain after shingles, diabetic neuropathy).Prescription
For the management of neuropathic pain associated with postherpetic neuralgia.
Temporary relief of pain of psoriasis, vitiligo, intractable pruritus, postmastectomy and postamputation neuroma (phantom limb syndrome), vulvar vestibulitis, apocrine chromidrosis, reflex sympathetic dystrophy.
None well documented.
Apply to affected area 3 to 4 times daily or less.Adults and Children 10 yr of age and older ( Zostrix Neuropathy )
Apply a thin film of cream using applicator pad 2 to 4 times daily.Icy Hot PM (adults only)
Remove backing from patch and apply 1 patch to affected area no more than 3 to 4 times daily.PrescriptionNeuropathic pain Adults
Topical Apply a single 60-min application of up to 4 patches. May repeat every 3 mo or as warranted by the return of pain (not more frequently than every 3 mo).
Store at 59° to 86°F.Prescription
Store carton between 68° and 77°F. Excursions between 59° and 86°F are allowed. Keep the patch in the sealed pouch until immediately before use.
Capsaicin, including topical use, may cause or exacerbate coughing associated with ACE inhibitor treatment and vice versa. If a severe cough develops in patients taking an ACE inhibitor and using capsaicin, one or both drugs may need to be discontinued.
Burning sensation, dizziness, dysgeusia, headache, hyperesthesia, hypoesthesia, peripheral sensory neuropathy.
Burning, erythema, stinging.Prescription
Pruritus (2%); abnormal skin odor.
Nausea (5%); vomiting (3%).
Erythema (63%); pain (42%); papules, pruritus (6%); edema (4%); dryness, swelling (2%); anesthesia, bruising, dermatitis, excoriation, exfoliation, hyperesthesia, inflammation, paresthesia, peripheral edema, urticaria, warmth.
Cough, respiratory irritation.Prescription
Nasopharyngitis (4%); sinusitis (3%); bronchitis (2%); cough, throat irritation.
Assess location and intensity of pain periodically throughout therapy.Prescription
Monitor BP periodically.
Category C (OTC); Category B (prescription).
Do not use Zostrix Neuropathy in children younger than 10 yr of age. Do not use Icy Hot PM in children younger than 18 yr of age. Safety and effectiveness of capsaicin prescription patches have not been studied in children younger than 18 yr of age.
Note that transient burning may occur during initial course of therapy but will decrease in a few days. Burning is more common when medication is applied more than 3 times daily.
Do not apply to the face or scalp. Remove patches gently and slowly to avoid aerosolization of capsaicin. If skin not intended to be treated comes in contact with capsaicin, apply cleansing gel for 1 min, wipe off with dry gauze, and wash the areas with soap and water. Treat acute pain during and following the application procedure with local cooling (ice pack) and/or appropriate analgesics.
Increased BP may occur.
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