Trade Names:Capozide 50/25- Tablets 50 mg captopril and 25 mg hydrochlorothiazide
Trade Names:Capozide 25/25- Tablets 25 mg captopril and 25 mg hydrochlorothiazide
Trade Names:Capozide 50/15- Tablets 50 mg captopril and 15 mg hydrochlorothiazide
Trade Names:Capozide 25/15- Tablets 25 mg captopril and 15 mg hydrochlorothiazide
Competitively inhibits angiotensin I-converting enzyme, resulting in the prevention of angiotensin I conversion to angiotensin II, a potent vasoconstrictor that also stimulates aldosterone secretion. This action results in a decrease in sodium and fluid retention, increase in diuresis, and a decrease in BP.Hydrochlorothiazide
Increases chloride, sodium, and water excretion by interfering with transport of sodium ions across renal tubular epithelium.
Treatment of hypertension.
Anuric patients; patients hypersensitive to captopril or any other ACE inhibitor, hydrochlorothiazide, or other sulfonamide derivative.
PO Capozide may be substituted for previously titrated individual components. Alternatively, therapy may be started with a single Capozide tablet (25 mg captopril combined with 15 mg hydrochlorothiazide) every day. For patients not responding sufficiently, the dose may be titrated upward, usually at 6-wk intervals. Maximum daily dose should not exceed 150 mg of captopril or 50 mg of hydrochlorothiazide.
Give dose 1 h before or 2 h after meals.
Store tablets at controlled room temperature (59° to 86°F). Keep container tightly closed and protect from moisture.
Orthostatic hypotension may be potentiated.Anticoagulants (eg, warfarin)
Anticoagulant effect may be decreased.Antidiabetic agents (eg, insulin, sulfonylureas)
Dosage adjustment may be necessary because of possible hydrochlorothiazide-induced elevation in blood glucose levels.Antigout agents (eg, probenecid)
Dosage adjustment may be necessary because of possible hydrochlorothiazide-induced elevation in blood uric acid levels.Cardiac glycosides (eg, digoxin)
Possible digitalis toxicity associated with hypokalemia.Cholestyramine, colestipol
May impair the absorption of hydrochlorothiazide.Food
Reduces bioavailability of captopril.Lithium
Plasma levels of lithium may be elevated, increasing the risk of toxicity.NSAIDs
May reduce the natriuretic and antihypertensive effect of hydrochlorothiazide.Potassium supplements, potassium-sparing diuretics (eg, spironolactone)
Increased risk of hyperkalemia.Nondepolarizing muscle relaxants (eg, tubocurarine)
Effects may be increased.
May cause false-positive urine acetone test.Hydrochlorothiazide
May cause diagnostic interference of bentiromide test; may decrease serum protein-bound iodine levels without signs of thyroid disturbances; may cause diagnostic interference of serum electrolyte levels, blood and urine glucose levels, serum bilirubin levels, and serum uric acid levels.
Hypotension; tachycardia; chest pain; palpitations; angina pectoris; MI; Raynaud syndrome; CHF; cardiac arrest; cerebrovascular accident; rhythm disturbances; orthostatic hypotension; syncope.Hydrochlorothiazide
Orthostatic hypotension; necrotizing angiitis.
Ataxia; confusion; depression; nervousness; somnolence.Hydrochlorothiazide
Dizziness; vertigo; paresthesia; headache; xanthopsia; restlessness.
Rash; pruritus; pemphigoid-like lesion; photosensitivity; bullous pemphigus; erythema multiforme (including Stevens-Johnson syndrome); exfoliative dermatitis.Hydrochlorothiazide
Purpura; photosensitivity; rash; urticaria.
Glossitis; blurred vision.Hydrochlorothiazide
Transient blurred vision.
Dysgeusia; pancreatitis; dyspepsia.Hydrochlorothiazide
Anorexia; gastric irritation; nausea; vomiting; cramping; diarrhea; constipation; jaundice (intrahepatic cholestatic jaundice); pancreatitis; sialadenitis.
Proteinuria; gynecomastia; impotence.Hydrochlorothiazide
Neutropenia; agranulocytosis; anemia; thrombocytopenia; pancytopenia; eosinophilia; aplastic anemia; hemolytic anemia.Hydrochlorothiazide
Leukopenia; agranulocytosis; thrombocytopenia; aplastic anemia; hemolytic anemia.
Jaundice; hepatitis, including necrosis and cholestasis.
Hyperglycemia; hyperuricemia; hypokalemia; hyponatremia.
Bronchospasm; eosinophilic pneumonitis; rhinitis; persistent dry cough.Hydrochlorothiazide
Respiratory distress, including pneumonitis.
Fever; arthralgia; angioedema; anaphylactoid reactions; asthenia; myalgia; myasthenia; syndrome including fever, myalgia, arthralgia, interstitial nephritis, vasculitis, rash or other dermatologic symptoms, eosinophilia, and elevated erythrocyte sedimentation rate.Hydrochlorothiazide
Muscle spasm; weakness; fever; anaphylactic reactions.
When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, discontinue therapy as soon as possible.
Monitor blood sugar in diabetic patient when drug is started or dose is changed. Report significant changes to health care provider.BP
Monitor and record BP and pulse. Should hypotension result, hold medication and notify health care provider.Serum electrolytes
Ensure that serum electrolytes are monitored periodically.WBC
Ensure that WBC with differential is determined prior to starting treatment, every 2 wk for 3 mo, and periodically thereafter in hypertensive patients with renal function impairment or CHF.
Category D (second and third trimester); Category C (first trimester). ACE inhibitors (eg, captopril) can cause injury or death to fetus if used during second or third trimester. When pregnancy is detected, discontinue as soon as possible.
Excreted in breast milk.
Safety and efficacy not established.
Use with caution.
Use with caution.
Use with extreme caution in patients with hereditary angioedema. Angioedema associated with laryngeal edema may be fatal.
Decreases in BP may occur, especially in salt- or volume-depleted patients as a result of dialysis, prolonged diuretic therapy, dietary salt restriction, diarrhea, or vomiting. Volume and salt depletion should be corrected before initiating therapy with benazepril/hydrochlorothiazide.
Has occurred with other ACE inhibitors.
Dehydration, electrolyte disturbances, hypotension, CNS depression, lethargy, coma.
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