lee-voe-DOE-pa, kar-bi-DOE-pa, en-TAK-a-pone
Commonly used brand name(s):
In the U.S.
Available Dosage Forms:
Therapeutic Class: Antiparkinsonian
Pharmacologic Class: Dopamine Precursor
Carbidopa, entacapone and levodopa is used to treat Parkinson's disease, sometimes referred to as shaking palsy. Parkinson's disease is a disorder of the central nervous system (brain and spinal cord).
Dopamine is a naturally occurring substance in the brain that helps provide control of movement and activities such as walking and talking. In patients with Parkinson's disease there is not enough dopamine in some parts of the brain. Levodopa (a component of carbidopa, entacapone, and levodopa) enters the brain and helps replace the missing dopamine, which allows people to function better. By increasing the amount of dopamine in the brain levodopa helps control symptoms and helps you to perform daily activities such as dressing, walking and handling utensils.
carbidopa, entacapone, and levodopa is a combination of three different medicines. carbidopa, entacapone, and levodopa is known as a levodopa therapy. The difference between carbidopa, entacapone, and levodopa and other levodopa therapies is that carbidopa, entacapone, and levodopa also has entacapone in it. Entacapone helps levodopa last longer by blocking a substance called COMT enzyme. This enzyme breaks down levodopa before it reaches the brain. When less levodopa is broken down, more is available to the brain. Increased availability of levodopa may lead to smoother and steadier levels of dopamine in the brain, which may provide better symptom control for longer periods each day. This may lead to improvement in daily activities.
carbidopa, entacapone, and levodopa is available only with your doctor's prescription.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For carbidopa, entacapone, and levodopa, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to carbidopa, entacapone, and levodopa or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Studies on carbidopa, entacapone, and levodopa have been done only in adult patients, and there is no specific information comparing use of carbidopa, entacapone or levodopa in children with use in other age groups.
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work the same way in older people as they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing the use of carbidopa, entacapone and levodopa combination in the elderly with use in other age groups.
|All Trimesters||C||Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Using carbidopa, entacapone, and levodopa with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using carbidopa, entacapone, and levodopa with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using carbidopa, entacapone, and levodopa with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
The presence of other medical problems may affect the use of carbidopa, entacapone, and levodopa. Make sure you tell your doctor if you have any other medical problems, especially:
Since protein may interfere with the body's response to levodopa, high protein diets should be avoided. Intake of normal amounts of protein should be spaced equally throughout the day, or taken as directed by your doctor.
It is very important that you take your medicine exactly as directed, and every time that you are supposed to take it. It is important that you do not stop taking your medication unless ordered by your doctor. It is also important to not start taking other medicines for your Parkinson's disease without first talking with your doctor.
You may experience a “wearing-off” effect towards the end of the dosing interval. You should tell your doctor if you have problems with this that affect your every day life. Your doctor may want to adjust your dose.
carbidopa, entacapone, and levodopa begins to release its ingredients 30 minutes after you take it.
It is possible that a dark color (red, brown, or black) may appear in saliva, urine, or sweat after taking carbidopa, entacapone, and levodopa. The color may cause some of your garments to become discolored.
It is important to discuss with your doctor any change to your diet. High protein diets or too much acidity in your stomach may cause problems with the way carbidopa, entacapone, and levodopa is absorbed by your body.
If you are taking multi-vitamin tablets or plan to start taking them discuss this with your doctor. Iron salts (in vitamins) may cause carbidopa, entacapone, and levodopa not to work as well.
The dose of carbidopa, entacapone, and levodopa will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of carbidopa, entacapone, and levodopa. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not refrigerate. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
It is important to understand that hypotension (decrease in blood pressure, especially when getting up from a sitting position) may develop. This may occur more frequently when you are beginning treatment with the medicine or when your dosage is increased.
You should get up carefully after sitting or lying down, especially if you have been doing so for long periods of time. You should use extra caution when getting up after sitting or lying down, especially during the beginning of treatment with carbidopa, entacapone and levodopa combination.
It is very important that you discuss new medications with your doctor before starting any new medications.
It is possible that you may experience hallucinations (seeing or hearing things that are not there) or an increase in dyskinesia (trouble in moving). Talk with your doctor if you have any questions about this.
It is possible that you may become nauseous, especially when you are first starting your medicine.
It is important to tell your doctor if you are pregnant or breast-feeding or are planning to become pregnant or planning to breast feed your baby.
carbidopa, entacapone, and levodopa may cause some people to become drowsy, dizzy, or less alert than they are normally. Make sure you know how you react to carbidopa, entacapone, and levodopa before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:More common-Entacapone
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common-Entacapone
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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