Pronunciation: (car-bih-NOCK sah-meen MAL-ee-ate)Class: Ethanolamines, nonselective
Trade Names:Histex CT- Tablets, timed-release 8 mg
Trade Names:Histex I/E- Capsules, variable-release 2 mg/8 mg
Trade Names:Histex Pd- Liquid 4 mg per 5 mL
Trade Names:Palgic- Tablets 4 mg
Trade Names:Pediatex- Liquid 1.75 mg per 5 mL
Trade Names:Pediatex 12- Suspension 3.6 mg per 5 mL
Competitively antagonizes histamine at H 1 receptor sites.
The t ½ is 10 to 20 h. No intact drug is excreted in the urine.
Indications and Usage
Symptomatic treatment of nasal and nonnasal seasonal and perennial allergic rhinitis. Palgic tablets also are indicated for vasomotor rhinitis; allergic conjunctivitis caused by inhalant allergens and foods; mild, uncomplicated allergic skin manifestations of urticaria and angioedema; dermatographism; as therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled.
MAOI therapy; newborn or premature infants; lower respiratory tract symptoms, including asthma; breast-feeding mothers; hypersensitivity to any component of the product.
Dosage and AdministrationHistex CT TabletsAdults and children (12 yr of age and older)
PO 8 mg every 12 h.Children (6 to 12 yr of age)
PO 4 mg every 12 h.Children younger than 6 years of age
Not recommended.Histex I/EAdults and children 12 yr of age and older
PO 1 capsule (2 mg/8 mg) every 12 h (max, 2 capsules in 24 h).Histex Pd LiquidAdults and children (6 yr of age and older)
PO 5 mL (4 mg) 4 times daily.Children (18 mo to 6 yr of age)
PO 2.5 mL (2 mg) 4 times daily.Children (9 to 18 mo of age)
PO 1.25 to 2.5 mL (1 to 2 mg) 4 times daily.PalgicAdults
PO 1 or 2 tablets (4 to 8 mg) 3 or 4 times daily.Children older than 6 yr of age
PO 1 to 1½ tablets (4 to 6 mg) 3 or 4 times daily.Children 3 to 6 yr of age
PO ½ to 1 tablet (2 to 4 mg) 3 or 4 times daily.Children 1 to 3 yr of age
PO ½ tablet (2 mg) 3 or 4 times daily.Pediatex LiquidAdults and children (6 yr of age and older)
PO 10 mL (3.5 mg) 4 times daily.Children (18 mo to 6 yr of age)
PO 5 mL (1.75 mg) 4 times daily.Children (9 to 18 mo of age)
PO 3.75 to 5 mL (1.3 to 1.75 mg) 4 times daily.Children (6 to 9 mo of age)
PO 3.75 mL (1.3 mg) 4 times daily.Children (3 to 6 mo of age)
PO 2.5 mL (0.875 mg) 4 times daily.Children (1 to 3 mo of age)
PO 1.25 mL (0.44 mg) 4 times daily.Pediatex 12 SuspensionAdults and children 12 yr of age and older
PO 10 to 20 mL (7.2 to 14.4 mg) every 12 h.Children 6 to 12 yr of age
PO 5 to 10 mL (3.6 to 7.2 mg) every 12 h.Children 2 to 6 yr of age
PO 2.5 to 5 mL (1.8 to 3.6 mg) every 12 h.
- Administer without regard to meals. Administer with food if GI upset occurs.
- Timed-release tablets can be broken in half without affecting release of medication. Advise patient not to crush or chew tablets or half-tablets.
- Advise patient to swallow extended release capsule whole and not to crush, chew, or open the capsule.
- Shake oral suspension well before measuring dose. Measure and administer prescribed dose using dosing syringe, dosing spoon, or dosing cup.
- Use caution when administering oral liquid. Note that there are 2 concentrations (1.75 mg per 5 mL and 4 mg per 5 mL) available. Administering the wrong liquid can result in an overdose or underdose. Measure and administer prescribed dose using dosing syringe, dosing spoon, or dosing cup.
Store all dose forms at controlled room temperature (59° to 86°F). Protect oral suspension from freezing.
Drug InteractionsAlcohol, barbiturates (eg, phenobarbital), tricyclic antidepressants (eg, amitriptyline), other CNS depressants
Effects may be enhanced by carbinoxamine.MAOIs
May prolong and intensify the effects of carbinoxamine.
Laboratory Test Interactions
May interfere with diagnostic test results for skin tests using allergen extracts.
Sedation; dizziness; headache; nervousness; nausea; anorexia; heartburn; weakness; disturbed coordination; excitability in children.
Vomiting; diarrhea; dry mouth; epigastric distress.
Thickening of bronchial secretions.
Assess allergy symptoms (eg, cough, rhinitis, nasal congestion, sneezing, watery eyes, or itching nose, throat, or eyes) before starting therapy and periodically during therapy. Notify health care provider if symptoms are not improving or are getting worse.Review therapy
Ensure that therapy is periodically reviewed to determine if therapy needs to be continued without change or if a dose change (eg, increase, decrease, discontinuation) is indicated.
Category C .
Ensure that orders for liquid carbinoxamine contain the concentration (1.75 mg per 5 mL or 4 mg per 5 mL) of the liquid to be administered.
In young children, predominant symptoms include the following: excitation, hallucination, ataxia, incoordination, tremors, flushed face, fever, convulsions, fixed and dilated pupils, coma, death. In adults, predominant symptoms include the following: fever, flushing, excitement, convulsions, postictal depression preceded by drowsiness and coma, respiratory depression.
- Advise patient to take each dose without regard to meals but to take with food if stomach upset occurs.
- Advise patient using immediate-release tablets to take prescribed dose 3 or 4 times daily as ordered.
- Advise patient using timed-release tablets to take prescribed dose every 12 h. Advise patient that timed-release tablet can be broken in half without affecting release of the medication but that tablets and half-tablets should not be crushed or chewed.
- Advise patient using extended-release capsules to take prescribed dose every 12 h. Caution patient to swallow capsules whole and not to crush, chew, or open the capsule.
- Advise patient or caregiver using oral suspension to administer prescribed dose every 12 h. Advise patient or caregiver to shake suspension well before measuring dose and to measure and administer prescribed dose using dosing syringe, dosing spoon, or dosing cup.
- Advise patient or caregiver using oral liquid to administer prescribed dose 4 times daily. Advise patient or caregiver to measure and administer prescribed dose using dosing syringe, dosing spoon, or dosing cup.
- Advise patient that if a dose is missed to take it as soon as possible unless it is nearing time for the next scheduled dose, then advise patient to skip the missed dose and take the next dose at the regularly scheduled time. Caution patient not to double the dose to catch up.
- Advise patient that if allergy symptoms are not controlled not to increase the dose of medication or frequency of use but to inform health care provider. Caution patient that larger doses or more frequent dosing does not increase effectiveness and may cause excessive drowsiness or other side effects.
- Instruct patient to stop taking drug and immediately report any of these symptoms to health care provider: persistent dizziness; excessive drowsiness; severe dry mouth, nose, or throat; flushing; unexplained shortness of breath or difficulty breathing; unusual tiredness or weakness; sore throat, fever, or other signs of infection; bleeding or unusual bruising; fast or irregular heartbeat; excitability, confusion, or changes in thinking or behavior; chest tightness; difficulty urinating.
- Advise patient that medication may cause drowsiness or dizziness and not to drive or perform other activities requiring mental alertness until tolerance is determined.
- Advise patient to take sips of water, suck on ice chips or sugarless hard candy, or chew sugarless gum if dry mouth occurs.
- Caution patient that alcohol and other CNS depressants (eg, sedatives) will have additional sedative effects if taken with carbinoxamine.
- Caution patient not to take any OTC antihistamines while taking this medication unless advised by health care provider.
- Caution patient that medication may cause sensitivity to sunlight and to avoid excessive exposure to the sun or UV light (eg, tanning booths) and to wear protective clothing and use sunscreens until tolerance is determined.
- If patient is to have allergy skin testing, advise patient not to take the medication for at least 4 days before the skin testing.
Copyright © 2009 Wolters Kluwer Health.
- Carbinoxamine Prescribing Information (FDA)
- carbinoxamine Concise Consumer Information (Cerner Multum)
- Histex CT Extended-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)
- Histex Pd Liquid MedFacts Consumer Leaflet (Wolters Kluwer)
- Histex Pd 12 MedFacts Consumer Leaflet (Wolters Kluwer)
- Palgic MedFacts Consumer Leaflet (Wolters Kluwer)