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Drugs reference index «Activella»

Activella


Activella

Generic name: Estradiol/norethindrone acetateBrand names: Prefest, Activella and femhrt, Activella

Why is Activella prescribed?

Activella is prescribed for hormone replacement therapy. It contains estrogen and progestin hormones. Activella is used after menopause to reduce hot flashes and help prevent thinning bones (osteoporosis). It is also used to treat postmenopausal vaginal symptoms such as dryness, itching, and burning.

Most important fact about Activella

Using estrogen, with or without progestin, may increase your risk for heart attack, stroke, dementia, breast cancer, and blood clots. If you or a family member has a history of these conditions, talk to your doctor about whether Activella is right for you.

How should you take Activella?

Take one tablet at the same time each day, with or without food. Estrogen should be used at the lowest dose possible and only when treatment is clearly needed. You should talk regularly with your doctor (usually every 3 to 6 months) about the dose you are taking and whether you still need treatment with Activella.

  • If you miss a dose...Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take two doses at the same time.
  • Storage instructions...Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this product.

  • Side effects may include:Abdominal/stomach cramps and bloating, back pain, breast pain, depression, hair loss, headache, irregular vaginal bleeding or spotting, nausea and vomiting, weight gain

Less common but serious side effects of estrogen therapy may include breast cancer, uterine cancer, stroke, heart attack, blood clots, dementia, gallbladder disease, and ovarian cancer. See your doctor immediately if you developing any of the warning signs listed below.

  • Warning signs of serious side effects may include:Breast lumps, changes in speech or vision, chest pain, dizziness, fainting, pains in your legs, severe headaches, shortness of breath, unusual vaginal bleeding, vomiting

Why should Activella not be prescribed?

Do not take Activella if you have:

A history of any cancer stimulated by estrogen, such as breast or uterine cancerHad a stroke or heart attack in the past yearUnexplained or unusual vaginal bleedingA history of blood clotsA history of liver problemsSensitivity to estrogen, progestin, or any other ingredient in ActivellaAny reason to believe that you are pregnant

If you've had your uterus removed, you don't need the progestin in this product, and should take a different type of hormone replacement therapy.

Special warnings about Activella

Tell your doctor about your complete medical history, especially if you have any of the following: problems with your heart, liver, thyroid, or kidneys; asthma; epilepsy or a history of seizures; migraine headaches; endometriosis; lupus; high cholesterol; high blood pressure; diabetes; a history of smoking; or high levels of calcium in your blood. Also tell your doctor if you are going to have surgery or be on bed rest; you may need to stop taking estrogen.

In addition to increasing the chances of uterine cancer, estrogen replacement therapy may also raise the odds of breast cancer if taken at high doses or for long periods of time. Be sure to get regular breast exams and mammograms, and see your gynecologist for yearly checkups.

Estrogen replacement therapy typically doubles the chances of gallbladder disease. Notify your doctor if you experience pain, tenderness, or swelling in your abdomen.

Estrogen replacement increases the risk of blood clots in the veins, especially during the first year of therapy. Call your doctor immediately if you experience any of the following warning signs: bulging eyes, changes in vision or speech, coughing up blood, dizziness, double vision, faintness, migraine headaches, pains in the calves or chest, severe headache or vomiting, sudden shortness of breath, sudden vision loss, weakness or numbness of an arm or leg.

Estrogen therapy sometimes causes high blood pressure, so be sure to get periodic checkups. In women prone to high blood lipid levels, estrogen can also cause a sharp spike in triglycerides, possibly leading to pancreatitis. Fluid retention is another possibility. If it develops, it can aggravate conditions such as asthma, epilepsy, heart disease, kidney disease, and migraine headaches.

Make sure your doctor knows if you have ever been diagnosed with depression. Treatment with estrogen therapy should be discontinued if depression recurs.

If you have diabetes, watch your blood sugar levels especially carefully. There's a chance that estrogen/progestin products may make diabetes worse.

Possible food and drug interactions when taking Activella

Tell the doctor about all prescription, over-the-counter, and herbal medications you are taking. The manufacturer does not list specific drug interactions for Activella. However, it's possible that if estrogen is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining estrogen with the following:

AcetaminophenAntibiotics such as clarithromycin and erythromycinAntifungal drugs such as itraconazole and ketoconazoleAnti-HIV drugs such as ritonavirAspirinClofibrateCyclosporineGrapefruit juiceMorphineSeizure medications such as carbamazepine, and phenobarbitalSteroid medications such as prednisoneRifampinSt. John's wortTemazepamTheophylline

Special information if you are pregnant or breastfeeding

Although Activella is intended only for women who are no longer in their childbearing years, it's important to note that Activella should never be taken during pregnancy, since it can harm the developing baby. Additionally, do not use Activella if you are breastfeeding; the hormones in Activella can pass into breast milk.

Recommended dosage for Activella

ADULTS

The recommended dose is one tablet daily.

Overdosage

Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

  • Symptoms of overdose may include:Nausea, vomiting, vaginal bleeding
  • Activella Prescribing Information (FDA)
  • Activella MedFacts Consumer Leaflet (Wolters Kluwer)
  • Activella Concise Consumer Information (Cerner Multum)
  • Activella Advanced Consumer (Micromedex) - Includes Dosage Information
  • CombiPatch Patch (Bi-weekly) MedFacts Consumer Leaflet (Wolters Kluwer)
  • CombiPatch Prescribing Information (FDA)
  • Combipatch topical patches Concise Consumer Information (Cerner Multum)

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