Generic Name: chlordiazepoxide (klor dye az e POX ide)Brand names: Librium, Mitran
Chlordiazepoxide is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Chlordiazepoxide affects chemicals in the brain that may become unbalanced and cause anxiety.
Chlordiazepoxide is used to treat anxiety disorders or alcohol withdrawal.
Chlordiazepoxide may also be used for other purposes not listed in this medication guide.
Before taking chlordiazepoxide, tell your doctor if you have any breathing problems, glaucoma, porphyria, kidney or liver disease, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol.Do not drink alcohol while taking chlordiazepoxide. This medication can increase the effects of alcohol.
Tell your doctor if you regularly use other medicines that make you sleepy. They can add to sleepiness caused by chlordiazepoxide.Chlordiazepoxide may be habit-forming and should be used only by the person it was prescribed for. Chlordiazepoxide should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.What should I discuss with my healthcare provider before taking chlordiazepoxide?Do not use this medication if you are allergic to chlordiazepoxide or to other benzodiazepines, such as alprazolam (Xanax), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).
Before taking chlordiazepoxide, tell your doctor if you are allergic to any drugs, or if you have:
asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;
kidney or liver disease;
a history of depression or suicidal thoughts or behavior; or
a history of drug or alcohol addiction.
If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication.Chlordiazepoxide may be habit-forming and should be used only by the person it was prescribed for. Chlordiazepoxide should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Chlordiazepoxide can cause birth defects in an unborn baby. Do not use chlordiazepoxide without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Chlordiazepoxide may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. The sedative effects of chlordiazepoxide may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking chlordiazepoxide.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results from this medication.Chlordiazepoxide should be used for only a short time. Do not take this medication for longer than 4 months without your doctor's advice. Contact your doctor if this medicine seems to stop working as well in treating your symptoms. Do not stop using chlordiazepoxide suddenly, or you could have seizures or unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when you stop using chlordiazepoxide.
To be sure this medication is not causing harmful effects, your blood and liver function may need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.Store chlordiazepoxide at room temperature away from moisture, heat, and light.
Keep track of how many pills have been used from each new bottle of this medicine. Benzodiazepines are drugs of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.
See also: Chlordiazepoxide dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include extreme drowsiness, confusion, excitation, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, or coma.
Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, or depression can add to sleepiness caused by chlordiazepoxide. Tell your doctor if you regularly use any of these medicines, or any other anxiety medications.
depressed mood, thoughts of suicide or hurting yourself;
restless muscle movements in your eyes, tongue, jaw, or neck;
hyperactivity, agitation, hostility;
jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
nausea, vomiting, constipation; or
irregular menstrual periods.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Anxiety:
Moderate anxiety: 5 to 10 mg orally 3 to 4 times a day.Severe anxiety: 20 to 25 mg orally 3 to 4 times a day or 50 to 100 mg IM or IV followed by 25 to 50 mg 3 to 4 times a day if necessary.
Usual Adult Dose for Light Sedation:
For light sedation prior to a medical or surgical procedure.Oral: 5 mg 3 times a day may be started several days before the procedure.IM: 50 mg one hour before the procedure
Usual Adult Dose for Alcohol Withdrawal:
IM or IV: 50 to 100 mg initially. May repeat in 2 to 4 hours if necessary.Oral: 50 to 100 mg followed by repeated doses as needed until agitation is controlled (up to 300 mg/day). Dosage should then be reduced to maintenance levels.
Before taking chlordiazepoxide, tell your doctor if you are using any of the following drugs:
a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Solfoton);
a blood thinner such as warfarin (Coumadin); or
an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate);
medicine to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril);
narcotic medication such as butorphanol (Stadol), codeine, hydrocodone (Lortab, Vicodin), levorphanol (Levo-Dromoran), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Kadian, MS Contin, Oramorph), naloxone (Narcan), oxycodone (OxyContin), propoxyphene (Darvon, Darvocet); or
an antidepressant such as amitriptyline (Elavil, Etrafon), amoxapine (Asendin), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), protriptyline (Vivactil), sertraline (Zoloft), or trimipramine (Surmontil).
This is not a complete list and there may be other drugs that can interact with chlordiazepoxide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.