Brand names: Diuril
Diuril is used in the treatment of high blood pressure and other conditions that require the elimination of excess fluid (water) from the body. These conditions include congestive heart failure, cirrhosis of the liver, corticosteroid and estrogen therapy, and kidney disease. When used for high blood pressure, Diuril can be used alone or with other high blood pressure medications. Diuril contains a form of thiazide, a diuretic that prompts your body to eliminate more fluid, which helps lower blood pressure.
If you have high blood pressure, you must take Diuril regularly for it to be effective. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Diuril; and you must continue taking it even if you are feeling well. Diuril does not cure high blood pressure; it merely keeps it under control.
Take Diuril exactly as prescribed. Stopping Diuril suddenly could cause your condition to worsen.
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Diuril.
If you are unable to urinate, you should not take Chlorothiazide. If you are sensitive to or have ever had an allergic reaction to Diuril or other thiazide-type diuretics, or if you are sensitive to sulfa drugs, you should not take Chlorothiazide.
Diuretics can cause your body to lose too much potassium. Signs of an excessively low potassium level include muscle weakness and rapid or irregular heartbeat. To boost your potassium level, your doctor may recommend eating potassium-rich foods or taking a potassium supplement.
If you are taking Diuril, your doctor will do a complete assessment of your kidney function and continue to monitor it. Use with caution if you have severe kidney disease.
If you have liver disease, diabetes, gout, or the connective tissue disease lupus erythematosus, your doctor will prescribe Diuril cautiously.
If you have bronchial asthma or a history of allergies you may be at greater risk for an allergic reaction to Chlorothiazide.
Dehydration, excessive sweating, severe diarrhea, or vomiting could deplete your body's fluids and lower your blood pressure too much. Be careful when exercising and in hot weather.
Notify your doctor or dentist that you are taking Diuril if you have a medical emergency, and before you have surgery or dental treatment.
Diuril may increase the effects of alcohol. Do not drink alcohol while taking Chlorothiazide.
If Diuril is taken with certain other drugs, the effects of either may be increased, decreased, or altered. It is especially important to check with your doctor before combining Diuril with the following:Barbiturates such as phenobarbital and secobarbitalCholesterol-lowering drugs such as cholestyramine and colestipolDrugs to treat diabetes such as insulin and glyburideLithiumNarcotic painkillers such as oxycodoneNonsteroidal anti-inflammatory drugs such as ibuprofen and naproxenNorepinephrineOther drugs for high blood pressure such as captopril and nifedipineSteroids such as prednisone
The effects of Diuril during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Diuril appears in breast milk and could affect a nursing infant. If Chlorothiazide is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment is finished.
Diuril comes in tablets, an oral suspension, and an intravenous preparation, reserved for emergencies. Dosages below are for the oral preparations.
Swelling due to excess water
The usual dose is 0.5 gram to 1 gram 1 or 2 times per day. Your doctor may have you take Chlorothiazide on alternate days or on some other on-off schedule.
High Blood Pressure
The starting dose is 0.5 gram to 1 gram per day, taken as one dose or two or more smaller doses. Your doctor will adjust the dosage to suit your needs.
Dosages for children are adjusted according to weight, generally 10 milligrams per pound of body weight daily in 2 doses.
Under 6 months
Dosage may be up to 15 milligrams per pound of body weight per day in 2 doses.
Under 2 years
The usual dosage is 125 milligrams to 375 milligrams per day in 2 doses. The liquid form of Chlorothiazide may be used in children under 2 years of age at a dosage of 1/2 to 1-1/2 teaspoons (2.5 to 7.5 milliliters) per day.
2 to 12 years
The usual dosage is 375 milligrams to 1 gram daily in 2 doses. The liquid form of Chlorothiazide may be used in children 2 to 12 years at a dosage of 1-1/2 to 4 teaspoons (7.5 milliliters to 20 milliliters) per day.
Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.