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Drugs reference index «Chlorpromazine»



Generic Name: Chlorpromazine (klor-PRO-mah-zeen)Brand Name: Thorazine

Chlorpromazine is used for:

Treating certain types of emotional, behavioral, or mental conditions. In addition, it may be used to control nausea, vomiting, or continuous hiccups, treat the blood disease porphyria, or to help to treat tetanus. It may also be used for other conditions as determined by your doctor.

Chlorpromazine is a phenothiazine. The exact way Chlorpromazine works is not known.

Do NOT use Chlorpromazine if:

  • you are allergic to any ingredient in Chlorpromazine
  • you have severe CNS depression (drowsiness leading to unconsciousness or coma)
  • you are also taking cisapride, dofetilide, an H1 antagonist (eg, astemizole, terfenadine), 1A and 1C antiarrhythmics (eg, quinidine, flecainide), metrizamide, pimozide, a quinolone (eg, sparfloxacin), or ziprasidone

Contact your doctor or health care provider right away if any of these apply to you.

Before using Chlorpromazine :

Some medical conditions may interact with Chlorpromazine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of heart, lung, liver, or kidney problems; or a history of breast cancer
  • if you have seizures, blood disease, low blood pressure, glaucoma, an enlarged prostate, or difficulty urinating
  • if you have Parkinson disease, Reye syndrome, or alcoholism, or drink more than 3 alcohol-containing drinks per day

Some MEDICINES MAY INTERACT with Chlorpromazine . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticholinergics (eg, benztropine) because they may decrease Chlorpromazine 's effectiveness
  • Metrizamide because side effects, such as increased risk of seizures, may occur
  • Arsenic, beta-adrenergic blockers (eg, propranolol), cisapride, dofetilide, droperidol, H1 antagonists (eg, astemizole), haloperidol, IA and IC antiarrhythmics (eg, quinidine, flecainide), macrolide antibiotics (eg, azithromycin), ketolides (eg, telithromycin), meperidine, pimozide, quinolones (eg, sparfloxacin), streptogramins (eg, quinupristin), tricyclic antidepressants (eg, amitriptyline), or ziprasidone because side effects, such as rapid or irregular heartbeat, low blood pressure, difficult or slow breathing, or drowsiness leading to coma, may occur
  • Guanethidine, levodopa, pergolide, or warfarin because their effectiveness may be decreased by Chlorpromazine
  • Beta-blockers (eg, propranolol), epinephrine, or hydantoins (eg, phenytoin), because their actions and the risk of their side effects may be increased by Chlorpromazine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Chlorpromazine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Chlorpromazine :

Use Chlorpromazine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Chlorpromazine is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Chlorpromazine at home, a health care provider will teach you how to use it. Be sure you understand how to use Chlorpromazine . Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Chlorpromazine if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Chlorpromazine may irritate skin. Avoid contact with skin or clothing. Wear rubber gloves while using Chlorpromazine .
  • Do not suddenly stop taking Chlorpromazine .
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Chlorpromazine , use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Chlorpromazine .

Important safety information:

  • Chlorpromazine may cause drowsiness, dizziness, blurred vision, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Chlorpromazine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Chlorpromazine ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Tell your doctor or dentist that you take Chlorpromazine before you receive any medical or dental care, emergency care, or surgery.
  • Do not become overheated in hot weather or while you are being active; heatstroke may occur.
  • Chlorpromazine may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Chlorpromazine . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Some patients who take Chlorpromazine may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Chlorpromazine in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Chlorpromazine .
  • Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Chlorpromazine . Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
  • Use Chlorpromazine with caution in the ELDERLY; they may be more sensitive to its effects, especially low blood pressure and nerve-muscle reactions.
  • Chlorpromazine should not be used in CHILDREN younger than 6 months old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Chlorpromazine while you are pregnant. Chlorpromazine is found in breast milk. Do not breast-feed while using Chlorpromazine .

Possible side effects of Chlorpromazine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; constipation; dizziness; drowsiness; dry mouth; light sensitivity; nasal congestion.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue); changes in breasts; changes in menstrual period; changes in vision; chest pain; chills; confusion; difficulty swallowing; difficulty urinating; drooling; extreme tiredness; fever; inability to move eyes; involuntary movements of the face, mouth, tongue, or jaw; jitteriness; lip smacking or puckering; mask-like face; muscle spasms of the face, neck, or back; prolonged or painful erection; puffing of cheeks; rigid muscles; seizures; shuffling walk; skin discoloration; sleeplessness; sore throat; stiff arms or legs; tremors of hands; twitching or twisting movements; weakness of arms or legs; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; muscle spasms; restlessness; seizures; tremors; twitching.

Proper storage of Chlorpromazine :

Store Chlorpromazine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Chlorpromazine out of the reach of children and away from pets.

General information:

  • If you have any questions about Chlorpromazine , please talk with your doctor, pharmacist, or other health care provider.
  • Chlorpromazine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Chlorpromazine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Chlorpromazine Prescribing Information (FDA)
  • Chlorpromazine Detailed Consumer Information (PDR)
  • chlorpromazine Concise Consumer Information (Cerner Multum)

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