Trade Names:Loprox- Cream 0.77%- Suspension, topical 0.77%- Gel 0.77%- Shampoo 1%
Trade Names:Penlac Nail Lacquer- Solution, topical 8%Stieprox (Canada)
Broad-spectrum, antifungal agent with an unknown mechanism of action.
Absorption is 1.3% with topical application followed by occlusion for 6 h.
The primary route of metabolism is glucuronidation. The t ½ is 1.7 h with excretion primarily via the kidney.
Topical treatment of seborrheic dermatitis of the scalp in adults.Gel
Interdigital tinea pedis and tinea corporis caused by T. rubrum , T. mentagrophytes , or E. floccosum .Cream/Suspension
Tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm) caused by T. rubrum , T. mentagrophytes , E. floccosum , and M. canis ; cutaneous candidiasis (moniliasis) caused by C. albicans ; tinea (pityriasis) versicolor caused by M. furfur .Penlac
As a component of a comprehensive management program for topical treatment in immunocompetent patients with mild to moderate onychomycosis of fingernails and toenails without lunula involvement, caused by T. rubrum .
Topical Wet hair and apply approximately 1 tsp (5 mL) to the scalp. Up to 2 tsp (10 mL) may be used for long hair. Lather and leave on hair and scalp for 3 min. Rinse off. Repeat treatment 2 times/wk for 4 wk, with a minimum of 3 days between applications. If no improvement after 4 wk of treatment, reevaluate the diagnosis.Loprox cream/suspensionAdults and children 10 yr of age and older
Topical Gently massage cream into the affected and surrounding skin areas twice daily, morning and evening. If no improvement after 4 wk of treatment, reevaluate the diagnosis.Loprox gelAdults and children 16 yr of age and older
Topical Gently massage gel into affected skin areas of scalp areas twice daily, morning and evening. If no improvement after 4 wk of treatment, reevaluate the diagnosis.PenlacAdults
Topical Apply every day, at bedtime or 8 h before washing, to all affected nails with the provided applicator. Apply evenly over the entire nail plate. If possible, apply to nail bed, hyponychium, and the under surface of the nail plate when it is free of the nail bed (eg, onycholysis). Do not remove product on a daily basis. Make daily applications over the previous coat and remove with alcohol every 7 days, repeating this cycle throughout the duration of therapy. As a comprehensive management program for onychomycosis, removal of the unattached, infected nail, as frequently as monthly, by a health care professional, weekly trimming by the patient, and daily application of the medication are integral parts of therapy.
Store cream, gel, solution, suspension, and shampoo at room temperature (59° to 86°F). Discard any unused shampoo 8 wk after opening. Protect solution from light and away from heat and flame. Keep solution tightly capped and stored in original carton after each use.
None well documented.
None well documented.
Ventricular tachycardia ( Loprox shampoo).
Pruritus at application site, worsening of clinical signs and symptoms, burning ( Loprox cream); skin burning sensation upon application (34% of patients with seborrheic dermatitis; 7% with tinea pedis); periungual erythema and erythema of the proximal nail fold (5%); contact dermatitis, pruritus (1% to 5%); dry skin, acne, rash, alopecia, pain upon application, eye pain, facial edema (less than 1%; Loprox gel); pruritus, burning ( Loprox suspension); increased itching, application site reactions (eg, burning, erythema, itching), nail disorders (eg, shape change, irritation), application site reactions and/or burning of the skin (1%); seborrhea, rash, headache, skin disorder ( Loprox shampoo); mild rash ( Penlac topical solution).
MonitorApplication site reactions
Monitor for application site reactions, including redness, itching, burning, blistering, swelling, or oozing. Inform health care provider if noted and significant.Skin/Nail assessment
Assess the skin or nails, as appropriate, and identify areas where medication is to be applied. Assess and document skin or nail condition before initial application and periodically throughout treatment.
Category B .
Safety and efficacy not established in children younger than 16 yr of age.Loprox cream/suspension
Safety and efficacy not established in children younger than 10 yr of age.Penlac
Safety and efficacy not established.
For external use only, avoid contact with the eyes.
If sensitivity or chemical irritation occurs, discontinue treatment and institute appropriate therapy.
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