Generic Name: cinacalcet (sin ah CAL set)Brand Names: Sensipar
Cinacalcet decreases levels of parathyroid hormone (PTH), calcium, and phosphorous in the body.
Cinacalcet is used to treat hypoparathyroidism (decreased functioning of the parathyroid glands) in people who are on long-term dialysis for kidney disease.
Cinacalcet is also used to lower calcium levels in people with cancer of the parathyroid gland.
Cinacalcet may also be used for other purposes not listed in this medication guide.
Before you take cinacalcet, tell your doctor if you have high blood pressure, heart disease, heart failure, a heart rhythm disorder, liver disease, or a history of seizures.There are many other medicines that can interact with cinacalcet. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list of all the medicines you use and show this list to any doctor or other healthcare provider who treats you. Cinacalcet works best if you take it with food or shortly after eating a meal. Do not crush or break a cinacalcet tablet. Swallow the pill whole.
Your blood will need to be tested on a regular basis while you are taking cinacalcet. Do not miss any follow-up visits to your doctor.Call your doctor at once if you have a serious side effect such as numbness or tingly feeling around your mouth, fast or slow heart rate, muscle tightness or contraction, overactive reflexes, seizure, feeling short of breath, swelling, rapid weight gain, or feeling like you might pass out.
If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:
high blood pressure;
heart disease, heart failure, heart rhythm disorder;
a history or seizures; or
Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results from this medication.Cinacalcet works best if you take it with food or shortly after eating a meal. Do not crush or break a cinacalcet tablet. Swallow the pill whole.
To be sure your calcium and phosphorous levels do not get too low, your blood will need to be tested 1 week after you start taking cinacalcet or whenever your dose is changed. You may also need blood tests on a regular basis during treatment. Do not miss any follow-up visits to your doctor.Store cinacalcet at room temperature away from moisture, light, and heat.
See also: Cinacalcet dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
Symptoms of a cinacalcet overdose are not known.
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
numbness or tingly feeling around your mouth, fast or slow heart rate, muscle tightness or contraction, overactive reflexes;
feeling short of breath, even with mild exertion;
swelling, rapid weight gain; or
feeling like you might pass out.
Less serious side effects may include:
nausea, vomiting, diarrhea;
loss of appetite;
muscle pain, mild chest pain;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Secondary Hyperparathyroidism:
Secondary Hyperparathyroidism in patients with chronic kidney disease on dialysis:Starting dose: 30 mg orally once a day.
Usual Adult Dose for Hypercalcemia of Malignancy:
Hypercalcemia in patients with parathyroid carcinoma:Starting dose: 30 mg orally twice daily.
Many drugs can interact with cinacalcet. Below is just a partial list. Tell your doctor if you are using:
diclofenac (Arthrotec, Cataflam, Voltaren, Flector Patch, Solareze);
isoniazid (for treating tuberculosis);
bladder medication such as tamsulosin (Flomax) or tolterodine (Detrol);
an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek);
an antidepressant such as amitriptyline (Elavil, Vanatrip), desipramine (Norpramin), duloxetine (Cymbalta), fluoxetine (Prozac), nefazodone, nortriptyline (Pamelor), paroxetine (Paxil), sertraline (Zoloft), and others
antifungal medication such as itraconazole (Sporanox) or ketoconazole (Nizoral);
ADHD medication such as atomoxetine (Strattera), dextroamphetamine (Adderall), or methylphenidate (Ritalin, Daytrana, Metadate, Concerta);
cancer medicine such as doxorubicin (Adriamycin, Doxil), lomustine (CeeNU), tamoxifen (Soltamox);
cough medicine (narcotic or over-the-counter;
heart or blood pressure medication such as carvedilol (Coreg), diltiazem (Cartia, Cardizem), felodipine (Plendil), flecainide (Tambocor), labetalol (Normodyne), metoprolol (Lopressor), nifedipine (Nifedical, Procardia), procainamide (Procan, Pronestyl), propafenone (Rythmol), propranolol (Inderal), verapamil (Calan, Covera, Isoptin, Verelan), and others;
HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir);
medicine to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), promethazine (Phenergan), or thioridazine (Mellaril); or
pain medication such as codeine (Tylenol #3),, hydrocodone (Lortab, Vicodin, Vicoprofen), oxycodone (OxyContin, Percocet), or tramadol (Ultram, Ultracet).