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Drugs reference index «cinacalcet»

cinacalcet

Generic Name: cinacalcet (sin ah CAL set)Brand Names: Sensipar

What is cinacalcet?

Cinacalcet decreases levels of parathyroid hormone (PTH), calcium, and phosphorous in the body.

Cinacalcet is used to treat hypoparathyroidism (decreased functioning of the parathyroid glands) in people who are on long-term dialysis for kidney disease.

Cinacalcet is also used to lower calcium levels in people with cancer of the parathyroid gland.

Cinacalcet may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about cinacalcet?

You should not take this medication if you are allergic to cinacalcet.

Before you take cinacalcet, tell your doctor if you have high blood pressure, heart disease, heart failure, a heart rhythm disorder, liver disease, or a history of seizures.

There are many other medicines that can interact with cinacalcet. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list of all the medicines you use and show this list to any doctor or other healthcare provider who treats you. Cinacalcet works best if you take it with food or shortly after eating a meal. Do not crush or break a cinacalcet tablet. Swallow the pill whole.

Your blood will need to be tested on a regular basis while you are taking cinacalcet. Do not miss any follow-up visits to your doctor.

Call your doctor at once if you have a serious side effect such as numbness or tingly feeling around your mouth, fast or slow heart rate, muscle tightness or contraction, overactive reflexes, seizure, feeling short of breath, swelling, rapid weight gain, or feeling like you might pass out.

What should I discuss with my healthcare provider before taking cinacalcet?

You should not take this medication if you are allergic to cinacalcet.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

  • high blood pressure;

  • heart disease, heart failure, heart rhythm disorder;

  • a history or seizures; or

  • liver disease.
FDA pregnancy category C. It is not known whether cinacalcet is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether cinacalcet passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give this medication to a child without a doctor's advice.

How should I take cinacalcet?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Cinacalcet works best if you take it with food or shortly after eating a meal. Do not crush or break a cinacalcet tablet. Swallow the pill whole.

To be sure your calcium and phosphorous levels do not get too low, your blood will need to be tested 1 week after you start taking cinacalcet or whenever your dose is changed. You may also need blood tests on a regular basis during treatment. Do not miss any follow-up visits to your doctor.

Store cinacalcet at room temperature away from moisture, light, and heat.

See also: Cinacalcet dosage in more detail

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a cinacalcet overdose are not known.

What should I avoid while taking cinacalcet?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Cinacalcet side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
  • numbness or tingly feeling around your mouth, fast or slow heart rate, muscle tightness or contraction, overactive reflexes;

  • seizure (convulsions);

  • feeling short of breath, even with mild exertion;

  • swelling, rapid weight gain; or

  • feeling like you might pass out.

Less serious side effects may include:

  • nausea, vomiting, diarrhea;

  • loss of appetite;

  • muscle pain, mild chest pain;

  • dizziness; or

  • weakness;

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Cinacalcet Dosing Information

Usual Adult Dose for Secondary Hyperparathyroidism:

Secondary Hyperparathyroidism in patients with chronic kidney disease on dialysis:Starting dose: 30 mg orally once a day.

Usual Adult Dose for Hypercalcemia of Malignancy:

Hypercalcemia in patients with parathyroid carcinoma:Starting dose: 30 mg orally twice daily.

What other drugs will affect cinacalcet?

Many drugs can interact with cinacalcet. Below is just a partial list. Tell your doctor if you are using:

  • chloroquine (Arelan);

  • conivaptan (Vaprisol);

  • diclofenac (Arthrotec, Cataflam, Voltaren, Flector Patch, Solareze);

  • imatinib (Gleevec);

  • isoniazid (for treating tuberculosis);

  • bladder medication such as tamsulosin (Flomax) or tolterodine (Detrol);

  • an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek);

  • an antidepressant such as amitriptyline (Elavil, Vanatrip), desipramine (Norpramin), duloxetine (Cymbalta), fluoxetine (Prozac), nefazodone, nortriptyline (Pamelor), paroxetine (Paxil), sertraline (Zoloft), and others

  • antifungal medication such as itraconazole (Sporanox) or ketoconazole (Nizoral);

  • ADHD medication such as atomoxetine (Strattera), dextroamphetamine (Adderall), or methylphenidate (Ritalin, Daytrana, Metadate, Concerta);

  • cancer medicine such as doxorubicin (Adriamycin, Doxil), lomustine (CeeNU), tamoxifen (Soltamox);

  • cough medicine (narcotic or over-the-counter;

  • heart or blood pressure medication such as carvedilol (Coreg), diltiazem (Cartia, Cardizem), felodipine (Plendil), flecainide (Tambocor), labetalol (Normodyne), metoprolol (Lopressor), nifedipine (Nifedical, Procardia), procainamide (Procan, Pronestyl), propafenone (Rythmol), propranolol (Inderal), verapamil (Calan, Covera, Isoptin, Verelan), and others;

  • HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir);

  • medicine to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), promethazine (Phenergan), or thioridazine (Mellaril); or

  • pain medication such as codeine (Tylenol #3),, hydrocodone (Lortab, Vicodin, Vicoprofen), oxycodone (OxyContin, Percocet), or tramadol (Ultram, Ultracet).

There are many other medicines that can interact with cinacalcet. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Where can I get more information?

  • Your pharmacist can provide more information about cinacalcet.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 3.01. Revision Date: 12/22/2009 3:20:30 PM.
  • cinacalcet Advanced Consumer (Micromedex) - Includes Dosage Information
  • Cinacalcet MedFacts Consumer Leaflet (Wolters Kluwer)
  • Sensipar Prescribing Information (FDA)
  • Sensipar Consumer Overview

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